ArticleJournal of clinical laboratory analysis2017
Calculation of LDL-Cholesterol vs. Direct Homogenous Assay.
Article in Journal of clinical laboratory analysis, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Accuracy of 23 Equations for Estimating LDL Cholesterol in a Clinical Laboratory Database of 5,051,467 Patients.Global heart · 2023Pooled it
- Cardioprotective effects of curcumin and piperine against obesity induced oxidative stress in rats.Scientific reports · 2026Article
- Dill extract attenuates liver fibrosis and steatohepatitis in obese ratsResearch in pharmaceutical sciences · 2025Article
- Comparative Evaluation of 24 LDL-C Estimation Equations Against Direct Assays in Two Independent Cohorts.Diagnostics (Basel, Switzerland) · 2025Article
- Refining the Martin-Hopkins method for estimating low-density lipoprotein cholesterol levels: Median versus optimal TG/VLDL-C ratio.PloS one · 2025Article
- Assessing the Practical Differences in LDL-C Estimates Calculated by Friedewald, Martin/Hopkins, or NIH Equation 2: An Observation Cross-Sectional Study.Journal of lipid and atherosclerosis · 2023Article
- Comparison of Methods to Estimate Low-Density Lipoprotein Cholesterol in Patients With High Triglyceride Levels.JAMA network open · 2021Article
- Effect of Ramadan Fasting on Body Composition, Biochemical Profile, and Antioxidant Status in a Sample of Healthy Individuals.International journal of endocrinology and metabolism · 2020Article
- Measuring LDL-cholesterol: what is the best way to do it?Current opinion in cardiology · 2020Review
- A New Equation for Calculation of Low-Density Lipoprotein Cholesterol in Patients With Normolipidemia and/or Hypertriglyceridemia.JAMA cardiology · 2020Article
- Clinical Validation of Eleven Formulas for Calculating LDL-C in Iran.Iranian journal of pathology · 2020Article
- The Triglyceride/HDL Ratio and Triglyceride Glucose Index as Predictors of Glycemic Control in Patients with Diabetes Mellitus Type 2.Medical archives (Sarajevo, Bosnia and Herzegovina) · 2019Article
- Flexibilization of Fasting for Laboratory Determination of the Lipid Profile in Brazil: Science or Convenience?Arquivos brasileiros de cardiologia · 2018Article
- Esterification of HDL-cholesterol is Decreased in Diabetes Mellitus and CAD and Enhanced Following Treatment with Statins.Medical archives (Sarajevo, Bosnia and Herzegovina) · 2018Article
- The Ratio of Unesterified/esterified Cholesterol is the Major Determinant of Atherogenicity of Lipoprotein Fractions.Medical archives (Sarajevo, Bosnia and Herzegovina) · 2018Article
- Stress Attenuation Effect of Combined Approach of Yoga and Diet Intervention Among Metabolic Syndrome Patients.Nigerian medical journal : journal of the Nigeria Medical AssociationArticle
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLow-density lipoprotein cholesterol (LDLc) can be calculated or measured directly and their accordance is the subject of controversy.
objectivesThe aim of this study was to identify the independent predictors of LDLc, to formulate the best equation for calculating LDLc and to evaluate the validity of it and the published formulas, including the new method with adjustable coefficient.
methodsThe profile of serum lipids and (apo)lipoproteins of 310 subjects was used to determine the most accurate formula for calculating serum LDLc. Serum lipids, lipoproteins and apolipoproteins were measured by enzymatic, new homogenous and immunoturbidometric methods, respectively.
resultsMultiple linear regression analysis indicates that total cholesterol, apoB, HDLc and triglyceride are independent predictors of LDLc. We proposed four new formulas to calculate LDLc. As total cholesterol (TC) is the major determinant of LDLc, it can be estimated simply as 0.545 of total cholesterol. Inclusion of HDLc, triglyceride, apoB and a constant value improved the equation slightly. The equation of: LDLc (mg/dl) = 0.75 TC - 0.5 HDLc - 0.1 TG had the lowest mean and SD of difference among all the methods examined here. LDLc was also calculated by the new modified Friedewald's equation using adjustable factor from Martin's table, but it did not improve the results significantly. LDLc gap was correlated significantly and positively with triglyceride and negatively with cholesterol or its subfractions.
conclusionsOur data suggest the simplest formula: LDLc = 0.545 TC or a more detailed: LDLc = 0.75 TC - 0.5 HDLc - 0.1 TG be used for calculating serum LDLc.
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Registered trials
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