ArticleScientific reports2016
Coherence-Gated Sensorless Adaptive Optics Multiphoton Retinal Imaging.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 28 citations in OpenAlex.
- Image formation theory of optical coherence tomography with optical aberrations and its application to computational aberration correction.Biomedical optics express · 2025Article
- From mouse to human: Accessing the biochemistry of vision in vivo by two-photon excitation.Progress in retinal and eye research · 2023Review
- Two-photon excitation fluorescence in ophthalmology: safety and improved imaging for functional diagnostics.Frontiers in medicine · 2023Review
- Label-free metabolic and structural profiling of dynamic biological samples using multimodal optical microscopy with sensorless adaptive optics.Scientific reports · 2022Article
- Closed-loop wavefront sensing and correction in the mouse brain with computed optical coherence microscopy.Biomedical optics express · 2021Article
- Adaptive optics for high-resolution imaging.Nature reviews. Methods primers · 2021Article
- Computed optical coherence microscopy of mouse brain ex vivo.Journal of biomedical optics · 2019Article
- Non-invasive cellular-resolution retinal imaging with two-photon excited fluorescence.Biomedical optics express · 2019Article
- Adaptive optics in the mouse eye: wavefront sensing based vs. image-guided aberration correction.Biomedical optics express · 2019Article
- Automated sensorless single-shot closed-loop adaptive optics microscopy with feedback from computational adaptive optics.Optics express · 2019Article
- Sensorless adaptive optics multimodal en-face small animal retinal imaging.Biomedical optics express · 2019Article
- Noninvasive Two-Photon Microscopy Imaging of Mouse Retina and Retinal Pigment Epithelium.Methods in molecular biology (Clifton, N.J.) · 2019Article
- Two-photon imaging of the mammalian retina with ultrafast pulsing laser.JCI insight · 2018Article
- Volumetric fluorescence retinal imagingBiomedical optics express · 2018Article
- Computational optical coherence tomography [Invited].Biomedical optics express · 2017Article
- Vision science and adaptive optics, the state of the field.Vision research · 2017Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
Abstract
Multiphoton microscopy enables imaging deep into scattering tissues. The efficient generation of non-linear optical effects is related to both the pulse duration (typically on the order of femtoseconds) and the size of the focused spot. Aberrations introduced by refractive index inhomogeneity in the sample distort the wavefront and enlarge the focal spot, which reduces the multiphoton signal. Traditional approaches to adaptive optics wavefront correction are not effective in thick or multi-layered scattering media. In this report, we present sensorless adaptive optics (SAO) using low-coherence interferometric detection of the excitation light for depth-resolved aberration correction of two-photon excited fluorescence (TPEF) in biological tissue. We demonstrate coherence-gated SAO TPEF using a transmissive multi-actuator adaptive lens for in vivo imaging in a mouse retina. This configuration has significant potential for reducing the laser power required for adaptive optics multiphoton imaging, and for facilitating integration with existing systems.
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