ArticleJournal of clinical laboratory analysis2017
Harmonization Study Between LC-MS/MS and Diasorin RIA for Measurement of 25-Hydroxyvitamin D Concentrations in a Large Population Survey.
Article in Journal of clinical laboratory analysis, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review and meta-analysis of the response of serum 25-hydroxyvitamin D concentration to vitamin D supplementation from RCTs from around the globe.European journal of clinical nutrition · 2019Pooled it
- Upward changes in serum 25-hydroxyvitamin D levels in South Korea: the Korea National Health and Nutrition Examination Survey studies IX (2022-2023) versus VI (2013-2014).Osteoporosis and sarcopenia · 2026Article
- The association between serum vitamin D status and dental caries or molar incisor hypomineralisation in 7-9-year-old Norwegian children: a cross-sectional study.BMC public health · 2024Article
- Determination of vitamin D status in singleton and twin gestations using CLIA and LC-MS/MS.Endocrine connections · 2023Article
- Vitamin D Status in Women with a History of Infertility and Decreased Fecundability: A Population-Based Study.Nutrients · 2023Article
- Vitamin D levels and COVID 19 risk and death; is there an association?Nutrition journal · 2022Article
- Why do so many trials of vitamin D supplementation fail?Endocrine connections · 2020Review
- Could vitamin D reduce obesity-associated inflammation? Observational and Mendelian randomization study.The American journal of clinical nutrition · 2020Observational
- Vitamin D testing: advantages and limits of the current assays.European journal of clinical nutrition · 2020Review
- Analytical Bias in the Measurement of Plasma 25-Hydroxyvitamin D Concentrations in Infants.International journal of environmental research and public health · 2020Article
- Article
- Re: Scragg-Emerging Evidence of Thresholds for Beneficial Effects from Vitamin D Supplementation.Nutrients · 2019Article
- Limitations of platform assays to measure serum 25OHD level impact on guidelines and practice decision making.Metabolism: clinical and experimental · 2018Article
- Article
- Vitamin D supplementation trials: Navigating the maze of unpredictable results.Perspectives in clinical researchReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundPopulation-based research on vitamin D has increased dramatically in recent years. Such studies are typically reliant on assay procedures to measure reliable and comparable levels of 25-hydroxyvitamin D [25(OH)D] concentrations.
methodsConcentrations of 25(OH)D
resultsConcentrations measured by LC-MS/MS were much higher than those measured by Diasorin RIA, with a mean difference of 12.9 ng/ml. Constant variation was evident between batch measurements after log transformation. Statistical formula was applied separately for each batch of LC-MS/MS measurements, enabling us to remove both the constant and proportional bias that was evident prior to the transformation.
conclusionDespite the introduction of schemes/programs to improve accuracy of assays to measure 25(OH)D, significant differences can still happen. In these instances, methods to harmonize measurements based on a relatively small number of replicates can be successfully applied to establish confidence and to enable between-study comparisons.
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Registered trials
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