ArticleLipids in health and disease2016
Diet change and exercise enhance protein expression of CREB, CRTC 2 and lipolitic enzymes in adipocytes of obese mice.
Article in Lipids in health and disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 19 citations in OpenAlex.
- Yeast hydrolysate and exercise ameliorate high-fat diet-induced obesity in C57BL/6 mice.BMC complementary medicine and therapies · 2025Article
- Navigating the Adipocyte Precursor Niche: Cell-Cell Interactions, Regulatory Mechanisms and Implications for Adipose Tissue Homeostasis.Journal of cellular signaling · 2024Article
- Effect of Resistance Exercise on the Lipolysis Pathway in Obese Pre- and Postmenopausal Women.Journal of personalized medicine · 2021Article
- Combination ofFrontiers in nutrition · 2021Article
- The Effects of Exercise on White and Brown Adipose Tissue Cellularity, Metabolic Activity and Remodeling.Frontiers in physiology · 2021Review
- Zhenqing recipe attenuates non-alcoholic fatty liver disease by regulating the SIK1/CRTC2 signaling in experimental diabetic rats.BMC complementary medicine and therapies · 2020Article
- Function and Transcriptional Regulation of BovineInternational journal of molecular sciences · 2019Article
- Effect of Exercise on Fatty Acid Metabolism and Adipokine Secretion in Adipose Tissue.Frontiers in physiology · 2019Review
- The effects of detraining and training on adipose tissue lipid droplet in obese mice after chronic high-fat diet.Lipids in health and disease · 2017Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe study investigated the effects of regular exercise and diet changes on the change in metabolic processes of the cAMP-Response Element-Binding Protein-Regulated Transcription Coactivator (CRTC) family and its sub-lipolysis.
methodsFour-week-old C57/black male mice received an 8-week diet of general formula (control, CO; n = 10) or a high fat diet (HF; n = 30) to induce obesity. Thereafter, the mice received another 8-week regimen of general formula CO (n = 10) diet, continuous HF diet (n = 10), switched to general formula (diet change, DC; n = 10) or switched to general formula + exercise (diet and exercise, DE; n = 10).
resultsThe DE group displayed significantly lower body weight, abdominal fat and lipid profiles (p < 0.05). The DE group also displayed significantly lower (35 %) CRTC 2 activity than the CO (p < 0.05). Activities of adipose triglyceride lipase (ATGL), hormone sensitive lipolitic enzyme (HSL) and monoacylglycerol lipase (MGL) were significantly higher (51 %, 38 %, 49 %) in the DE group than the HF group (p < 0.05). MGL, there were no differences between the CO group, HF group, and DC group, with the DE group (70 %) being significantly higher (p < 0.05).
conclusionChange in diet in the absence of exercise was not associated with changes in adipose tissue CRTC family lipase activity, indicating that lipolysis metabolic processes are effective only when diet and exercise are carried out together.
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