Evidence map›Paper›PMID 27599513›Full record

ArticleDoklady. Biochemistry and biophysics2016

The gene therapy of collagen-induced arthritis in rats by intramuscular administration of the plasmid encoding TNF-binding domain of variola virus CrmB protein.

S N Shchelkunov, O S Taranov, T V Tregubchak, R A Maksyutov, A N Silkov, A E Nesterov, S V Sennikov

Abstract read
PubMed Publisher
In one paragraph

Article in Doklady. Biochemistry and biophysics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. TNF Decoy Receptors Encoded by Poxviruses.Pathogens (Basel, Switzerland) · 2021
    Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

S N ShchelkunovVector State Research Center of Virology and Biotechnology, Koltsovo, Novosibirsk oblast, 633159, Russia. snshchel@vector.nsc.ru.
O S TaranovVector State Research Center of Virology and Biotechnology, Koltsovo, Novosibirsk oblast, 633159, Russia.
T V TregubchakVector State Research Center of Virology and Biotechnology, Koltsovo, Novosibirsk oblast, 633159, Russia.
R A MaksyutovVector State Research Center of Virology and Biotechnology, Koltsovo, Novosibirsk oblast, 633159, Russia.
A N SilkovResearch Institute of Clinical Immunology, Siberian Branch, Russian Academy of Medical Sciences, ul. Yadrintsevskaya 14, Novosivirsk, 630099, Russia.
A E NesterovVector State Research Center of Virology and Biotechnology, Koltsovo, Novosibirsk oblast, 633159, Russia.
S V SennikovResearch Institute of Clinical Immunology, Siberian Branch, Russian Academy of Medical Sciences, ul. Yadrintsevskaya 14, Novosivirsk, 630099, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Wistar rats with collagen-induced arthritis were intramuscularly injected with the recombinant plasmid pcDNA/sTNF-BD encoding the sequence of the TNF-binding protein domain of variola virus CrmB protein (VARV sTNF-BD) or the pcDNA3.1 vector. Quantitative analysis showed that the histopathological changes in the hind-limb joints of rats were most severe in the animals injected with pcDNA3.1 and much less severe in the group of rats injected with pcDNA/sTNF-BD, which indicates that gene therapy of rheumatoid arthritis is promising in the case of local administration of plasmids governing the synthesis of VARV immunomodulatory proteins.

Indexed as

AnimalsArthritis, ExperimentalArthritis, RheumatoidCarrier ProteinsFemaleGenetic TherapyGenetic VectorsHindlimbInjections, IntramuscularMaleRats, WistarSynovitisTreatment OutcomeVariola virusViral ProteinsCarrier ProteinsViral Proteins

Identifiers

PMID27599513

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.