ArticleNature communications2016
Multiple novel gene-by-environment interactions modify the effect of FTO variants on body mass index.
Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
94 citing papers in PubMed, 5 syntheses or guidelines pooled it, 166 citations in OpenAlex.
- A Systematic Review of the Effect of Gene-Lifestyle Interactions on Metabolic-Disease-Related Traits in South Asian Populations.Nutrition reviews · 2025Pooled it
- In the context of the triple burden of malnutrition: A systematic review of gene-diet interactions and nutritional status.Critical reviews in food science and nutrition · 2024Pooled it
- FTO gene polymorphisms and obesity risk in Chinese population: a meta-analysis.World journal of pediatrics : WJP · 2019Pooled it
- Pooled it
- Ranking and characterization of established BMI and lipid associated loci as candidates for gene-environment interactions.PLoS genetics · 2017Pooled it
- Gene-environment interaction modifies the association between hyperinsulinemia and serum urate levels through SLC22A12.The Journal of clinical investigation · 2025Trial
- Identification of genetic loci affecting body mass index through interaction with multiple environmental factors using structured linear mixed model.Scientific reports · 2021Trial
- Genome-wide detection of genotype-environment interactions at biobank scale with fastGxE.Nature genetics · 2026Article
- Detecting gene-environment interactions to guide personalized intervention: Boosting distributional regression for polygenic scores.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Genetic Impacts on Variability of Body Fat Distribution Uncover Gene-Environment and Gene-Gene Interactions.bioRxiv : the preprint server for biology · 2026Article
- Environmental Determinants of Pediatric Obesity: An Epidemiological Review.Epidemiologia (Basel, Switzerland) · 2026Review
- Methods for modeling gene-environment interplay using polygenic risk scores.Statistical applications in genetics and molecular biology · 2026Review
- Performance of deep-learning-based approaches to improve polygenic scores.Nature communications · 2025Article
- Causal impact of genetically-determined fish and fish oil intake on epigenetic age acceleration and related serum markers.Human genomics · 2025Article
- Article
- Distinct explanations underlie gene-environment interactions in the UK Biobank.American journal of human genetics · 2025Article
- Evolution, genetic diversity, and health.Nature medicine · 2025Review
- Tradeoffs in Modeling Context Dependency in Complex Trait Genetics.bioRxiv : the preprint server for biology · 2025Article
- Multi-omics approaches for understanding gene-environment interactions in noncommunicable diseases: techniques, translation, and equity issues.Human genomics · 2025Review
- Article
34 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Genetic studies have shown that obesity risk is heritable and that, of the many common variants now associated with body mass index, those in an intron of the fat mass and obesity-associated (FTO) gene have the largest effect. The size of the UK Biobank, and its joint measurement of genetic, anthropometric and lifestyle variables, offers an unprecedented opportunity to assess gene-by-environment interactions in a way that accounts for the dependence between different factors. We jointly examine the evidence for interactions between FTO (rs1421085) and various lifestyle and environmental factors. We report interactions between the FTO variant and each of: frequency of alcohol consumption (P=3.0 × 10(-4)); deviations from mean sleep duration (P=8.0 × 10(-4)); overall diet (P=5.0 × 10(-6)), including added salt (P=1.2 × 10(-3)); and physical activity (P=3.1 × 10(-4)).
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.