ArticleEmerging microbes & infections2016
Culex pipiens quinquefasciatus: a potential vector to transmit Zika virus.
Article in Emerging microbes & infections, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers, 3 of them syntheses that pooled it.
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Who cites it
90 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Secondary vectors of Zika Virus, a systematic review of laboratory vector competence studies.PLoS neglected tropical diseases · 2023Pooled it
- Pooled it
- Zika virus: An updated review of competent or naturally infected mosquitoes.PLoS neglected tropical diseases · 2017Pooled it
- Control and mitigation of dengue and Zika virus transmission in a hospital in Recife, Brazil: a successful experience with an integrated control program against Aedes aegypti.Parasites & vectors · 2026Article
- Transcriptome Analysis ofTropical medicine and infectious disease · 2025Article
- Dissecting Zika virus transmission byFrontiers in microbiology · 2025Article
- Interepidemic xenosurveillance of Japanese encephalitis virus and Zika virus inVeterinary world · 2024Article
- Coexistence of adult mosquitoes (Diptera: Culicidae) inside dwellings in a rural community during a dengue outbreak in Sullana, Piura, 2023.Revista peruana de medicina experimental y salud publica · 2024Article
- Integrated Strategies forTropical medicine and infectious disease · 2024Article
- Exposure to Zika and chikungunya viruses impacts aspects of the vectorial capacity of Aedes aegypti and Culex quinquefasciatus.PloS one · 2024Article
- Occurrence of arbovirus infections in two riverine populations in the municipality of Humaitá, Amazonas, Brazil.Revista da Sociedade Brasileira de Medicina Tropical · 2024Article
- Article
- Advances in viral encephalitis: Viral transmission, host immunity, and experimental animal models.Zoological research · 2023Review
- Article
- Assessment of the Risk of Exotic Zika Virus Strain Transmission byTropical medicine and infectious disease · 2023Article
- Genomic and phenotypic analyses suggest moderate fitness differences among Zika virus lineages.PLoS neglected tropical diseases · 2023Article
- Zika vector competence data reveals risks of outbreaks: the contribution of the European ZIKAlliance project.Nature communications · 2022Article
- Diversity and functional profile of gut symbiotic bacteria betweenFrontiers in microbiology · 2022Article
- Entomovirological Surveillance in Schools: Are They a Source for Arboviral Diseases Transmission?International journal of environmental research and public health · 2021Article
- Development and validation of a one-step reverse transcription loop-mediated isothermal amplification (RT-LAMP) for rapid detection of ZIKV in patient samples from Brazil.Scientific reports · 2021Article
30 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Zika virus (ZIKV) has become a threat to global health since the outbreak in Brazil in 2015. Although ZIKV is generally considered an Aedes-transmitted pathogen, new evidence has shown that parts of the virus closely resemble Culex-transmitted viruses. Therefore, it is important to evaluate the competence of Culex species for ZIKV to understand their potential as vectors. In this study, female Culex pipiens quinquefasciatus were orally exposed to ZIKV. Mosquito midguts, salivary glands and ovaries were tested for ZIKV to measure infection and dissemination at 2, 4, 6, 8, 12, 16 and 18 days post exposure (pe). In addition, saliva was collected from mosquitoes after infection and infant mice were bitten by infected mosquitoes to measure the transmission ability of Cx. p. quinquefasciatus. The results showed that the peak time of virus appearance in the salivary glands was day 8 pe, with 90% infection rate and an estimated virus titer of 3.92±0.49 lg RNA copies/mL. Eight of the nine infant mice had positive brains after being bitten by infected mosquitoes, which meant that Cx. p. quinquefasciatus could be infected with and transmit ZIKV following oral infection. These laboratory results clearly demonstrate the potential role of Cx. p. quinquefasciatus as a vector of ZIKV in China. Because there are quite different vector management strategies required to control Aedes (Stegomyia) species and Cx. p. quinquefasciatus, an integrated approach may be required should a Zika epidemic occur.
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