Evidence map›Paper›PMID 27596135›Full record

ArticleAtherosclerosis2016

Circulating progenitor cells and coronary microvascular dysfunction: Results from the NHLBI-sponsored Women's Ischemia Syndrome Evaluation - Coronary Vascular Dysfunction Study (WISE-CVD).

Girum Mekonnen, Salim S Hayek, Puja K Mehta, Qunna Li, Ernestine Mahar, Liping Mou, Tanya S Kenkre, John W Petersen, Babak Azarbal, Bruce Samuels and 12 more

Open access · greenAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Atherosclerosis, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Mechanisms of Vascular Aging.Circulation research · 2018
    Review
  7. Myocardial Ischemia and Mobilization of Circulating Progenitor Cells.Journal of the American Heart Association · 2018
    Article
  8. Acute myocardial infarction in young women: current perspectives.International journal of women's health · 2018
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 5 institutions in 2 countries.

Girum MekonnenEmory University School of Medicine, Atlanta, GA, USA.
Salim S HayekEmory University School of Medicine, Atlanta, GA, USA.
Puja K MehtaBarbra Streisand Women's Heart Center, Cedars-Sinai Heart Institute, Los Angeles, CA, USA.
Qunna LiEmory University School of Medicine, Atlanta, GA, USA.
Ernestine MaharEmory University School of Medicine, Atlanta, GA, USA.
Liping MouEmory University School of Medicine, Atlanta, GA, USA.
Tanya S KenkreUniversity of Pittsburgh, Pittsburgh, PA, USA.
John W PetersenUniversity of Florida, Gainesville, FL, USA.
Babak AzarbalBarbra Streisand Women's Heart Center, Cedars-Sinai Heart Institute, Los Angeles, CA, USA.
Bruce SamuelsBarbra Streisand Women's Heart Center, Cedars-Sinai Heart Institute, Los Angeles, CA, USA.
R David AndersonUniversity of Florida, Gainesville, FL, USA.
Tara SedlakUniversity of British Columbia, Canada.
Melody ZayaBarbra Streisand Women's Heart Center, Cedars-Sinai Heart Institute, Los Angeles, CA, USA.
Megha AgarwalBarbra Streisand Women's Heart Center, Cedars-Sinai Heart Institute, Los Angeles, CA, USA.
Afsaneh HaftbaradaranBarbra Streisand Women's Heart Center, Cedars-Sinai Heart Institute, Los Angeles, CA, USA.
Margo MinissianBarbra Streisand Women's Heart Center, Cedars-Sinai Heart Institute, Los Angeles, CA, USA.
Eileen HandbergUniversity of Florida, Gainesville, FL, USA.
Carl J PepineUniversity of Florida, Gainesville, FL, USA.
Christopher R CogleUniversity of Florida, Gainesville, FL, USA.
C Noel Bairey MerzBarbra Streisand Women's Heart Center, Cedars-Sinai Heart Institute, Los Angeles, CA, USA.
Edmund K WallerEmory University School of Medicine, Atlanta, GA, USA.
Arshed A QuyyumiEmory University School of Medicine, Atlanta, GA, USA. Electronic address: aquyyum@emory.edu.
Cedars-Sinai Smidt Heart Institute · USEmory University · USUniversity of Florida · USUniversity of British Columbia · CAUniversity of Pittsburgh · US

Funding

ZONA-FREE HAMSTER OVA ASSAY AS AN INDICATOR OF MALE FERTILITYM01RR000425 · NCRR · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI WANG, CHRISTINA C. · 1985 to 2011
$74.2M
Vascular Responses During Mental StressP01HL101398 · NHLBI · EMORY UNIVERSITY · PI BREMNER, JAMES DOUGLAS · 2010 to 2015
$11.0M
Women's Ischemia Syndrome Evaluation (WISE) Coronary Vascular DysfunctionR01HL090957 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI BAIREY MERZ, CATHLEEN NOEL, PEPINE, CARL J · 2008 to 2013
$3.5M
Behavioral Medicine and Cardiovascular Research TrainingT32HL069751 · NHLBI · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · PI KRANTZ, DAVID S. · 2003 to 2007
$1.2M
Cardiac Autonomic Function in WomenK23HL105787 · NHLBI · EMORY UNIVERSITY · PI MEHTA, PUJA KIRAN · 2012 to 2016
$813k
ISCHEMIC HEART DISEASE IN WOMEN--CLINICAL CENTERN01HV068163 · HV · UNIVERSITY OF FLORIDA · PI PEPINE, CARL J · 1996 to 2001
$386k
ISCHEMIC HEART DISEASE IN WOMEN-CLINICAL CENTERN01HV068161 · HV · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ROGERS, WILLIAM J · 1996 to 2000
$245k
Cardiovascular Events in Women's Ischemia Syndrome EvaluationR03AG032631 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KELSEY, SHERYL F · 2008 to 2009
$137k
EVAL OF ISCHEMIC HEART DISEASE IN WOMEN-CLINICAL CTRN01HV068164 · HV · ALLEGHENY-SINGER RESEARCH INSTITUTE · PI REICHEK, NATHANIEL · 1996 to 2001
–
EVAL OF ISCHEMIC HEART DISEASE IN WOMEN-CLINICAL CTR-N01HV68162-268068162N01HV068162 · HV · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 1996 to 2005
–
NCRR NIH HHS M01 RR000425NHLBI NIH HHS K23 HL105787NHLBI NIH HHS N01 HV068161NHLBI NIH HHS N01 HV068162NHLBI NIH HHS N01 HV068163NHLBI NIH HHS N01 HV068164NHLBI NIH HHS P01 HL101398NHLBI NIH HHS R01 HL090957NHLBI NIH HHS T32 HL069751NIA NIH HHS R03 AG032631
6 · The paper itself

Abstract

BACKGROUND AND

aimsIschemia stimulates a reparative response resulting in mobilization of circulating progenitor cells (CPCs). We hypothesized that women with chronic myocardial ischemia from coronary microvascular disease (CMD) will mobilize CPCs.

methodsIn 123 women with ischemic symptoms and signs but no obstructive coronary artery disease (CAD) enrolled in the Women's Ischemia Syndrome Evaluation - Coronary Vascular Dysfunction Study (WISE-CVD), we measured coronary flow reserve (CFR) in response to intracoronary adenosine. Peripheral blood CPCs were measured using flow cytometry for expression of CD34, CD133, CXCR4, and VEGFR2.

resultsSubjects were 53 ± 11 years, BMI 30 ± 8; 44% hypertensive, 11% diabetic, 23% hyperlipidemic and 7% smokers. Lower CFR correlated inversely with higher levels of hematopoietic-enriched CD34+ (r = -0.23, p = 0.011), CD34+/CD133+ (r = -0.24, p = 0.008), and CD34+/CXCR4+ (r = -0.19, p = 0.036) cells. In multivariable regression analyses, after adjusting for traditional cardiovascular risk factors, lower CFR remained significantly associated with elevated levels of CD34+ (β -0.18, p = 0.042), CD34+/CD133+ (β -0.24, p = 0.036), and CD34+/CXCR4+ (β -0.22, p = 0.050) cells. We found no association between CFR and CD34+/VEGFR2+ cells.

conclusionsIn women with non-obstructive CAD, impaired CFR is associated with higher levels of CPCs, suggesting that chronic myocardial ischemia from CMD stimulates CPC mobilization. The functional significance of elevated CPCs in these subjects requires further investigation as a potential biomarker and treatment target.

Indexed as

AgedAngiographyBiomarkersComorbidityCoronary Artery DiseaseCoronary CirculationFemaleHematopoietic Stem Cell MobilizationHumansIschemiaMicrocirculationMiddle AgedMyocardial IschemiaNational Heart, Lung, and Blood Institute (U.S.)Risk FactorsStem CellsBiomarkersCirculating progenitor cellsCoronary flow reserveMicrovascular function

Identifiers

PMID27596135
PMCPMC9197325
OpenAlexW2517729029

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.