Evidence map›Paper›PMID 27595995›Full record

ArticleJournal of medical genetics2016

PALB2, CHEK2 and ATM rare variants and cancer risk: data from COGS.

Melissa C Southey, David E Goldgar, Robert Winqvist, Katri Pylkäs, Fergus Couch, Marc Tischkowitz, William D Foulkes, Joe Dennis, Kyriaki Michailidou, Elizabeth J van Rensburg and 318 more

Open access · hybridAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medical genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 118 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
118citing papers in PubMed, 8 pooled it
22.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

118 citing papers in PubMed, 8 syntheses or guidelines pooled it, 217 citations in OpenAlex.

  1. Guideline
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Summary ofGenes · 2020
    Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Trial
  10. Tumor, germline, and paired testing in oncology: practical considerations.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Article
  11. Article
  12. Risk-Reducing Mastectomy inJournal of breast cancer · 2026
    Review
  13. Article
  14. Review
  15. Review
  16. Article
  17. Associations betweenJournal of medical genetics · 2025
    Article
  18. Article
  19. Article
  20. Translational breast cancer research : a journal focusing on translational research in breast cancer · 2025
    Review

58 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

328 authors at 20 institutions in 23 countries.

Melissa C SoutheyGenetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne, Melbourne, Australia.
David E GoldgarHuntsman Cancer Institute, Salt Lake City, UT, USA.
Robert WinqvistLaboratory of Cancer Genetics and Tumor Biology, Cancer and Translational Medicine Research Unit and Biocenter Oulu, University of Oulu, Nordlab Oulu, Oulu, Finland.
Katri PylkäsLaboratory of Cancer Genetics and Tumor Biology, Cancer and Translational Medicine Research Unit and Biocenter Oulu, University of Oulu, Nordlab Oulu, Oulu, Finland.
Fergus CouchDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
Marc TischkowitzDepartment of Medical Genetics and National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge, and the Department of Clinical Genetics, East Anglian Regional Genetics Service, Addenbrooke's Hospital.
William D FoulkesProgram in Cancer Genetics, Department of Human Genetics and Oncology, Lady Davis Institute, and Research Institute, McGill University Health Centre, McGill University, Montreal, Canada.
Joe DennisCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Laboratory, Worts Causeway, Cambridge, UK.
Kyriaki MichailidouCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Laboratory, Worts Causeway, Cambridge, UK.
Elizabeth J van RensburgDepartment of Genetics, University of Pretoria, South Africa.
Tuomas HeikkinenDepartment of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
Heli NevanlinnaDepartment of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
John L HopperCentre for Epidemiology and Biostatistics, School of Population and Global Health, The University of Melbourne, Melbourne, Australia.
Thilo DörkGynaecology Research Unit, Hannover Medical School, Hannover, Germany.
Kathleen Bm ClaesCenter for Medical Genetics, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium.
Jorge Reis-FilhoDepartment of Pathology and Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.
Zhi Ling TeoGenetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne, Melbourne, Australia.
Paolo RadiceUnit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy.
Irene CatucciIFOM, the FIRC Institute of Molecular Oncology, Milan, Italy.
Paolo PeterlongoIFOM, the FIRC Institute of Molecular Oncology, Milan, Italy.
Helen TsimiklisGenetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne, Melbourne, Australia.
Fabrice A OdefreyGenetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne, Melbourne, Australia.
James G DowtyCentre for Epidemiology and Biostatistics, School of Population and Global Health, The University of Melbourne, Melbourne, Australia.
Marjanka K SchmidtNetherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands.
Annegien BroeksNetherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands.
Frans B HogervorstNetherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands.
Senno VerhoefNetherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands.
Jane CarpenterAustralian Breast Cancer Tissue Bank, University of Sydney at the Westmead Institute for Medical Research, NSW, Australia.
Christine ClarkeCentre for Cancer Research, University of Sydney at the Westmead Institute for Medical Research, NSW, Australia.
Rodney J ScottDivision of Molecular Medicine, Pathology North, Newcastle and University of Newcastle, NSW, Australia.
Peter A FaschingUniversity Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany.
Lothar HaeberleUniversity Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany.
Arif B EkiciInstitute of Human Genetics, University Hospital Erlangen, Friedrich Alexander University Erlangen-Nuremberg, Erlangen, Germany.
Matthias W BeckmannUniversity Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany.
Julian PetoNon-communicable Disease Epidemiology Department, London School of Hygiene and Tropical Medicine, London, UK.
Isabel Dos-Santos-SilvaNon-communicable Disease Epidemiology Department, London School of Hygiene and Tropical Medicine, London, UK.
Olivia FletcherBreakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK.
Nichola JohnsonBreakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK.
Manjeet K BollaCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Laboratory, Worts Causeway, Cambridge, UK.
Elinor J SawyerDivision of Cancer Studies, NIHR Comprehensive Biomedical Research Centre, Guy's & St. Thomas' NHS Foundation Trust in partnership with King's College London, London, UK.
Ian TomlinsonWellcome Trust Centre for Human Genetics and Oxford Biomedical Research Centre, University of Oxford, UK and Oxford NIHR Biomedical Research Centre, Headington, OX3 7LE.
Michael J KerinSurgery, Lambe Institute for Translational Science, NUIGalway, University Hospital Galway, Galway, Ireland.
Nicola MillerSurgery, Lambe Institute for Translational Science, NUIGalway, University Hospital Galway, Galway, Ireland.
Federik MarmeDepartment of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany.
Barbara BurwinkelDepartment of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany.
Rongxi YangDepartment of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany.
Pascal GuénelInserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, Villejuif, France.
Thérèse TruongInserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, Villejuif, France.
Florence MenegauxInserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, Villejuif, France.
Marie SanchezInserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, Villejuif, France.
Stig BojesenCopenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, Copenhagen, Denmark.
Sune F NielsenCopenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, Copenhagen, Denmark.
Henrik FlygerDepartment of Breast Surgery, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark.
Javier BenitezHuman Genetics Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
M Pilar ZamoraServicio de Oncología Médica, Hospital Universitario La Paz, Madrid, Spain.
Jose Ignacio Arias PerezServicio de Cirugía General y Especialidades, Hospital Monte Naranco, Oviedo, Spain.
Primitiva MenéndezServicio de Anatomía Patológica, Hospital Monte Naranco, Oviedo, Spain.
Hoda Anton-CulverDepartment of Epidemiology, University of California Irvine, Irvine, California, USA.
Susan NeuhausenBeckman Research Institute of City of Hope, Duarte, California, USA.
Argyrios ZiogasDepartment of Epidemiology, University of California Irvine, Irvine, California, USA.
Christina A ClarkeCancer Prevention Institute of California, Fremont, California, USA.
Hermann BrennerDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Volker ArndtDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Christa StegmaierSaarland Cancer Registry, Saarbrücken, Germany.
Hiltrud BrauchGerman Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Thomas BrüningInstitute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University, Bochum (IPA), Germany.
Yon-Dschun KoDepartment of Internal Medicine, Evangelische Kliniken Bonn gGmbH, Johanniter Krankenhaus, Bonn, Germany.
Taru A MuranenDepartment of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
Kristiina AittomäkiDepartment of Clinical Genetics, Helsinki University Central Hospital, Helsinki, Finland.
Carl BlomqvistDepartment of Oncology, Helsinki University Central Hospital, Helsinki, Finland.
Natalia V BogdanovaGynaecology Research Unit, Hannover Medical School, Hannover, Germany.
Natalia N AntonenkovaN.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus.
Annika LindblomDepartment of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
Sara MargolinDepartment of Oncology - Pathology, Karolinska Institutet, Stockholm, Sweden.
Arto MannermaaSchool of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, and Cancer Center of Eastern Finland, University of Eastern Finland, Kuopio, Finland.
Vesa KatajaSchool of Medicine, Institute of Clinical Medicine, Oncology, University of Eastern Finland, Kuopio, Finland.
Veli-Matti KosmaSchool of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, and Cancer Center of Eastern Finland, University of Eastern Finland, Kuopio, Finland.
Jaana M HartikainenSchool of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, and Cancer Center of Eastern Finland, University of Eastern Finland, Kuopio, Finland.
Amanda B SpurdleQIMR Berghofer Medical Research Institute, Brisbane, Australia.
kConFab InvestigatorsResearch Department, Peter MacCallum Cancer Centre and The Sir Peter MacCallum Department of Oncology, University of Melbourne, Victoria, Australia.
Australian Ovarian Cancer Study Group
Els WautersVesalius Research Center (VRC), VIB, Leuven, Belgium.
Dominiek SmeetsVesalius Research Center (VRC), VIB, Leuven, Belgium.
Benoit BeuselinckUniversity Hospital Gasthuisberg, Leuven, Belgium.
Giuseppe FlorisUniversity Hospital Gasthuisberg, Leuven, Belgium.
Jenny Chang-ClaudeDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Anja RudolphDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Petra SeiboldDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Dieter Flesch-JanysDepartment of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, University Clinic Hamburg-Eppendorf, Hamburg, Germany.
Janet E OlsonDepartment of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
Celine VachonDepartment of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
Vernon S PankratzDepartment of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
Catriona McLeanAnatomical Pathology, The Alfred Hospital, Melbourne, Australia.
Christopher A HaimanDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Brian E HendersonDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Fredrick SchumacherDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Loic Le MarchandEpidemiology Program, Cancer Research Center, University of Hawaii, Honolulu, HI, USA.
Vessela KristensenDepartment of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo, Norway.
Grethe Grenaker AlnæsDepartment of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo, Norway.
Wei ZhengDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA.
David J HunterProgram in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, MA, USA.
Sara LindstromProgram in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, MA, USA.
Susan E HankinsonDepartment of Epidemiology, Harvard School of Public Health, Boston, MA, USA.
Peter KraftProgram in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, MA, USA.
Irene AndrulisOntario Cancer Genetics Network, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada.
Julia A KnightProsserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada.
Gord GlendonOntario Cancer Genetics Network, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada.
Anna Marie MulliganDepartment of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.
Arja Jukkola-VuorinenDepartment of Oncology, Oulu University Hospital, University of Oulu, Oulu, Finland.
Mervi GripDepartment of Surgery, Oulu University Hospital, University of Oulu, Oulu, Finland.
Saila KauppilaDepartment of Pathology, Oulu University Hospital, University of Oulu, Oulu, Finland.
Peter DevileeDepartment of Surgical Oncology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.
Robert A E M TollenaarDepartment of Surgical Oncology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.
Caroline SeynaeveFamily Cancer Clinic, Department of Medical Oncology, Erasmus MC-Daniel den Hoed Cancer Centre, Rotterdam, The Netherlands.
Antoinette HollestelleFamily Cancer Clinic, Department of Medical Oncology, Erasmus MC-Daniel den Hoed Cancer Centre, Rotterdam, The Netherlands.
Montserrat Garcia-ClosasThe Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, SW3 6JB, UK.
Jonine FigueroaDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA.
Stephen J ChanockDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA.
Jolanta LissowskaDepartment of Cancer Epidemiology and Prevention, M. Sklodowska-Curie Memorial Cancer Center & Institute of Oncology, Warsaw, Poland.
Kamila CzeneDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden.
Hatef DarabiDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden.
Mikael ErikssonDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden.
Diana M EcclesFaculty of Medicine, University of Southampton (UoS), Southampton UK.
Sajjad RafiqFaculty of Medicine, University of Southampton (UoS), Southampton UK.
William J TapperFaculty of Medicine, University of Southampton (UoS), Southampton UK.
Sue M GertyFaculty of Medicine, University of Southampton (UoS), Southampton UK.
Maartje J HooningDepartment of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
John W M MartensDepartment of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
J Margriet ColléeDepartment of Clinical Genetics, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, The Netherlands.
Madeleine Tilanus-LinthorstDepartment of Surgical Oncology, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, The Netherlands.
Per HallDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden.
Jingmei LiHuman Genetics Division, Genome Institute of Singapore, Singapore 138672, Singapore.
Judith S BrandDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden.
Keith HumphreysDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden.
Angela CoxSheffield Cancer Research, Department of Oncology, University of Sheffield, Sheffield, UK.
Malcolm W R ReedSheffield Cancer Research, Department of Oncology, University of Sheffield, Sheffield, UK.
Craig LuccariniCentre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
Caroline BaynesCentre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
Alison M DunningCentre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
Ute HamannMolecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Diana TorresMolecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Hans Ulrich UlmerFrauenklinik der Stadtklinik Baden-Baden, Baden-Baden, Germany.
Thomas RüdigerInstitute of Pathology, Städtisches Klinikum Karlsruhe, Karlsruhe, Germany.
Anna JakubowskaDepartment of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Jan LubinskiDepartment of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Katarzyna JaworskaDepartment of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Katarzyna DurdaDepartment of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Susan SlagerDepartment of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
Amanda E TolandDepartment of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.
Christine B AmbrosoneRoswell Park Cancer Institute, Buffalo, New York, USA.
Drakoulis YannoukakosMolecular Diagnostics Laboratory, IRRP, National Centre for Scientific Research "Demokritos", Aghia Paraskevi Attikis, Athens, Greece.
Anthony SwerdlowDivision of Genetics and Epidemiology, Institute of Cancer Research, London, UK.
Alan AshworthThe Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, SW3 6JB, UK.
Nick OrrThe Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, SW3 6JB, UK.
Michael JonesDivision of Genetics and Epidemiology, Institute of Cancer Research, London, UK.
Anna González-NeiraHuman Genetics Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
Guillermo PitaHuman Genetics Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
M Rosario AlonsoHuman Genetics Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
Nuria ÁlvarezHuman Genetics Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
Daniel HerreroHuman Genetics Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
Daniel C TessierCentre d'innovation Genome Quebec et University McGill Montreal Quebec, Canada.
Daniel VincentMcGill University, Montreal, Quebec, Canada.
Francois BacotMcGill University, Montreal, Quebec, Canada.
Jacques SimardCancer Genomics Laboratory, Centre Hospitalier Universitaire de Quebec Research Center. Laval University, Quebec, Canada.
Martine DumontCancer Genomics Laboratory, Centre Hospitalier Universitaire de Quebec Research Center. Laval University, Quebec, Canada.
Penny SoucyCancer Genomics Laboratory, Centre Hospitalier Universitaire de Quebec Research Center. Laval University, Quebec, Canada.
Rosalind EelesThe Institute of Cancer Research, London, SM2 5NG, UK.
Kenneth MuirUniversity of Warwick, Coventry, UK.
Fredrik WiklundDepartment of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.
Henrik GronbergDepartment of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.
Johanna SchleutkerDepartment of Medical Biochemistry and Genetics, University of Turku, and Tyks Microbiology and Genetics, Department of Medical Genetics, Turku University Hospital, Turku, Finland.
Børge G NordestgaardDepartment of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev Ringvej 75, DK-2730 Herlev, Denmark.
Maren WeischerDepartment of Human Genetics University of Utah, Salt Lake City, UT, USA and Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, Copenhagen, Denmark.
Ruth C TravisCancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
David NealSurgical Oncology (Uro-Oncology: S4), University of Cambridge, Box 279, Addenbrooke's Hospital, Hills Road, Cambridge, UK and Cancer Research UK Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK.
Jenny L DonovanProfessor of Social Medicine, University of Bristol, Canynge Hall, 39 Whatley Road, Bristol BS8 2PS.
Freddie C HamdyNuffield Department of Surgical Sciences, Old Road Campus Research Building (off Roosevelt Drive), University of Oxford, Headington, Oxford, OX3 7DQ.
Kay-Tee KhawCambridge Institute of Public Health, University of Cambridge, Forvie Site, Robinson Way, Cambridge CB2 0SR.
Janet L StanfordDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
William J BlotInternational Epidemiology Institute, 1455 Research Blvd., Suite 550, Rockville, MD 20850.
Stephen ThibodeauDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
Daniel J SchaidDepartment of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
Joseph L KelleyDepartment of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Christiane MaierDepartment of Urology, University Hospital Ulm, Germany.
Adam S KibelBrigham and Women's Hospital/Dana-Farber Cancer Institute, 45 Francis Street- ASB II-3, Boston, MA 02115.
Cezary CybulskiInternational Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Lisa Cannon-AlbrightDivision of Genetic Epidemiology, Department of Medicine, University of Utah School of Medicine.
Katja ButterbachDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Jong ParkDivision of Cancer Prevention and Control, H. Lee Moffitt Cancer Center, 12902 Magnolia Dr., Tampa, Florida, USA.
Radka KanevaMolecular Medicine Center and Department of Medical Chemistry and Biochemistry, Medical University - Sofia, 2 Zdrave St, 1431, Sofia, Bulgaria.
Jyotsna BatraAustralian Prostate Cancer Research Centre-Qld, Institute of Health and Biomedical Innovation and Schools of Life Science and Public Health, Queensland University of Technology, Brisbane, Australia.
Manuel R TeixeiraDepartment of Genetics, Portuguese Oncology Institute, Porto, Portugal and Biomedical Sciences Institute (ICBAS), Porto University, Porto, Portugal.
Zsofia Kote-JaraiThe Institute of Cancer Research, London, SM2 5NG, UK.
Ali Amin Al OlamaCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Laboratory, Worts Causeway, Cambridge, UK.
Sara BenllochCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Laboratory, Worts Causeway, Cambridge, UK.
Stefan P RennerUniversity Hospital Erlangen, Department of Gynecology and Obstetrics, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Universitaetsstrasse 21-23, 91054 Erlangen, Germany.
Arndt HartmannUniversity Hospital Erlangen, Institute of Pathology, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Universitaetsstrasse 21-23, 91054 Erlangen, German.
Alexander HeinUniversity Hospital Erlangen, Department of Gynecology and Obstetrics, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Universitaetsstrasse 21-23, 91054 Erlangen, Germany.
Matthias RuebnerUniversity Hospital Erlangen, Department of Gynecology and Obstetrics, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Universitaetsstrasse 21-23, 91054 Erlangen, Germany.
Diether LambrechtsVesalius Research Center, VIB, Leuven, Belgium.
Els Van NieuwenhuysenDepartment of Epidemiology, The Geisel School of Medicine at Dartmouth, Lebanon, NH, USA.
Ignace VergoteDepartment of Epidemiology, The Geisel School of Medicine at Dartmouth, Lebanon, NH, USA.
Sandrina LambretchsDepartment of Epidemiology, The Geisel School of Medicine at Dartmouth, Lebanon, NH, USA.
Jennifer A DohertyDepartment of Epidemiology, The Geisel School of Medicine at Dartmouth, Hannover, NH, USA.
Mary Anne RossingProgram in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Stefan NickelsGerman Cancer Research Center, Division of Cancer Epidemiology, Heidelberg, Germany.
Ursula EilberGerman Cancer Research Center, Division of Cancer Epidemiology, Heidelberg, Germany.
Shan Wang-GohrkeDepartment of Obstetrics and Gynecology, University of Ulm, Ulm, Germany.
Kunle OdunsiDepartment of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY.
Lara E Sucheston-CampbellDepartment of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY.
Grace FrielDepartment of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY.
Galina LurieCancer Epidemiology Program, University of Hawaii Cancer Center, Hawaii, USA.
Jeffrey L KilleenDepartment of Pathology, Kapiolani Medical Center for Women and Children, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii 96826, USA.
Lynne R WilkensCancer Epidemiology Program, University of Hawaii Cancer Center, Hawaii, USA.
Marc T GoodmanCancer Prevention and Control, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Ingo RunnebaumDepartment of Gynecology and Obstetrics, Friedrich Schiller University, Jena University Hospital, Jena, Germany.
Peter A HillemannsClinics of Obstetrics and Gynaecology, Hannover Medical School, Hannover, Germany.
Liisa M PelttariDepartment of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
Ralf ButzowDepartment of Pathology, Helsinki University Central Hospital, Helsinki, 00029 HUS, Finland.
Francesmary ModugnoUniversity of Pittsburgh Department of Obstetrics, Gynecology and Reproductive Sciences and Ovarian Cancer Center of Excellence Pittsburgh PA USA.
Robert P EdwardsDepartment of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Roberta B NessThe University of Texas School of Public Health, Houston, TX, USA.
Kirsten B MoysichDepartment of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY.
Andreas du BoisDepartment of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte/ Evang. Huyssens-Stiftung/ Knappschaft GmbH, Essen, Germany.
Florian HeitzDepartment of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte/ Evang. Huyssens-Stiftung/ Knappschaft GmbH, Essen, Germany.
Philipp HarterDepartment of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte/ Evang. Huyssens-Stiftung/ Knappschaft GmbH, Essen, Germany.
Stefan KommossDepartment of Gynecology and Gynecologic Oncology, Dr. Horst Schmidt Kliniken Wiesbaden, Wiesbaden, Germany.
Beth Y KarlanWomen's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California.
Christine WalshWomen's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California.
Jenny LesterWomen's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California.
Allan JensenDepartment of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark.
Susanne Krüger KjaerDepartment of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark.
Estrid HøgdallDepartment of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark.
Bernard PeisselUnit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy.
Bernardo BonanniDivision of Cancer Prevention and Genetics, Istituto Europeo di Oncologia (IEO), Milan, Italy.
Loris BernardDepartment of Experimental Oncology, Istituto Europeo di Oncologia (IEO), Milan, Italy and Cogentech Cancer Genetic Test Laboratory, Milan, Italy.
Ellen L GoodeDepartment of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
Brooke L FridleyUniversity of Kansas Medical Center, Kansas City, KS, USA.
Robert A VierkantDepartment of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
Julie M CunninghamDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
Melissa C LarsonDepartment of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
Zachary C FogartyDepartment of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
Kimberly R KalliDepartment of Medical Oncology, Mayo Clinic, Rochester, Minnesota, USA.
Dong LiangCollege of Pharmacy and Health Sciences, Texas Southern University, Houston, Texas, USA.
Karen H LuDepartment of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Michelle A T HildebrandtDepartment of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Xifeng WuDepartment of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Douglas A LevineGynecology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Fanny DaoGynecology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Maria BisognaGynecology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Andrew BerchuckDepartment of Obstetrics and Gynecology, Duke University Medical Center, Durham, North Carolina, USA.
Edwin S IversenDepartment of Statistical Science, Duke University, Durham, North Carolina, USA.
Jeffrey R MarksDepartment of Surgery, Duke University Medical Center, Durham, North Carolina, USA.
Lucy AkushevichCancer Prevention, Detection & Control Research Program, Duke Cancer Institute, Durham, North Carolina, USA.
Daniel W CramerObstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Joellen SchildkrautCancer Prevention, Detection & Control Research Program, Duke Cancer Institute, Durham, North Carolina, USA.
Kathryn L TerryObstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Elizabeth M PooleChanning Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School.
Meir StampferDepartment of Epidemiology, Harvard School of Public Health, Boston, MA, USA.
Shelley S TworogerChanning Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School.
Elisa V BanderaCancer Prevention and Control Program, Rutgers Cancer Institute of New Jersey, The State University of New Jersey, New Brunswick, NJ, USA.
Irene OrlowDepartment of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Sara H OlsonDepartment of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Line BjorgeDepartment of Gynecology and Obstetrics, Haukeland University Horpital, Bergen, Norway.
Helga B SalvesenDepartment of Gynecology and Obstetrics, Haukeland University Horpital, Bergen, Norway.
Anne M van AltenaRadboud university medical center, Department of Gynaecology, Nijmegen, Netherlands.
Katja K H AbenRadboud university medical centre, Radboud Institute for Health Sciences, Nijmegen, Netherlands.
Lambertus A KiemeneyRadboud university medical centre, Radboud Institute for Health Sciences, Nijmegen, Netherlands.
Leon F A G MassugerRadboud university medical center, Department of Gynaecology, Nijmegen, Netherlands.
Tanja PejovicKnight Cancer Institute, Oregon Health & Science University, Portland, Oregon, USA.
Yukie BeanKnight Cancer Institute, Oregon Health & Science University, Portland, Oregon, USA.
Angela Brooks-WilsonCanada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, BC, Canada.
Linda E KelemenDepartment of Public Health Sciences, College of Medicine, Medical University of South Carolina, SC, USA.
Linda S CookDivision of Epidemiology and Biostatistics, Department of Internal Medicine, University of New Mexico, Albuquerque, New Mexico, USA.
Nhu D LeCancer Control Research, BC Cancer Agency, Vancouver, BC, Canada.
Bohdan GórskiInternational Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Jacek GronwaldInternational Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Janusz MenkiszakDepartment of Gynecological Surgery and Gynecological Oncology of Adults and Adolescents, Pomeranian Medical University, Szczecin, Poland.
Claus K HøgdallDepartment of Obstetrics and Gynecology, Rigshospitalet, Copenhagen, Denmark.
Lene LundvallGyn Clinic, Rigshospitalet, University of Copenhagen, Denmark.
Lotte NedergaardDepartment of Pathology, Rigshospitalet, University of Copenhagen, Denmark.
Svend Aage EngelholmDepartment of Oncology, Rigshospitalet, University of Copenhagen, Denmark.
Ed DicksDepartment of Oncology, University of Cambridge, Strangeways Research laboratory, Cambridge, UK.
Jonathan TyrerDepartment of Oncology, University of Cambridge, Strangeways Research laboratory, Cambridge, UK.
Ian CampbellCancer Genetics Laboratory, Research Division, Peter MacCallum Cancer Centre, St Andrews Place, East Melbourne.
Iain McNeishInstitute of Cancer Sciences, University of Glasgow, Wolfson Wohl Cancer Research Centre, Beatson Institute for Cancer Research, Glasgow, UK.
James PaulThe Cancer Research UK Clinical Trials Unit, Beatson West of Scotland Cancer Centre, 1053 Great Western Road, Glasgow, G12 0YN.
Nadeem SiddiquiDepartment of Gynaecological Oncology, Glasgow Royal Infirmary.
Rosalind GlasspoolDepartment of Gynaecological Oncology, Glasgow Royal Infirmary.
Alice S WhittemoreDepartment of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford CA, USA.
Joseph H RothsteinDepartment of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford CA, USA.
Valerie McGuireDepartment of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford CA, USA.
Weiva SiehDepartment of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford CA, USA.
Hui CaiDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA.
Xiao-Ou ShuDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA.
Rachel T TetenEpidemiology Center, College of Medicine, University of South Florida, Tampa, Florida, USA.
Rebecca SutphenEpidemiology Center, College of Medicine, University of South Florida, Tampa, Florida, USA.
John R McLaughlinPublic Health Ontario, Toronto, Canada.
Steven A NarodWomen's College Research Institute, University of Toronto, Toronto, Ontario, Canada.
Catherine M PhelanDepartment of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL, USA.
Alvaro N MonteiroDepartment of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL, USA.
David FenstermacherDepartment of Biostatistics and Bioinformatics, Moffitt Cancer Center, Tampa, FL, USA.
Hui-Yi LinDepartment of Biostatistics and Bioinformatics, Moffitt Cancer Center, Tampa, FL, USA.
Jennifer B PermuthDepartment of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL, USA.
Thomas A SellersDepartment of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL, USA.
Y Ann ChenDepartment of Biostatistics and Bioinformatics, Moffitt Cancer Center, Tampa, FL, USA.
Ya-Yu TsaiDepartment of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL, USA.
Zhihua ChenDepartment of Biostatistics and Bioinformatics, Moffitt Cancer Center, Tampa, FL, USA.
Aleksandra Gentry-MaharajWomen's Cancer, Institute for Women's Health, UCL, London, United Kingdom.
Simon A GaytherDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA.
Susan J RamusDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA.
Usha MenonWomen's Cancer, Institute for Women's Health, UCL, London, United Kingdom.
Anna H WuDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA.
Celeste L PearceDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA.
David Van Den BergDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA.
Malcolm C PikeDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA.
Agnieszka Dansonka-MieszkowskaDepartment of Pathology and Laboratory Diagnostics, The Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland.
Joanna Plisiecka-HalasaDepartment of Pathology and Laboratory Diagnostics, The Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland.
Joanna Moes-SosnowskaDepartment of Pathology and Laboratory Diagnostics, The Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland.
Jolanta KupryjanczykDepartment of Pathology and Laboratory Diagnostics, The Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland.
Paul Dp PharoahDepartment of Oncology, University of Cambridge, Strangeways Research laboratory, Cambridge, UK.
Honglin SongDepartment of Oncology, University of Cambridge, Strangeways Research laboratory, Cambridge, UK.
Ingrid WinshipDepartment of Medicine, The University of Melbourne Health, Australia.
Georgia Chenevix-TrenchQIMR Berghofer Medical Research Institute, Brisbane, Australia.
Graham G GilesCentre for Epidemiology and Biostatistics, School of Population and Global Health, The University of Melbourne, Melbourne, Australia.
Sean V TavtigianHuntsman Cancer Institute, Salt Lake City, UT, USA.
Doug F EastonCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Laboratory, Worts Causeway, Cambridge, UK.
Roger L MilneCentre for Epidemiology and Biostatistics, School of Population and Global Health, The University of Melbourne, Melbourne, Australia.
University of Cambridge · GBGerman Cancer Research Center · DEKarolinska Institutet · SEUniversity of Southern California · USInstitute of Cancer Research · GBThe University of Melbourne · AUBrigham and Women's Hospital · USUniversity of Copenhagen · DKMoffitt Cancer Center · USMemorial Sloan Kettering Cancer Center · USRoswell Park Comprehensive Cancer Center · USMayo Clinic in Florida · USSpanish National Cancer Research Centre · ESCedars-Sinai Medical Center · USDartmouth College · USMayo Clinic in Arizona · USRadboud University Nijmegen · NLUniversitätsklinikum Erlangen · DEUniversity of Hawaiʻi at Mānoa · USUniversity of Helsinki · FI

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
USC/NORRIS COMPREHENSIVE CANCER CENTER (CORE) SUPPORTP30CA014089 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Fumito Ito · 1985 to 2026
$181.4M
XenograftP30CA046592 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI THEODORE S LAWRENCE · 1988 to 2026
$178.2M
Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MATTHEW J TYSKA · 1995 to 2026
$172.8M
Women's Cancer ProgramP30CA015083 · NCI · MAYO CLINIC ROCHESTER · PI Felicity Enders · 1985 to 2026
$151.3M
Two-Spirit Films in Indigenous Cancer HealthP30CA016056 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI MARK G FRATTINI · 1985 to 2026
$116.6M
TRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI KENNETH Lynn WRIGHT · 1998 to 2026
$93.5M
Statistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI TWOROGER, SHELLEY S · 2000 to 2019
$77.8M
Southern Community Cohort StudyR01CA092447 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BLOT, WILLIAM J., ZHENG, WEI · 2001 to 2015
$74.0M
UTAH REGIONAL CANCER CENTERP30CA042014 · NCI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Jared P Rutter · 1986 to 2026
$72.6M
University of Hawaii Cancer Center CCSGP30CA071789 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI Xin Chen · 1996 to 2026
$56.2M
The Role of CHFR in Tumorigenesis and Paclitaxel-Sensitivity in Breast CancerP50CA116201 · NCI · MAYO CLINIC ROCHESTER · PI PETER C LUCAS · 2005 to 2026
$49.9M
Cancer Research UK 10118Cancer Research UK 10119Cancer Research UK 10124Cancer Research UK 14136Cancer Research UK 15007Cancer Research UK 15960Cancer Research UK 16491Cancer Research UK 16561Cancer Research UK 16565Cancer Research UK 19170Cancer Research UK 19187Medical Research Council G0401527Medical Research Council G0501974Medical Research Council G1000143Medical Research Council MC_PC_14105Medical Research Council MR/N003284/1NCI NIH HHS K07 CA095666NCI NIH HHS K07 CA143047NCI NIH HHS K22 CA138563NCI NIH HHS N01 CN025403NCI NIH HHS N01 PC035137NCI NIH HHS N01 PC067010NCI NIH HHS P01 CA017054NCI NIH HHS P01 CA087969NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA014089NCI NIH HHS P30 CA015083NCI NIH HHS P30 CA016056NCI NIH HHS P30 CA042014NCI NIH HHS P30 CA046592NCI NIH HHS P30 CA068485NCI NIH HHS P30 CA071789NCI NIH HHS P30 CA076292NCI NIH HHS P50 CA105009NCI NIH HHS P50 CA116201NCI NIH HHS P50 CA136393NCI NIH HHS P50 CA159981NCI NIH HHS R01 CA049449NCI NIH HHS R01 CA050385NCI NIH HHS R01 CA054419NCI NIH HHS R01 CA056678NCI NIH HHS R01 CA058598NCI NIH HHS R01 CA064277NCI NIH HHS R01 CA065725NCI NIH HHS R01 CA067262NCI NIH HHS R01 CA070867NCI NIH HHS R01 CA072818NCI NIH HHS R01 CA077398NCI NIH HHS R01 CA082664NCI NIH HHS R01 CA092447NCI NIH HHS R01 CA092579NCI NIH HHS R01 CA095023NCI NIH HHS R01 CA100374NCI NIH HHS R01 CA112523NCI NIH HHS R01 CA128813NCI NIH HHS R01 CA128978NCI NIH HHS R01 CA132839NCI NIH HHS R01 CA141298NCI NIH HHS R01 CA148667NCI NIH HHS R01 CA176785NCI NIH HHS RC1 CA145506NCI NIH HHS U01 CA049449NCI NIH HHS U01 CA063464NCI NIH HHS U01 CA067262NCI NIH HHS U01 CA069417NCI NIH HHS U01 CA069467NCI NIH HHS U01 CA069638NCI NIH HHS U01 CA098216NCI NIH HHS U01 CA098233NCI NIH HHS U01 CA098710NCI NIH HHS U01 CA098758NCI NIH HHS U01 CA116167NCI NIH HHS U01 CA122171NCI NIH HHS U01 CA164973NCI NIH HHS U19 CA148065NCI NIH HHS U19 CA148537NCI NIH HHS UM1 CA164920NCI NIH HHS UM1 CA167552NCI NIH HHS UM1 CA176726NCI NIH HHS UM1 CA182910NCI NIH HHS UM1 CA186107NCRR NIH HHS M01 RR000056Wellcome Trust
6 · The paper itself

Abstract

backgroundThe rarity of mutations in PALB2, CHEK2 and ATM make it difficult to estimate precisely associated cancer risks. Population-based family studies have provided evidence that at least some of these mutations are associated with breast cancer risk as high as those associated with rare BRCA2 mutations. We aimed to estimate the relative risks associated with specific rare variants in PALB2, CHEK2 and ATM via a multicentre case-control study.

methodsWe genotyped 10 rare mutations using the custom iCOGS array: PALB2 c.1592delT, c.2816T>G and c.3113G>A, CHEK2 c.349A>G, c.538C>T, c.715G>A, c.1036C>T, c.1312G>T, and c.1343T>G and ATM c.7271T>G. We assessed associations with breast cancer risk (42 671 cases and 42 164 controls), as well as prostate (22 301 cases and 22 320 controls) and ovarian (14 542 cases and 23 491 controls) cancer risk, for each variant.

resultsFor European women, strong evidence of association with breast cancer risk was observed for PALB2 c.1592delT OR 3.44 (95% CI 1.39 to 8.52, p=7.1×10

conclusionsThis report adds to accumulating evidence that at least some variants in these genes are associated with an increased risk of breast cancer that is clinically important.

Indexed as

Genetic Predisposition to DiseaseMutationAtaxia Telangiectasia Mutated ProteinsBreast NeoplasmsCase-Control StudiesCheckpoint Kinase 2Fanconi Anemia Complementation Group N ProteinFemaleGenetic Association StudiesHumansMaleNuclear ProteinsOvarian NeoplasmsProstatic NeoplasmsRiskTumor Suppressor ProteinsAtaxia Telangiectasia Mutated ProteinsATM protein, humanCheckpoint Kinase 2CHEK2 protein, humanFanconi Anemia Complementation Group N ProteinNuclear ProteinsPALB2 protein, humanTumor Suppressor ProteinsCancer: breastCancer: ovarycancer predispositionCancer: prostateGenetics

Identifiers

PMID27595995
PMCPMC5200636
OpenAlexW2476341356

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.