Evidence map›Paper›PMID 27596704›Full record

ArticleContrast media & molecular imaging2016

Myelin-targeted, texaphyrin-based multimodal imaging agent for magnetic resonance and optical imaging.

Sashiprabha M Vithanarachchi, Casey D Foley, Sarah Trimpin, James R Ewing, Meser M Ali, Matthew J Allen

Open access · greenAbstract read
In one paragraph

Article in Contrast media & molecular imaging, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Review
  3. Imaging in the repair of peripheral nerve injury.Nanomedicine (London, England) · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Sashiprabha M VithanarachchiDepartment of Chemistry, Wayne State University, 5101 Cass Avenue, Detroit, 48202, MI, USA.
Casey D FoleyDepartment of Chemistry, Wayne State University, 5101 Cass Avenue, Detroit, 48202, MI, USA.
Sarah TrimpinDepartment of Chemistry, Wayne State University, 5101 Cass Avenue, Detroit, 48202, MI, USA.
James R EwingDepartment of Neurology, Henry Ford Hospital, Detroit, MI, 48202, USA.
Meser M AliDepartment of Neurology, Henry Ford Hospital, Detroit, MI, 48202, USA.
Matthew J AllenDepartment of Chemistry, Wayne State University, 5101 Cass Avenue, Detroit, 48202, MI, USA.
Wayne State University · USHenry Ford Hospital · USUniversity of Colombo · LK

Funding

Assessments of Multiple Breast Cancer Biomarkers with Dendritic MRI ProbesK25CA129173 · NCI · HENRY FORD HEALTH SYSTEM · PI ALI, MESER M. · 2009 to 2012
$518k
NCI NIH HHS K25 CA129173
6 · The paper itself

Abstract

Reliable methods of imaging myelin are essential to investigate the causes of demyelination and to study drugs that promote remyelination. Myelin-specific compounds can be developed into imaging probes to detect myelin with various imaging techniques. The development of multimodal myelin-specific imaging probes enables the use of orthogonal imaging techniques to accurately visualize myelin content and validate experimental results. Here, we describe the synthesis and application of multimodal myelin-specific imaging agents for light microscopy and magnetic resonance imaging. The imaging agents were synthesized by incorporating the structural features of luxol fast blue MBS, a myelin-specific histological stain, into texaphyrins coordinated to Gd

Indexed as

PorphyrinsAnimalsBrainContrast MediaGadoliniumMagnetic Resonance ImagingMiceMicroscopyMultimodal ImagingMyelin SheathOptical ImagingWhite MatterContrast MediaGadoliniumPorphyrinstexaphyrincontrast agentsgadoliniumMRImultimodal probesmyelinoptical imagingparamagnetic agentstexaphyrin

Identifiers

PMID27596704
PMCPMC5247309
OpenAlexW2520506809

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.