Trial reportBritish journal of cancer2016
Detection of micrometastases by flow cytometry in sentinel lymph nodes from patients with renal tumours.
Trial report in British journal of cancer, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 24 citations in OpenAlex.
- Clear cell renal cell carcinoma micrometastasis: Insights from an unconventional cutaneous presentation.Skin health and disease · 2024Article
- Raludotatug Deruxtecan, a CDH6-Targeting Antibody-Drug Conjugate with a DNA Topoisomerase I Inhibitor DXd, Is Efficacious in Human Ovarian and Kidney Cancer Models.Molecular cancer therapeutics · 2024Article
- Precisional detection of lymph node metastasis using tFCM in colorectal cancer.Open life sciences · 2023Article
- Potential benefit of lymph node dissection during radical nephrectomy for kidney cancer: A review and critical analysis of current literature.Asian journal of urology · 2022Review
- Inflammatory lymphadenopathy in renal cell carcinoma: prognostic tool?Annals of translational medicine · 2019Article
- The contemporary role of lymph node dissection in the management of renal cell carcinoma.Therapeutic advances in urology · 2018Review
- Detection of micro-metastases by flow cytometry in lymph nodes from patients with penile cancer.BMC urology · 2018Article
- Rapid nodal staging of head and neck cancer surgical specimens with flow cytometric analysis.British journal of cancer · 2018Article
- Metas-Chip precisely identifies presence of micrometastasis in live biopsy samples by label free approach.Nature communications · 2017Article
- Kidney cancer: Micrometastases detectable using flow cytometry.Nature reviews. Urology · 2016Article
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundStage is an important prognostic factor in renal tumours and dissemination to regional lymph nodes is associated with poor outcomes. Lymph nodes are routinely assessed by immunohistochemistry and microscopic evaluation, a time-consuming process where micrometastases might go undiagnosed. We evaluate an alternative method for detecting metastatic cells in sentinel nodes (SNs) by flow cytometry.
methodsA total of 15 nodes from 5 patients diagnosed with renal tumours were analysed by flow cytometry. Staining for the intracellular marker cytokeratin 18 (CK18) with the surface markers carbonic anhydrase IX (CA9) and Cadherin 6 were used in flow cytometry analysis. Peripheral blood mononuclear cells (PBMCs) with the addition of known concentrations of cancer cell lines were analysed to investigate the sensitivity of micrometastasis detection.
resultsStability of the assay was marked by low intra-assay variability (coefficient of variance ⩽16%) and low inter-assay variability (R
conclusionsFlow cytometry is able to detect micrometastases in lymph nodes of renal tumour patients that were undetected under H&E examination.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.