ArticleJournal of diabetes research2016
Comparison of the Current Diagnostic Criterion of HbA1c with Fasting and 2-Hour Plasma Glucose Concentration.
Article in Journal of diabetes research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 4 of them syntheses that pooled it.
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Who cites it
28 citing papers in PubMed, 4 syntheses or guidelines pooled it, 54 citations in OpenAlex.
- Comparison of diagnostic accuracy for diabetes diagnosis: A systematic review and network meta-analysis.Frontiers in medicine · 2023Pooled it
- American Association of Clinical Endocrinology Clinical Practice Guideline: Developing a Diabetes Mellitus Comprehensive Care Plan-2022 Update.Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 2022Guideline
- Treatment of periodontitis for glycaemic control in people with diabetes mellitus.The Cochrane database of systematic reviews · 2022Pooled it
- Diagnostic accuracy of tests for type 2 diabetes and prediabetes: A systematic review and meta-analysis.PloS one · 2020Pooled it
- Diabetes Prevalence and Associated Factors Among Pasifika Adults in Australia: Findings from the Pasifika Preventing Diabetes Programme.Medical sciences (Basel, Switzerland) · 2026Article
- Association of Family Meals and Prediabetes Among South Korean Adults Without Diabetes.Journal of diabetes research · 2026Article
- The prevalence of secondhand smoke exposure and its association with chronic diseases and metabolic abnormalities: findings from the STEPS survey 2021.Journal of diabetes and metabolic disorders · 2025Article
- Socioeconomic and sex disparities in hypertension and diabetes mellitus care cascade among tribal populations in Odisha, India: findings from the Odisha Tribal Family Health Survey (OTFHS), 2022-23.BMC public health · 2025Article
- Impact of Metformin Therapy on Vitamin B12 Levels in Patients With Type 2 Diabetes Mellitus.Endocrinology, diabetes & metabolism · 2025Article
- Astaxanthin Modulates Inflammation in Type 2 Diabetes via Regulation of microRNAs, Lysophosphatidylcholine, and α-Hydroxybutyrate.International journal of endocrinology · 2025Article
- Reproducibility of Glycemic Measures Among Dysglycemic Youth and Adults in the RISE Study.The Journal of clinical endocrinology and metabolism · 2023Article
- Different Trajectories for Diabetes Mellitus Onset and Recovery According to the Centralized Aerobic-Anaerobic Energy Balance Compensation Theory.Biomedicines · 2023Article
- Discrepancy in diagnoses of diabetes and prediabetes using fasting plasma glucose and glycosylated hemoglobin and the underdiagnosis by ICD-10 coding: data from a tertiary hospital in Thailand.Frontiers in public health · 2023Article
- Review
- The sonographic quantitative assessment of the deltoid muscle to detect type 2 diabetes mellitus: a potential noninvasive and sensitive screening method?BMC endocrine disorders · 2022Article
- Optimizing diabetes screening frequencies for at-risk groups.Health care management science · 2022Article
- Recent Developments in Biomarkers for Diagnosis and Screening of Type 2 Diabetes Mellitus.Current diabetes reports · 2022Review
- Current Challenges and Future Trends of Enzymatic Paper-Based Point-of-Care Testing for Diabetes Mellitus Type 2.Biosensors · 2021Review
- The Role of Hemoglobin A1C in Diabetes Screening and Diabetic Retinopathy.Journal of clinical medicine · 2021Article
- Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To determine the effectiveness of hemoglobin A1c (HbA1c) ≥ 6.5% in diagnosing diabetes compared to fasting plasma glucose (FPG) ≥ 126 mg/dL and 2-hour plasma glucose (2hPG) ≥ 200 mg/dL in a previously undiagnosed diabetic cohort, we included 5,764 adult subjects without established diabetes for whom HbA1c, FPG, 2hPG, and BMI measurements were collected. Compared to the FPG criterion, the sensitivity of HbA1c ≥ 6.5% was only 43.3% (106 subjects). Compared to the 2hPG criterion, the sensitivity of HbA1c ≥ 6.5% was only 28.1% (110 subjects). Patients who were diabetic using 2hPG criterion but had HbA1c < 6.5% were more likely to be older (64 ± 15 versus 60 ± 15 years old, P = 0.01, mean ± STD), female (53.2% versus 38.2%, P = 0.008), leaner (29.7 ± 6.1 versus 33.0 ± 6.6 kg/m(2), P = 0.000005), and less likely to be current smokers (18.1% versus 29.1%, P = 0.02) as compared to those with HbA1c ≥ 6.5%. The diagnostic agreement in the clinical setting revealed the current HbA1c ≥ 6.5% is less likely to detect diabetes than those defined by FPG and 2hPG. HbA1c ≥ 6.5% detects less than 50% of diabetic patients defined by FPG and less than 30% of diabetic patients defined by 2hPG. When the diagnosis of diabetes is in doubt by HbA1c, FPG and/or 2hPG should be obtained.
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