Evidence map›Paper›PMID 27599755›Full record

ReviewWiley interdisciplinary reviews. Systems biology and medicine2016

Data sources for in vivo molecular profiling of human phenotypes.

Timothy Cardozo, Priyanka Gupta, Eric Ni, Lauren M Young, Doreen Tivon, Klara Felsovalyi

Abstract readReview
In one paragraph

Review in Wiley interdisciplinary reviews. Systems biology and medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Druggability of Targets for Diagnostic Radiopharmaceuticals.ACS pharmacology & translational science · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Timothy CardozoDepartment of Biochemistry and Molecular Pharmacology, NYU School of Medicine, New York, NY, USA. Timothy.Cardozo@nyumc.org.
Priyanka GuptaDepartment of Biochemistry and Molecular Pharmacology, NYU School of Medicine, New York, NY, USA.
Eric NiDepartment of Biochemistry and Molecular Pharmacology, NYU School of Medicine, New York, NY, USA.
Lauren M YoungDepartment of Pathology, NYU School of Medicine, New York, NY, USA.
Doreen TivonGeneCentrix Inc., New York, NY, USA.
Klara FelsovalyiGeneCentrix Inc., New York, NY, USA.

Funding

Novel tool for linking drugs to phenotypes - I-Corps SupplementR43GM113546 · NIGMS · GENECENTRIX, INC. · PI FELSOVALYI, KLARA O · 2015 to 2016
$808k
BD2K product for enhancing phenotypic screensR43LM012577 · NLM · GENECENTRIX, INC. · PI YOUNG, LAUREN MEREDITH · 2017 to 2017
$150k
NIGMS NIH HHS R43 GM113546NLM NIH HHS R43 LM012577
6 · The paper itself

Abstract

Molecular profiling of human diseases has been approached at the genetic (DNA), expression (RNA), and proteomic (protein) levels. An important goal of these efforts is to map observed molecular patterns to specific, mechanistic organic entities, such as loci in the genome, individual RNA molecules or defined proteins or protein assemblies. Importantly, such maps have been historically approached in the more intuitive context of a theoretical individual cell, but diseases are better described in reality using an in vivo framework, namely a library of several tissue-specific maps. In this article, we review the existing data atlases that can be used for this purpose and identify critical gaps that could move the field forward from cellular to in vivo dimensions. WIREs Syst Biol Med 2016, 8:472-484. doi: 10.1002/wsbm.1354 For further resources related to this article, please visit the WIREs website.

Indexed as

Databases, FactualBrainDNAGenomicsGlucose Transporter Type 1HumansPhenotypeProteinsProteomicsDNAGlucose Transporter Type 1Proteins

Identifiers

PMID27599755
PMCPMC6560639

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.