ArticleScientific reports2016
High protein flexibility and reduced hydration water dynamics are key pressure adaptive strategies in prokaryotes.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 59 citations in OpenAlex.
- Quasi-elastic neutron scattering studies on bacterial spores and their hydration water.Scientific reports · 2026Article
- Regulation of gene expression under high hydrostatic pressure: the versatile role of the master regulator SurR in energy metabolism.Frontiers in microbiology · 2025Article
- Biological functions at high pressure: transcriptome response ofFrontiers in microbiology · 2024Article
- Anisotropic dynamics of an interfacial enzyme active site observed using tethered substrate analogs and ultrafast 2D IR spectroscopy.The Journal of chemical physics · 2023Article
- Exploring the Limits of Biological Complexity Amenable to Studies by Incoherent Neutron Spectroscopy.Life (Basel, Switzerland) · 2022Review
- Unravelling the Adaptation Mechanisms to High Pressure in Proteins.International journal of molecular sciences · 2022Article
- Characterizing the Piezosphere: The Effects of Decompression on Microbial Growth Dynamics.Frontiers in microbiology · 2022Article
- Experimental study of proteome halophilicity using nanoDSF: a proof of concept.Extremophiles : life under extreme conditions · 2021Article
- Genomes of Thaumarchaeota from deep sea sediments reveal specific adaptations of three independently evolved lineages.The ISME journal · 2021Article
- The Piezo-Hyperthermophilic ArchaeonFrontiers in microbiology · 2021Article
- The molecular dynamics of bacterial spore and the role of calcium dipicolinate in core properties at the sub-nanosecond time-scale.Scientific reports · 2020Article
- Brain lateralization probed by water diffusion at the atomic to micrometric scale.Scientific reports · 2019Article
- Temperature dependence of nanoscale dynamic processes measured in living millipedes by high resolution inelastic and elastic neutron scattering.Scientific reports · 2019Article
- Dynamics Properties of Photosynthetic Microorganisms Probed by Incoherent Neutron Scattering.Biophysical journal · 2019Article
- Dynamics of a family of cyan fluorescent proteins probed by incoherent neutron scattering.Journal of the Royal Society, Interface · 2019Article
- High Hydrostatic Pressure Induces a Lipid Phase Transition and Molecular Rearrangements in Low-Density Lipoprotein Nanoparticles.Particle & particle systems characterization : measurement and description of particle properties and behavior in powders and other disperse systems · 2018Article
- Microscopic diffusion processes measured in living planarians.Scientific reports · 2018Article
- The effects of pressure on the energy landscape of proteins.Scientific reports · 2018Article
- High hydrostatic pressure specifically affects molecular dynamics and shape of low-density lipoprotein particles.Scientific reports · 2017Article
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Water and protein dynamics on a nanometer scale were measured by quasi-elastic neutron scattering in the piezophile archaeon Thermococcus barophilus and the closely related pressure-sensitive Thermococcus kodakarensis, at 0.1 and 40 MPa. We show that cells of the pressure sensitive organism exhibit higher intrinsic stability. Both the hydration water dynamics and the fast protein and lipid dynamics are reduced under pressure. In contrast, the proteome of T. barophilus is more pressure sensitive than that of T. kodakarensis. The diffusion coefficient of hydration water is reduced, while the fast protein and lipid dynamics are slightly enhanced with increasing pressure. These findings show that the coupling between hydration water and cellular constituents might not be simply a master-slave relationship. We propose that the high flexibility of the T. barophilus proteome associated with reduced hydration water may be the keys to the molecular adaptation of the cells to high hydrostatic pressure.
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