Evidence map›Paper›PMID 27596539›Full record

ArticleVirology2016

A +1 ribosomal frameshifting motif prevalent among plant amalgaviruses.

Max L Nibert, Jesse D Pyle, Andrew E Firth

Abstract read
In one paragraph

Article in Virology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed.

  1. Article
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  15. Article
  16. Infection ofViruses · 2022
    Article
  17. Virome ofFrontiers in microbiology · 2022
    Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Max L NibertDepartment of Microbiology & Immunobiology, Harvard Medical School, Boston, MA 02115, USA; Harvard Ph.D. Program in Virology, Division of Medical Sciences, Harvard University, Boston, MA 02115, USA. Electronic address: mnibert@hms.harvard.edu.
Jesse D PyleHarvard Ph.D. Program in Virology, Division of Medical Sciences, Harvard University, Boston, MA 02115, USA. Electronic address: jessepyle@g.harvard.edu.
Andrew E FirthDivision of Virology, Department of Pathology, Addenbrooke's Hospital, University of Cambridge, Cambridge CB2 0QQ, UK. Electronic address: aef24@cam.ac.uk.

Funding

MOLECULAR BASIS OF VIRAL INFECTIVITYT32AI007245 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI Aaron Gregory Schmidt · 1985 to 2026
$11.3M
MICROSCOPY &IMAGE ANALYSIS OF UNSTAINED MACROMOLECULESR01GM033050 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BAKER, TIMOTHY S · 1985 to 2017
$4.3M
NIAID NIH HHS T32 AI007245NIGMS NIH HHS R01 GM033050Wellcome Trust
6 · The paper itself

Abstract

Sequence accessions attributable to novel plant amalgaviruses have been found in the Transcriptome Shotgun Assembly database. Sixteen accessions, derived from 12 different plant species, appear to encompass the complete protein-coding regions of the proposed amalgaviruses, which would substantially expand the size of genus Amalgavirus from 4 current species. Other findings include evidence for UUU_CGN as a +1 ribosomal frameshifting motif prevalent among plant amalgaviruses; for a variant version of this motif found thus far in only two amalgaviruses from solanaceous plants; for a region of α-helical coiled coil propensity conserved in a central region of the ORF1 translation product of plant amalgaviruses; and for conserved sequences in a C-terminal region of the ORF2 translation product (RNA-dependent RNA polymerase) of plant amalgaviruses, seemingly beyond the region of conserved polymerase motifs. These results additionally illustrate the value of mining the TSA database and others for novel viral sequences for comparative analyses.

Indexed as

Frameshifting, RibosomalNucleotide MotifsRNA, ViralBase SequenceCluster AnalysisCodonConserved SequenceGenome, ViralOpen Reading FramesPhylogenyPlant VirusesRNA, MessengerCodonRNA, MessengerRNA, ViralAmalgaviridaeCoiled coilDatabase miningdsRNA virusFungal virusPlant virusRibosomal frameshifting

Identifiers

PMID27596539
PMCPMC5052127

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.