Evidence map›Paper›PMID 27599536›Full record

ReviewNeurodegenerative disease management2016

Alzheimer's disease: the potential therapeutic role of the natural antibiotic amyloid-β peptide.

Deepak Kumar Vijaya Kumar, William A Eimer, Rudolph E Tanzi, Robert D Moir

Abstract readReview
In one paragraph

Review in Neurodegenerative disease management, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Herpes simplex virus infection and Alzheimer's disease.Frontiers in aging neuroscience · 2026
    Review
  5. Article
  6. From defense to disease: IFITM3 in immunity and Alzheimer's disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. Review
  12. Review
  13. Article
  14. γ-Secretase in Alzheimer's disease.Experimental & molecular medicine · 2022
    Review
  15. Perspectives on theToxins · 2021
    Review
  16. Article
  17. Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Deepak Kumar Vijaya KumarGenetics & Aging Research Unit, Department of Neurology, Massachusetts General Hospital & Harvard Medical School, Charlestown, MA 02129, USA.
William A EimerGenetics & Aging Research Unit, Department of Neurology, Massachusetts General Hospital & Harvard Medical School, Charlestown, MA 02129, USA.
Rudolph E TanziGenetics & Aging Research Unit, Department of Neurology, Massachusetts General Hospital & Harvard Medical School, Charlestown, MA 02129, USA.
Robert D MoirGenetics & Aging Research Unit, Department of Neurology, Massachusetts General Hospital & Harvard Medical School, Charlestown, MA 02129, USA.

Funding

The Abeta protein of Alzheimer's Disease is an antimicrobial peptideR01AI081990 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI MOIR, ROBERT D · 2010 to 2014
$2.2M
NIAID NIH HHS R01 AI081990
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Anti-Infective AgentsImmunity, InnateAlzheimer DiseaseAmyloid beta-PeptidesAnimalsHumansAmyloid beta-PeptidesAnti-Infective AgentsAlzheimer's diseaseamyloid-βinfection

Identifiers

PMID27599536
PMCPMC5558531

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.