Observational studyLung cancer (Amsterdam, Netherlands)2016
Depression symptom trends and health domains among lung cancer patients in the CanCORS study.
Observational study in Lung cancer (Amsterdam, Netherlands), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Global research and emerging trends in depression in lung cancer: a bibliometric and visualized study from 2014 to 2024.Frontiers in oncology · 2025Pooled it
- Effectiveness of message framing on pulmonary rehabilitation behavior for lung cancer surgery patients: Randomized controlled trial.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Trial
- Pilot randomized controlled trial of a comprehensive smoking cessation intervention for patients with upper aerodigestive cancer undergoing radiotherapy.Head & neck · 2018Trial
- Prognostic significance of dynamic emotional distress during neoadjuvant therapy and surgery for resectable non-small cell lung cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- Disparities in Depression Among Older Asian, Native Hawaiian, and Pacific Islander Patients With Lung Cancer.Cancer medicine · 2026Article
- Changes in Depressive Patterns Before and After Lung Cancer Diagnosis: A Nationwide Population-Based Study.Psycho-oncology · 2025Article
- Prevalence and Correlates of Distress Detected by the Distress Thermometer and Problem List in Lung Cancer Patients: A Cross-Sectional Study.Thoracic cancer · 2025Article
- Tandospirone augments cisplatin treatment by lowering cholesterol and managing distress in NSCLC patients.NPJ digital medicine · 2025Article
- Patient-focused insights: how emotional distress shapes immunotherapy response in non-small cell lung cancer.Translational lung cancer research · 2024Article
- The therapeutic potential of RNA m(6)A in lung cancer.Cell communication and signaling : CCS · 2024Review
- Association between pretreatment emotional distress and immune checkpoint inhibitor response in non-small-cell lung cancer.Nature medicine · 2024Observational
- A population-based analysis of the management of symptoms of depression among patients with stage IV non-small cell lung cancer (NSCLC) in Ontario, Canada.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Article
- Use of ketamine for depression and suicidality in cancer and terminal patients: Review of current data.AIMS public health · 2023Review
- Negative correlations of psychological distress with quality of life and immunotherapy efficacy in patients with advanced NSCLC.American journal of cancer research · 2022Article
- Experiences of Patients After Withdrawal From Cancer Clinical Trials.JAMA network open · 2021Article
- A Longitudinal Analysis of Inflammation and Depression in Patients With Metastatic Lung Cancer: Associations With Survival.Biological research for nursing · 2021Article
- The Sickness Behavior Inventory-Revised: Sickness behavior and its associations with depression and inflammation in patients with metastatic lung cancer.Palliative & supportive care · 2021Article
- Clinical Implications of Cancer Related Inflammation and Depression: A Critical Review.Clinical practice and epidemiology in mental health : CP & EMH · 2021Review
- Prognostic implications of depression and inflammation in patients with metastatic lung cancer.Future oncology (London, England) · 2021Article
- Improving Social Support to Increase QoL in Lung Cancer Patients.Cancer management and research · 2021Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
objectivesAmong lung cancer patients depression symptoms are common and impact outcomes. The aims of this study were to determine risk factors that contribute to persistent or new onset depression symptoms during lung cancer treatment, and examine interactions between depression symptoms and health domains that influence mortality. MATERIALS AND
methodsProspective observational study in five healthcare systems and 15 Veterans Affairs medical centers. Patients in the Cancer Care Outcomes Research and Surveillance (CanCORS) Consortium with lung cancer were eligible. The 8-item Center for Epidemiologic Studies Depression (CES-D) scale was administered at baseline and follow-up. Scores ≥4 indicated elevated depressive symptoms. Health domains were measured using validated instruments. We applied logistic regression and Cox proportional hazards modeling to explore the association between depression symptoms, health domains, and mortality.
resultsOf 1790 participants, 38% had depression symptoms at baseline and among those still alive, 31% at follow-up. Risk factors for depression symptoms at follow-up included younger age (OR=2.81), female sex (OR=1.59), low income (OR=1.45), not being married (OR=1.74) and current smoking status (OR=1.80); high school education was associated with reduced odds of depression symptoms at follow-up, compared with lesser educational attainment (OR=0.74) (all p values <0.05). Patients with depression symptoms had worse health-related quality of life, vitality, cancer-specific symptoms, and social support than patients without depression symptoms (all p<0.001). The association between depression symptoms and increased mortality is greater among patients with more lung cancer symptoms (p=0.008) or less social support (p=0.04).
conclusionsPatient risk factors for depression symptoms at follow-up were identified and these subgroups should be targeted for enhanced surveillance. Patients with depression symptoms suffer across all health domains; however, only more lung cancer symptoms or less social support are associated with worse mortality among these patients. These potentially modifiable health domains suggest targets for possible intervention in future studies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.