Evidence map›Paper›PMID 27597820›Full record

ReviewFrontiers in human neuroscience2016

Attachment, Neurobiology, and Mentalizing along the Psychosis Continuum.

Martin Debbané, George Salaminios, Patrick Luyten, Deborah Badoud, Marco Armando, Alessandra Solida Tozzi, Peter Fonagy, Benjamin K Brent

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in human neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed, 4 pooled it
65.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 4 syntheses or guidelines pooled it, 150 citations in OpenAlex.

  1. Pooled it
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  3. Migration and schizophrenia: meta-analysis and explanatory framework.European archives of psychiatry and clinical neuroscience · 2020
    Pooled it
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  7. Article
  8. Psychiatric diagnosis on the edge: is there evidence of benefit?European child & adolescent psychiatry · 2026
    Article
  9. The Network Model of Mentalization, Social Vulnerability, and the Self in Autism: A Comparison With Neurotypical Adults.Autism research : official journal of the International Society for Autism Research · 2026
    Article
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2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 4 countries.

Martin DebbanéFaculty of Psychology and Educational Sciences, University of GenevaGeneva, Switzerland; Research Department of Clinical, Educational and Health Psychology, University College LondonLondon, UK; Office Médico-PédagogiqueGeneva, Switzerland.
George SalaminiosResearch Department of Clinical, Educational and Health Psychology, University College London London, UK.
Patrick LuytenResearch Department of Clinical, Educational and Health Psychology, University College LondonLondon, UK; Faculty of Psychology and Educational Sciences, University of LeuvenLeuven, Belgium.
Deborah BadoudFaculty of Psychology and Educational Sciences, University of Geneva Geneva, Switzerland.
Marco ArmandoOffice Médico-Pédagogique Geneva, Switzerland.
Alessandra Solida TozziDepartment of Psychiatry, Lausanne University Hospital (CHUV) Lausanne, Switzerland.
Peter FonagyResearch Department of Clinical, Educational and Health Psychology, University College London London, UK.
Benjamin K BrentDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical School Boston, MA, USA.
University College London · GBUniversity of Geneva · CHMassachusetts General Hospital · USOffice Médico Pédagogique · CHUniversity of Lausanne · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this review article, we outline the evidence linking attachment adversity to psychosis, from the premorbid stages of the disorder to its clinical forms. To better understand the neurobiological mechanisms through which insecure attachment may contribute to psychosis, we identify at least five neurobiological pathways linking attachment to risk for developing psychosis. Besides its well documented influence on the hypothalamic-pituary-adrenal (HPA) axis, insecure attachment may also contribute to neurodevelopmental risk through the dopaminergic and oxytonergic systems, as well as bear influence on neuroinflammation and oxidative stress responses. We further consider the neuroscientific and behavioral studies that underpin mentalization as a suite of processes potentially moderating the risk to transition to psychotic disorders. In particular, mentalization may help the individual compensate for endophenotypical impairments in the integration of sensory and metacognitive information. We propose a model where embodied mentalization would lie at the core of a protective, resilience response mitigating the adverse and potentially pathological influence of the neurodevelopmental cascade of risk for psychosis.

Indexed as

HPAmentalizingschizophreniaschizotypyselftheory of mindUHR

Identifiers

PMID27597820
PMCPMC4992687
OpenAlexW2507500167

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.