SynthesisCanadian journal of gastroenterology & hepatology2016
Colorectal Cancer Screening in Average Risk Populations: Evidence Summary.
Synthesis in Canadian journal of gastroenterology & hepatology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 6 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- Deaths and cardiopulmonary events following colorectal cancer screening-A systematic review with meta-analyses.PloS one · 2024Pooled it
- Pooled it
- Pooled it
- Colorectal cancer screening for patients with a family history of colorectal cancer or adenomas.Canadian family physician Medecin de famille canadien · 2019Pooled it
- Colorectal cancer screening with faecal testing, sigmoidoscopy or colonoscopy: a systematic review and network meta-analysis.BMJ open · 2019Pooled it
- Colorectal Cancer Screening in Average Risk Populations: Evidence Summary.Canadian journal of gastroenterology & hepatology · 2016Pooled it
- Using Facebook to Improve Participation in Colorectal Cancer Screening: Protocol for a Cluster Randomized Controlled Trial.JMIR research protocols · 2026Article
- Risk of metachronous advanced neoplasia was comparable between patients with 1-2 and 3-4 non-advanced adenomas removed during screening colonoscopy.Surgical endoscopy · 2026Article
- Article
- Differential Outcomes in Colorectal Cancer Detection: A Comparative Study of Swedish Nationwide Screening and Fast-Track Diagnostic Pathways.Journal of clinical gastroenterology · 2025Article
- Physical harms in colorectal cancer screening: An overview of the reporting in systematic reviews and randomised controlled trials.PloS one · 2025Review
- Review
- Developing a Health Equity Impact Assessment 'Indigenous Lens Tool' to address challenges in providing equitable cancer screening for indigenous peoples.BMC public health · 2023Article
- Implementation of an organized colorectal cancer screening program through quantitative fecal immunochemical test followed by colonoscopy in an urban low-income community: Guidance and strategies.Clinics (Sao Paulo, Brazil) · 2023Article
- Provincial variation in colorectal cancer screening adherence in Canada; evidence from the Canadian Partnership for Tomorrow's Health.Frontiers in oncology · 2023Article
- Screening for Colorectal Cancer.Hematology/oncology clinics of North America · 2022Review
- Using Facebook to promote the uptake of colorectal cancer screening.BMC public health · 2022Article
- Risk-stratified strategies in population screening for colorectal cancer.International journal of cancer · 2022Review
- A Real-Time Endoscope Motion Tracker.IEEE journal of translational engineering in health and medicine · 2022Article
- The colon cancer screening behaviours survey for South Asians: a pilot study of feasibility and psychometric evaluation.Journal of patient-reported outcomes · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 7 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction. The objectives of this systematic review were to evaluate the evidence for different CRC screening tests and to determine the most appropriate ages of initiation and cessation for CRC screening and the most appropriate screening intervals for selected CRC screening tests in people at average risk for CRC. Methods. Electronic databases were searched for studies that addressed the research objectives. Meta-analyses were conducted with clinically homogenous trials. A working group reviewed the evidence to develop conclusions. Results. Thirty RCTs and 29 observational studies were included. Flexible sigmoidoscopy (FS) prevented CRC and led to the largest reduction in CRC mortality with a smaller but significant reduction in CRC mortality with the use of guaiac fecal occult blood tests (gFOBTs). There was insufficient or low quality evidence to support the use of other screening tests, including colonoscopy, as well as changing the ages of initiation and cessation for CRC screening with gFOBTs in Ontario. Either annual or biennial screening using gFOBT reduces CRC-related mortality. Conclusion. The evidentiary base supports the use of FS or FOBT (either annual or biennial) to screen patients at average risk for CRC. This work will guide the development of the provincial CRC screening program.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.