Evidence map›Paper›PMID 27598348›Full record

ReviewSouthern medical journal2016

Management of Sickle Cell Disease in Children.

Suzie A Noronha, S Christy Sadreameli, John J Strouse

Open access · greenAbstract readReview
In one paragraph

Review in Southern medical journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Suzie A NoronhaFrom the Department of Pediatrics, University of Rochester, Rochester, New York, the Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, and the Division of Hematology, Duke University School of Medicine, Durham, North Carolina.
S Christy SadreameliFrom the Department of Pediatrics, University of Rochester, Rochester, New York, the Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, and the Division of Hematology, Duke University School of Medicine, Durham, North Carolina.
John J StrouseFrom the Department of Pediatrics, University of Rochester, Rochester, New York, the Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, and the Division of Hematology, Duke University School of Medicine, Durham, North Carolina.
Johns Hopkins University · US

Funding

Institute for Clinical and Translational ResearchKL2TR001077 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$9.2M
Hydroxyurea to Prevent CNS Complications of Sickle Cell Disease in ChildrenR34HL108756 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI CASELLA, JAMES F, DEBAUN, MICHAEL R. · 2011 to 2014
$1.1M
NCATS NIH HHS KL2 TR001077NHLBI NIH HHS R34 HL108756
6 · The paper itself

Abstract

Sickle cell disease (SCD) is a heterogeneous inherited disorder of hemoglobin that causes chronic hemolytic anemia, vaso-occlusion, and endothelial dysfunction. These physiologic derangements often lead to multiorgan damage in infancy and throughout childhood. The most common types of SCD are homozygous hemoglobin S (HbSS disease), hemoglobin SC disease, and sickle β thalassemia. HbSS disease and sickle β(0) thalassemia often are referred to as sickle cell anemia because they have similar severity. Screening and preventive measures, including infection prophylaxis and vaccination, have significantly improved outcomes for children with SCD. Evidence-based therapies, such as hydroxyurea and transfusion, play an important role in preventing progression of select complications. Many chronic complications develop insidiously and require multidisciplinary care for effective treatment. Primary care physicians, as well as physicians in many other disciplines, may care for these patients and should be familiar with the potential acute and chronic complications of this disease. This review addresses healthcare maintenance guidelines, common complications, and recommendations for management of pediatric patients with SCD.

Indexed as

Anemia, Sickle CellAntisickling AgentsChildGastrointestinal DiseasesHeart DiseasesHumansHydroxyureaLung DiseasesNervous System DiseasesAntisickling AgentsHydroxyurea

Identifiers

PMID27598348
PMCPMC12858083
OpenAlexW2520767525

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.