Evidence map›Paper›PMID 27597141›Full record

ArticleMolecular carcinogenesis2017

Single nucleotide variants in metastasis-related genes are associated with breast cancer risk, by lymph node involvement and estrogen receptor status, in women with European and African ancestry.

Michelle R Roberts, Lara E Sucheston-Campbell, Gary R Zirpoli, Michael Higgins, Jo L Freudenheim, Elisa V Bandera, Christine B Ambrosone, Song Yao

Abstract read
In one paragraph

Article in Molecular carcinogenesis, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Uncovering Evidence: Associations between Environmental Contaminants and Disparities in Women's Health.International journal of environmental research and public health · 2022
    Review
  5. Article
  6. Article
  7. Article
  8. Risk Factors and Preventions of Breast Cancer.International journal of biological sciences · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Michelle R RobertsChanning Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Lara E Sucheston-CampbellDivision of Pharmacy Practice and Science, The Ohio State University, Columbus, Ohio.
Gary R ZirpoliDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Michael HigginsDepartment of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, New York.
Jo L FreudenheimDepartment of Epidemiology and Environmental Health, University at Buffalo, Buffalo, New York.
Elisa V BanderaRutgers Cancer Institute of New Jersey, New Brunswick, New Jersey.
Christine B AmbrosoneDepartment of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York.
Song YaoDepartment of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York.
Roswell Park Comprehensive Cancer Center · USUniversity at Buffalo, State University of New York · USMassachusetts General Hospital · USRutgers Cancer Institute of New JerseyThe Ohio State University · US

Funding

TRANSCRIPTIONAL PROFILINGP30CA072720 · NCI · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI Chang S Chan · 1997 to 2026
$94.5M
Statistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI TWOROGER, SHELLEY S · 2000 to 2019
$77.8M
University of Buffalo Clinical and Translational Science Institute - Supplement SchulyerUL1TR001412 · NCATS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI MURPHY, TIMOTHY F · 2015 to 2024
$33.8M
Long Term Multidisciplinary Study of Cancer in Women: The Nurses Health StudyUM1CA186107 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER, STAMPFER, MEIR · 2014 to 2023
$22.3M
Reproduction, Lactation and Hormonal Factors in Breast Cancer SubtypesP01CA151135 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI AMBROSONE, CHRISTINE B., OLSHAN, ANDREW · 2011 to 2017
$18.1M
Training Program in Cancer EpidemiologyT32CA009001 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI A. Heather Eliassen, Meir Stampfer · 1985 to 2026
$17.3M
NEW JERSEY CANCER PREVENTION & CONTROL PROGRAMU58DP003931 · DP · NEW JERSEY STATE DEPT/HEALTH/SENIOR SRVS · PI RODRIQUEZ, GLORIA · 2012 to 2014
$11.9M
Obesity, related comorbidities, and breast cancer outcomes in African AmericansR01CA185623 · NCI · RBHS -CANCER INSTITUTE OF NEW JERSEY · PI BANDERA, ELISA V, DEMISSIE, KITAW · 2014 to 2018
$6.2M
Race &Risk Factors for Early/Aggressive Breast CancerR01CA100598 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI AMBROSONE, CHRISTINE B. · 2004 to 2008
$4.8M
Interdisciplinary Training in Cancer Epidemiology at UBR25CA113951 · NCI · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI FREUDENHEIM, JO L., MOYSICH, KIRSTEN B. · 2007 to 2016
$2.5M
Interdisciplinary Training in Cancer Epidemiology at UBT32CA113951 · NCI · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI FREUDENHEIM, JO L., MOYSICH, KIRSTEN B. · 2017 to 2021
$693k
NCATS NIH HHS UL1 TR001412NCCDPHP CDC HHS U58 DP003931NCI NIH HHS P01 CA087969NCI NIH HHS P01 CA151135NCI NIH HHS P30 CA072720NCI NIH HHS R01 CA100598NCI NIH HHS R01 CA185623NCI NIH HHS R25 CA113951NCI NIH HHS T32 CA009001NCI NIH HHS T32 CA113951NCI NIH HHS UM1 CA186107
6 · The paper itself

Abstract

Single nucleotide polymorphisms (SNPs) in pathways influencing lymph node (LN) metastasis and estrogen receptor (ER) status in breast cancer may partially explain inter-patient variability in prognosis. We examined 154 SNPs in 12 metastasis-related genes for associations with breast cancer risk, stratified by LN and ER status, in European-American (EA) and African-American (AA) women. Two-thousand six hundred and seventy-one women enrolled in the Women's Circle of Health Study were genotyped. Pathway analyses were conducted using the adaptive rank truncated product (ARTP) method, with p

Indexed as

Polymorphism, Single NucleotideAdultAgedBlack or African AmericanBlack PeopleBreast NeoplasmsFemaleGenetic Predisposition to DiseaseHumansLymph NodesMiddle AgedNeoplasm MetastasisReceptors, EstrogenWhite PeopleYoung AdultReceptors, EstrogenAfrican-Americanbreast neoplasmsestrogen receptorlymph nodessingle nucleotide polymorphism

Identifiers

PMID27597141
PMCPMC5310990
OpenAlexW2509144697

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.