ArticleRedox report : communications in free radical research2017
The diaphragm is better protected from oxidative stress than hindlimb skeletal muscle during CLP-induced sepsis.
Article in Redox report : communications in free radical research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 14 citations in OpenAlex.
- Prolonged sepsis triggers abnormal mitochondrial dynamics in the limb muscles and diaphragm.Molecular and cellular biochemistry · 2025Article
- Effects ofCurrent issues in molecular biology · 2024Article
- Probiotic Potential of the Marine IsolateMarine drugs · 2023Article
- Article
- Voluntary wheel exercise training affects locomotor muscle, but not the diaphragm in the rat.Frontiers in physiology · 2022Article
- Sepsis Disrupts Mitochondrial Function and Diaphragm Morphology.Frontiers in physiology · 2021Article
- Assessment of inflammatory markers and mitochondrial factors in a rat model of sepsis-induced myocardial dysfunction.American journal of translational research · 2020Article
- Differential regulation of myofibrillar proteins in skeletal muscles of septic mice.Physiological reports · 2019Article
- Mitochondrial respiration and HAmerican journal of physiology. Cell physiology · 2019Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe aim of this study was to determine whether non-lethal sepsis induced by cecal ligation and puncture (CLP) modulates oxidative damage and enzymatic antioxidant defenses in diaphragm and hindlimb skeletal muscles (soleus and Extensor Digitorus Longus (EDL)).
methodsFemale Wistar rats were divided into four experimental groups: (1) control animals, (2) animals sacrificed 2 hours or (3) 7 days after CLP, and (4) sham-operated animals. At the end of the experimental procedure, EDL, soleus, and diaphragm muscles were harvested and 4-hydroxynonenal (HNE)-protein adducts and protein carbonyl contents were examined in relation to superoxide dismutase and catalase expression and activities.
resultsWe observed that both non-respiratory oxidative (i.e. soleus) and glycolytic skeletal muscles (i.e. EDL) are more susceptible to sepsis-induced oxidative stress than diaphragm, as attested by an increase in 4-HNE protein adducts and carbonylated proteins after 2 hours of CLP only in soleus and EDL. DISCUSSION: These differences could be explained by higher basal enzymatic antioxidant activities in diaphragm compared to hindlimb skeletal muscles. Together, these results demonstrate that diaphragm is better protected from oxidative stress than hindlimb skeletal muscles during CLP-induced sepsis.
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