ArticleNature biotechnology2016
Expression of an insecticidal fern protein in cotton protects against whitefly.
Article in Nature biotechnology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 132 citations in OpenAlex.
- Basic Research on Whitefly Molecular Biology: A Foundation for Innovative Pest Management Strategies.Current issues in molecular biology · 2026Review
- Article
- Requirement of group I lytic polysaccharide monooxygenase for turnover of chitinous cuticle during moulting in two forest pest beetles, Monochamus alternatus and Psacothea hilaris.Insect molecular biology · 2026Article
- Mechanisms, detection, and impact of horizontal gene transfer in plant functional evolution.The Plant cell · 2025Review
- Comparative transcriptomics in ferns reveals key innovations and divergent evolution of the secondary cell walls.Nature plants · 2025Article
- The Marchantia polymorpha pangenome reveals ancient mechanisms of plant adaptation to the environment.Nature genetics · 2025Article
- Spatiotemporal regulation of anther's tapetum degeneration paved the way for a reversible male sterility system in cotton.Plant biotechnology journal · 2025Article
- Transgenic tomato strategies targeting whitefly eggs from apoplastic or ovary-directed proteins.BMC plant biology · 2024Article
- Enhancing cotton whitefly (Bemisia tabaci) detection and counting with a cost-effective deep learning approach on the Raspberry Pi.Plant methods · 2024Article
- Research Progress on Viruses ofBiology · 2024Review
- Attraction of Sweet Potato Whitefly,Insects · 2024Article
- Review
- Bridging fungal resistance and plant growth through constitutive overexpression of Thchit42 gene in Pelargonium graveolens.Plant cell reports · 2024Article
- Widespread horizontal gene transfer between plants and bacteria.ISME communications · 2024Article
- Cross-kingdom convergence provides promising proteins for pest control.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Novel insecticidal proteins from ferns resemble insecticidal proteins fromProceedings of the National Academy of Sciences of the United States of America · 2023Article
- An Insight into Emerging Begomoviruses and their Satellite Complex causing Papaya Leaf Curl Disease.Current genomics · 2023Review
- Article
- Species composition and population dynamics of some arthropod pests in cotton fields of irrigated and semi-arid regions of Punjab, Pakistan.Saudi journal of biological sciences · 2023Article
- Plant resistance against whitefly and its engineering.Frontiers in plant science · 2023Review
Corrections and comments
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Authors and funding
28 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Whitefly (Bemisia tabaci) damages field crops by sucking sap and transmitting viral diseases. None of the insecticidal proteins used in genetically modified (GM) crop plants to date are effective against whitefly. We report the identification of a protein (Tma12) from an edible fern, Tectaria macrodonta (Fee) C. Chr., that is insecticidal to whitefly (median lethal concentration = 1.49 μg/ml in in vitro feeding assays) and interferes with its life cycle at sublethal doses. Transgenic cotton lines that express Tma12 at ∼0.01% of total soluble leaf protein were resistant to whitefly infestation in contained field trials, with no detectable yield penalty. The transgenic cotton lines were also protected from whitefly-borne cotton leaf curl viral disease. Rats fed Tma12 showed no detectable histological or biochemical changes, and this, together with the predicted absence of allergenic domains in Tma12, indicates that Tma12 might be well suited for deployment in GM crops to control whitefly and the viruses it carries.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.