Evidence map›Paper›PMID 27597757›Full record

ArticleThe Journal of cell biology2016

Beyond the SNARE: Munc18-1 chaperones α-synuclein.

Mugdha Deshpande, Avital A Rodal

Open access · hybridAbstract readComment
In one paragraph

Article in The Journal of cell biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 92% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Mugdha DeshpandeDepartment of Biology, Brandeis University, Waltham, MA 02453.
Avital A RodalDepartment of Biology, Brandeis University, Waltham, MA 02453 arodal@brandeis.edu.
Brandeis University · US

Funding

Activity-dependent regulation of membrane traffic and growth signaling in neuronsDP2NS082127 · NINDS · BRANDEIS UNIVERSITY · PI RODAL, AVITAL ADAH · 2012 to 2012
$2.4M
Structure and regulation of synaptic architectureR00NS060947 · NINDS · BRANDEIS UNIVERSITY · PI RODAL, AVITAL ADAH · 2010 to 2012
$775k
Structure and regulation of synaptic architectureK99NS060947 · NINDS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI RODAL, AVITAL ADAH · 2008 to 2009
$180k
NINDS NIH HHS DP2 NS082127NINDS NIH HHS K99 NS060947NINDS NIH HHS R00 NS060947
6 · The paper itself

Abstract

Early infantile epileptic encephalopathy (EIEE)-associated mutations in MUNC18-1 cause Munc18-1 misfolding and cellular aggregation. In this issue, Chai et al. (2016. J. Cell Biol http://dx.doi.org/10.1083/jcb.201512016) find that Munc18-1 is a molecular chaperone for α-synuclein and that aggregated Munc18-1 EIEE-causing mutants promote α-synuclein aggregation.

Indexed as

alpha-SynucleinHumansMolecular ChaperonesMutationProtein BindingSNARE Proteinsalpha-SynucleinMolecular ChaperonesSNARE Proteins

Identifiers

PMID27597757
PMCPMC5021099
OpenAlexW2513836925

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.