Evidence map›Paper›PMID 27597971›Full record

ArticleBioMed research international2016

Interaction Effects between Organochlorine Pesticides and Isoflavones In Vitro and In Vivo.

Yunbo Zhang, Jipeng Guo, Xiao Zhang, Jingjing Guo, Ming Zhang, Yang Yang, Xiaolin Na

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 89% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Yunbo ZhangDepartment of Environmental Hygiene, Public Health College, Harbin Medical University, Harbin, Heilongjiang 150081, China.ORCID 0000-0001-6792-1451
Jipeng GuoDepartment of Environmental Hygiene, Public Health College, Harbin Medical University, Harbin, Heilongjiang 150081, China.ORCID 0000-0001-6445-6427
Xiao ZhangDepartment of Environmental Hygiene, Public Health College, Harbin Medical University, Harbin, Heilongjiang 150081, China.ORCID 0000-0002-2492-6938
Jingjing GuoDepartment of Environmental Hygiene, Public Health College, Harbin Medical University, Harbin, Heilongjiang 150081, China.ORCID 0000-0002-3688-7825
Ming ZhangDepartment of Environmental Hygiene, Public Health College, Harbin Medical University, Harbin, Heilongjiang 150081, China.ORCID 0000-0002-5941-9485
Yang YangDepartment of Environmental Hygiene, Public Health College, Harbin Medical University, Harbin, Heilongjiang 150081, China.ORCID 0000-0002-1946-816X
Xiaolin NaDepartment of Environmental Hygiene, Public Health College, Harbin Medical University, Harbin, Heilongjiang 150081, China.ORCID 0000-0003-3891-7490
Harbin Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Organochlorine pesticides (OCPs) have caused increasing global concern due to their high toxicity, persistence, bioaccumulation, and significant adverse effects on human health. This study was to explore the interaction effects between OCPs and isoflavones. Six kinds of OCPs and 2 kinds of isoflavones-genistein and daidzein were included to study their effect on MCF-7 cells in vitro. Eighty-one female Sprague-Dawley rats were randomized to 9 groups according to factorial design to study the interaction effect between isoflavones and γ-HCH. Compared to organochlorine pesticides alone group, proliferation rate of MCF-7 cells was lower in 100 μmol/L genistein + organochlorine pesticides and 100 μmol/L daidzein + organochlorine pesticides group (p < 0.05). In vivo study showed that there are interaction effects on kidney weight and liver weight when treated with isoflavones and γ-HCH. The changes in uterine morphology and positive expression of ERα showed inhibition effects between isoflavones and γ-HCH. In conclusion, the data suggests that there are interactions between isoflavones and OCPs in vitro and in vivo.

Indexed as

Biological AssayChromatography, GasEnvironmental PollutantsFemaleHumansHydrocarbons, ChlorinatedIsoflavonesMaleMiddle AgedPesticidesReproducibility of ResultsSensitivity and SpecificitySweatEnvironmental PollutantsHydrocarbons, ChlorinatedIsoflavonesPesticides

Identifiers

PMID27597971
PMCPMC5002470
OpenAlexW2514919568

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.