Evidence map›Paper›PMID 27595928›Full record

ReviewPharmacology & therapeutics2017

Skeletal and cardiac muscle pericytes: Functions and therapeutic potential.

Iain R Murray, James E Baily, William C W Chen, Ayelet Dar, Zaniah N Gonzalez, Andrew R Jensen, Frank A Petrigliano, Arjun Deb, Neil C Henderson

Abstract readReview
In one paragraph

Review in Pharmacology & therapeutics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed, 1 pooled it
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 1 synthesis or guideline pooled it, 102 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Review
  6. Pannexins in the vasculature.American journal of physiology. Heart and circulatory physiology · 2025
    Review
  7. Article
  8. KMicrovascular research · 2025
    Article
  9. Article
  10. Review
  11. Review
  12. MuSCs and IPCs: roles in skeletal muscle homeostasis, aging and injury.Cellular and molecular life sciences : CMLS · 2024
    Review
  13. Review
  14. Review
  15. Biology of vascular mural cells.Development (Cambridge, England) · 2023
    Review
  16. Engineered exosomes reprogram Gli1Science advances · 2023
    Article
  17. Review
  18. Human Cardiac Pericytes Are Susceptible to SARS-CoV-2 Infection.JACC. Basic to translational science · 2023
    Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 2 countries.

Iain R MurrayBHF Center for Vascular Regeneration and MRC Center for Regenerative Medicine, University of Edinburgh, Edinburgh, UK; Department of Trauma and Orthopaedic Surgery, The University of Edinburgh, Edinburgh, UK.
James E BailyBHF Center for Vascular Regeneration and MRC Center for Regenerative Medicine, University of Edinburgh, Edinburgh, UK.
William C W ChenReseach Laboratory of Electronics and Department of Biological Engineering, Massachusetts Institute of Technology, Boston, MA, USA.
Ayelet DarOrthopedic Hospital Research Center, University of California, Los Angeles, CA, USA.
Zaniah N GonzalezBHF Center for Vascular Regeneration and MRC Center for Regenerative Medicine, University of Edinburgh, Edinburgh, UK.
Andrew R JensenOrthopedic Hospital Research Center, University of California, Los Angeles, CA, USA.
Frank A PetriglianoOrthopedic Hospital Research Center, University of California, Los Angeles, CA, USA.
Arjun DebDivision of Cardiology, Department of Medicine & Molecular Cell and Developmental Biology, and Eli and Edythe Broad Institute of Regenerative Medicine and Stem Cell Research, David Geffen School of Medicine and College of Letters and Sciences, University of California, Los Angeles, CA, USA. Electronic address: adeb@mednet.ucla.edu.
Neil C HendersonMRC Centre for Inflammation Research, University of Edinburgh, Edinburgh, UK. Electronic address: Neil.Henderson@ed.ac.uk.
MRC Centre for Regenerative Medicine · GBUniversity of California, Los Angeles · USUniversity of Edinburgh · GBBroad Center · USMassachusetts Institute of Technology · USOrthopaedic Hospital · US

Funding

Role of ABCC6 in cardivascular calcificationR01HL137241 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DEB, ARJUN · 2017 to 2020
$2.1M
Role of Wnts in Cardiac RepairR01HL102190 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DEB, ARJUN · 2010 to 2014
$1.8M
Role of mesenchymal-endothelial-transition in cardiac hypertrophyR01HL129178 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DEB, ARJUN · 2015 to 2018
$1.5M
Medical Research Council G0901697NHLBI NIH HHS R01 HL102190NHLBI NIH HHS R01 HL129178NHLBI NIH HHS R01 HL137241Wellcome TrustWellcome Trust 097483Wellcome Trust 103749
6 · The paper itself

Abstract

Pericytes are periendothelial mesenchymal cells residing within the microvasculature. Skeletal muscle and cardiac pericytes are now recognized to fulfill an increasing number of functions in normal tissue homeostasis, including contributing to microvascular function by maintaining vessel stability and regulating capillary flow. In the setting of muscle injury, pericytes contribute to a regenerative microenvironment through release of trophic factors and by modulating local immune responses. In skeletal muscle, pericytes also directly enhance tissue healing by differentiating into myofibers. Conversely, pericytes have also been implicated in the development of disease states, including fibrosis, heterotopic ossication and calcification, atherosclerosis, and tumor angiogenesis. Despite increased recognition of pericyte heterogeneity, it is not yet clear whether specific subsets of pericytes are responsible for individual functions in skeletal and cardiac muscle homeostasis and disease.

Indexed as

AnimalsHomeostasisHumansMicrovesselsMuscle, SkeletalMyocardiumNeoplasmsNeovascularization, PathologicPericytesRegenerationHeartMesenchymal stem cellMSCMusclePerivascular stem cellPSC

Identifiers

PMID27595928
PMCPMC5726267
OpenAlexW2511748497

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.