ArticleScientific reports2016
Gamma radiation at a human relevant low dose rate is genotoxic in mice.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 44 citations in OpenAlex.
- Revealing DNA damage levels in rat testicular germ cells in vivo using an adapted version of the alkaline comet assay.Archives of toxicology · 2026Article
- Radiation-induced neurotoxicity: investigating human neuronal damage in MEA-integrated microfluidic platforms.RSC advances · 2026Article
- Radiation-Induced Neurodegeneration.Biomedicines · 2026Review
- Assessment of Tumor Relative Biological Effectiveness in Low-LET Proton Irradiation.Biomedicines · 2025Article
- Dose rate dependent reduction in chromatin accessibility at transcriptional start sites long time after exposure to gamma radiation.Epigenetics · 2023Article
- Article
- Article
- Gamma radiation in the mineral hot springs of Ardabil, Iran: Assessment of Environmental Dose Rate and health risk for swimmers.Environmental monitoring and assessment · 2020Article
- An Investigation of Post-radiation Gene Expression Profiles: A System Biology Study.Journal of lasers in medical sciences · 2020Article
- A systems biology approach reveals neuronal and muscle developmental defects after chronic exposure to ionising radiation in zebrafish.Scientific reports · 2019Article
- Restoration of Cognitive Performance in Mice Carrying a Deficient Allele of 8-Oxoguanine DNA Glycosylase by X-ray Irradiation.Neurotoxicity research · 2018Article
- DNA repair after oxidative stress: current challenges.Current opinion in toxicology · 2018Article
- Role of Ionizing Radiation in Neurodegenerative Diseases.Frontiers in aging neuroscience · 2018Review
- Genotoxic effects of high dose rate X-ray and low dose rate gamma radiation in ApcEnvironmental and molecular mutagenesis · 2017Article
- No cancer predisposition or increased spontaneous mutation frequencies in NEIL DNA glycosylases-deficient mice.Scientific reports · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 4 institutions in 2 countries.
Funding
Abstract
Even today, 70 years after Hiroshima and accidents like in Chernobyl and Fukushima, we still have limited knowledge about the health effects of low dose rate (LDR) radiation. Despite their human relevance after occupational and accidental exposure, only few animal studies on the genotoxic effects of chronic LDR radiation have been performed. Selenium (Se) is involved in oxidative stress defence, protecting DNA and other biomolecules from reactive oxygen species (ROS). It is hypothesised that Se deficiency, as it occurs in several parts of the world, may aggravate harmful effects of ROS-inducing stressors such as ionising radiation. We performed a study in the newly established LDR-facility Figaro on the combined effects of Se deprivation and LDR γ exposure in DNA repair knockout mice (Ogg1(-/-)) and control animals (Ogg1(+/-)). Genotoxic effects were seen after continuous radiation (1.4 mGy/h) for 45 days. Chromosomal damage (micronucleus), phenotypic mutations (Pig-a gene mutation of RBC(CD24-)) and DNA lesions (single strand breaks/alkali labile sites) were significantly increased in blood cells of irradiated animals, covering three types of genotoxic activity. This study demonstrates that chronic LDR γ radiation is genotoxic in an exposure scenario realistic for humans, supporting the hypothesis that even LDR γ radiation may induce cancer.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.