ArticleThe American journal of gastroenterology2017
Pan-Colonic Pressurizations Associated With Relaxation of the Anal Sphincter in Health and Disease: A New Colonic Motor Pattern Identified Using High-Resolution Manometry.
Article in The American journal of gastroenterology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.
- The Clinical Relevance of the Rectosigmoid Brake in Surgical Disorders and Therapies: A Systematic Review of Colonic Manometry Studies.Neurogastroenterology and motility · 2026Pooled it
- Trial
- Animal Models of Slow-Transit Constipation: Current Progress, Limitations, and Future Perspectives.Digestive diseases and sciences · 2026Review
- Article
- Physiology of lower gastrointestinal tract.Alimentary pharmacology & therapeutics · 2024Review
- Review
- Simultaneous Colonic Pressure Waves in Children and Young Adults with Gastrointestinal Motility Disorders: Artefact or Colonic Physiology?Journal of clinical medicine · 2023Article
- Altered Gut Microbic Flora and Haemorrhoids: Could They Have a Possible Relationship?Journal of clinical medicine · 2023Article
- Diagnosis of colonic dysmotility associated with autonomic dysfunction in patients with chronic refractory constipation.Scientific reports · 2022Article
- A descriptive study of high resolution total colonic intracavitary manometry and colonic transit test in the diagnostic efficacy of functional constipation in Chinese patients.BMC gastroenterology · 2022Article
- Understanding the physiology of human defaecation and disorders of continence and evacuation.Nature reviews. Gastroenterology & hepatology · 2021Review
- Bisacodyl: A review of pharmacology and clinical evidence to guide use in clinical practice in patients with constipation.Neurogastroenterology and motility · 2021Review
- The Sphincter of O'Beirne-Part 2: Report of a Case of Chronic Constipation with Autonomous Dyssynergia.Digestive diseases and sciences · 2021Article
- ManoMap: an automated system for characterization of colonic propagating contractions recorded by high-resolution manometry.Medical & biological engineering & computing · 2021Article
- Distal Colon Motor Coordination: The Role of the Coloanal Reflex and the Rectoanal Inhibitory Reflex in Sampling, Flatulence, and Defecation.Frontiers in medicine · 2021Article
- Novel Bionics Assessment of Anorectal Mechanosensory Physiology.Bioengineering (Basel, Switzerland) · 2020Review
- Distinct patterns of myogenic motor activity identified in isolated human distal colon with high-resolution manometry.Neurogastroenterology and motility · 2020Article
- On the nature of high-amplitude propagating pressure waves in the human colon.American journal of physiology. Gastrointestinal and liver physiology · 2020Article
- Management of functional constipation in children and adults.Nature reviews. Gastroenterology & hepatology · 2020Review
- Relationships Between Distention-, Butyrate- and Pellet-Induced Stimulation of Peristalsis in the Mouse Colon.Frontiers in physiology · 2020Article
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Authors and funding
8 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesOnly a few studies have applied high-resolution manometry (HRM) to the study of colonic motility in adults and none of them have concurrently evaluated colonic and anal motor activity. The aim of the study was to evaluate colonic and anal motor activity by means of HRM in healthy subjects. As the present study revealed the presence of a new colonic motor pattern (pan-colonic pressurizations) in healthy subjects, three additional studies were conducted: the first and the second to exclude that this motor event results from an artifact due to abdominal wall contraction and to confirm its modulation by cholinergic stimulation, and the third, as pilot study, to test the hypothesis that this colonic pattern is defective in patients with chronic constipation refractory to current pharmacological treatments.
methodsIn both volunteers and patients the HRM catheter was advanced proximally during colonoscopy.
resultsIn all subjects, pressure increases of 15±3 mm Hg and 24±4 s simultaneously occurring in all colonic sensors (pan-colonic pressurizations) and associated with anal sphincter relaxation were identified. Subjects had 85±38 pan-colonic pressurizations, which increased significantly during meal (P=0.007) and decreased afterward (P=0.01), and were correlated with feelings of and desire to evacuate gas. The mean number of propagating sequences was 47±39, and only retrograde increased significantly postprandially (P=0.01). Pan-colonic pressurizations differed from strain artifacts and significantly increased after prostigmine. In patients pan-colonic pressurizations were significantly reduced as compared with volunteers.
conclusionsPan-colonic pressurizations associated with relaxations of the anal sphincter represent a new colonic motor pattern that seems to be defective in patients with treatment-refractory chronic constipation and may have a role in the transport of colonic gas and in the facilitation of the propagating sequence-induced colonic transport.
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