SynthesisPloS one2016
Acute, Recent and Past HEV Infection among Voluntary Blood Donors in China: A Systematic Review and Meta-Analysis.
Synthesis in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Prevalence of hepatitis E virus in China from 1997 to 2022: a systematic review and meta-analysis.Frontiers in public health · 2023Pooled it
- Hepatitis E virus infection among pregnant women in Africa: systematic review and meta-analysis.BMC infectious diseases · 2019Pooled it
- Prevalence of hepatitis G virus infection among 67,348 blood donors in mainland China.BMC public health · 2019Pooled it
- Seroprevalence of hepatitis E virus infection in pregnant women: a systematic review and meta-analysis.Annals of Saudi medicinePooled it
- Clinical Guidelines for Hepatitis E Vaccination in India: An Expert Panel Consensus Report on the Recombinant Hepatitis E Vaccine, HEV 239.Pathogens (Basel, Switzerland) · 2026Review
- Elevated risk of hepatitis E virus infection among sheep smallholders in Xinjiang, China.One health (Amsterdam, Netherlands) · 2026Article
- Viral hepatitis E: Clinical manifestations, treatment, and prevention.Liver research (Beijing, China) · 2024Review
- Development and clinical validation of a one-step pentaplex real-time reverse transcription PCR assay for detection of hepatitis virus B, C, E, Treponema pallidum, and a human housekeeping gene.BMC infectious diseases · 2023Article
- [Consensus on prevention and treatment of hepatitis E].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2022Article
- Transfusion-transmitted hepatitis E: What we know so far?World journal of gastroenterology · 2022Review
- Hepatitis E virus infection in the United States: Seroprevalence, risk factors and the influence of immunological assays.PloS one · 2022Article
- Review
- Hepatitis E virus prevalence among blood donors in Dali, China.Virology journal · 2021Article
- HEV prevalence and potential risk factors in a large multi-ethnic youth cohort in China.Virology journal · 2021Article
- Hepatitis E virus and blood transfusion safety.Epidemiology and infection · 2020Review
- Seroprevalence of viral hepatitis A, B, C, D and E viruses in the Hormozgan province southern Iran.BMC infectious diseases · 2019Article
- High seroprevalence of hepatitis E virus in the ethnic minority populations in Yunnan, China.PloS one · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionHepatitis E virus is one of new threats to blood safety which was usually considered to be transmitted via fecal-oral route. China is one of the hyperendemic regions where frequent outbreaks of hepatitis E are noted. However, the overall prevalence of HEV infection among mainland Chinese blood donors is not clear until now.
methodThe peer-reviewed literatures reporting the prevalence of HEV in Chinese blood donors were identified by systematic searching of five electronic databases. The systematic review and meta-analysis were conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement issued in 2009. Data manipulation and statistical analyses were performed by Stata 12.0.
resultsFourteen eligible articles involving 22 independent studies were included. Pooled prevalence of HEV infection biomarkers (anti-HEV IgG, anti-HEV IgM, RNA and antigen) among mainland Chinese blood donors were 29.2%, 1.1%, 0.1% and 0.1%, respectively which were higher than the data reported in other countries. The analysis of HEV genotypes indicated that the most prevalent strains in Chinese blood donors were genotype 1 and 4.
conclusionsMainland China is indicated with a relatively higher risk of transmission of hepatitis E through transfusion and the screening of blood donors for HEV RNA, especially in HEV-endemic areas, might reduce the potential risk of HEV infection via transfusion.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.