Evidence map›Paper›PMID 27595916›Full record

ArticleProstate cancer and prostatic diseases2017

Saturated fat intake and prostate cancer aggressiveness: results from the population-based North Carolina-Louisiana Prostate Cancer Project.

E H Allott, L Arab, L J Su, L Farnan, E T H Fontham, J L Mohler, J T Bensen, S E Steck

Open access · greenAbstract read
PubMed Publisher
In one paragraph

Article in Prostate cancer and prostatic diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Prostate Cancer and the Mevalonate Pathway.International journal of molecular sciences · 2024
    Review
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Targeting lipid metabolism in metastatic prostate cancer.Therapeutic advances in medical oncology · 2023
    Review
  10. Article
  11. Review
  12. Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

E H AllottDepartment of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
L ArabDavid Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
L J SuWinthrop P Rockefeller Cancer Institute and College of Public Health, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
L FarnanLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
E T H FonthamSchool of Public Health, Louisiana State University Health Sciences Center, New Orleans, LA, USA.
J L MohlerLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
J T BensenDepartment of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
S E SteckDepartment of Epidemiology and Biostatistics, University of South Carolina, Columbia, SC, USA.
University of North Carolina at Chapel Hill · USLouisiana State University Health Sciences Center New Orleans · USUniversity of California, Los Angeles · USUniversity of South Carolina · USWinthrop Rockefeller Foundation · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEpidemiologic and laboratory evidence supports a role for cholesterol in prostate cancer (PC). Dietary saturated fat content impacts serum cholesterol levels. However, epidemiologic associations between saturated fat and PC aggressiveness are inconsistent. We hypothesized that high saturated fat intake would be associated with increased PC aggressiveness, and that statin use would modify this association.

methodsOf 1854 PC cases in the North Carolina-Louisiana PC Project, 321 (17%) were classified as high aggressive (Gleason sum ⩾8, PSA>20 ng ml

resultsHigh total fat-adjusted saturated fat intake was associated with an elevated odds ratio (OR) for aggressive PC (OR

conclusionsHigh total fat-adjusted saturated fat intake was associated with increased PC aggressiveness, with a suggestion of a stronger effect in men not using statins. The association between total fat-adjusted cholesterol intake and PC aggressiveness was most pronounced in European Americans.

Indexed as

Dietary FatsFatty AcidsFeeding BehaviorAdultAgedBiomarkers, TumorDisease ProgressionHumansLouisianaMaleMiddle AgedNeoplasm GradingNeoplasm StagingNorth CarolinaOdds RatioPopulation SurveillanceBiomarkers, TumorDietary FatsFatty Acids

Identifiers

PMID27595916
OpenAlexW2517867511

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.