ArticleThe Journal of organic chemistry2016
Artificial Macrocycles by Ugi Reaction and Passerini Ring Closure.
Article in The Journal of organic chemistry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 44 citations in OpenAlex.
- Access to Cyclic Monensin Derivatives via a Four-Component Ugi Reaction.The Journal of organic chemistry · 2026Article
- Multicomponent Macrocyclic IL-17a Modifier.ACS medicinal chemistry letters · 2022Article
- LIMO: Latent Inceptionism for Targeted Molecule Generation.Proceedings of machine learning research · 2022Article
- Catalyst-Free One-Pot Synthesis of Densely Substituted Pyrazole-Pyrazines as Anti-Colorectal Cancer Agents.Scientific reports · 2020Article
- Tetrazoles via Multicomponent Reactions.Chemical reviews · 2019Review
- Synthesis of (macro)heterocycles by consecutive/repetitive isocyanide-based multicomponent reactions.Beilstein journal of organic chemistry · 2019Review
- Design of indole- and MCR-based macrocycles as p53-MDM2 antagonists.Beilstein journal of organic chemistry · 2019Article
- Artificial Macrocycles.Synlett : accounts and rapid communications in synthetic organic chemistry · 2018Article
- Functionalized Spiroindolines with Anticancer Activity through a Metal-Free Post-Ugi Diastereoselective One-Pot Cascade Reaction.Chemistry (Weinheim an der Bergstrasse, Germany) · 2018Article
- Synthesis of Highly Substituted Imidazole Uracil Containing Molecules via Ugi-4CR and Passerini-3CR.ACS combinatorial science · 2018Article
- Concise Synthesis of Macrocycles by Multicomponent Reactions.Synthesis · 2018Article
- Synthetic fermentation of β-peptide macrocycles by thiadiazole-forming ring-closing reactions.Chemical science · 2018Article
- Ugi Multicomponent Reaction Based Synthesis of Medium-Sized Rings.Organic letters · 2017Article
- Concise Synthesis of Tetrazole Macrocycle.Organic letters · 2017Article
- Two-Step Synthesis of Complex Artificial Macrocyclic Compounds.Angewandte Chemie (International ed. in English) · 2017Article
- With unprotected amino acids to tetrazolo peptidomimetics.Chemical communications (Cambridge, England) · 2017Article
- Highly Stereoselective Synthesis of a Compound Collection Based on the Bicyclic Scaffolds of Natural Products.Molecules (Basel, Switzerland) · 2017Article
- Artificial Macrocycles by Ugi Reaction and Passerini Ring Closure.The Journal of organic chemistry · 2016Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
Abstract
Artificial macrocycles can be convergently synthesized by a sequence of an Ugi multicomponent reaction (MCR) followed by an intramolecular Passerini MCR used to close the macrocycle. Significantly, in this work, the first intramolecular macrocyclization through a Passerini reaction is described. We describe 21 macrocycles of a size of 15-20. The resulting macrocyclic depsipeptides are model compounds for natural products and could find applications in drug discovery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.