ArticleBMC genomics2016
Culture-independent genomic characterisation of Candidatus Chlamydia sanzinia, a novel uncultivated bacterium infecting snakes.
Article in BMC genomics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 76 citations in OpenAlex.
- Molecular Survey of Chlamydial Infections in Three Public Bird Collections in Tehran, Iran.Veterinary medicine and science · 2025Article
- Identifying Infectious Agents in Snakes (Boidae and Pythonidae) with and Without Respiratory Disease.Animals : an open access journal from MDPI · 2025Article
- Chlamydiosis in Animals.Animals : an open access journal from MDPI · 2024Review
- Seroprevalence and Risk Factors ofVector borne and zoonotic diseases (Larchmont, N.Y.) · 2024Article
- New insight on chlamydiae.Journal of veterinary research · 2023Article
- Use of gene sequences as type for naming prokaryotes: Recommendations of the international committee on the taxonomy of chlamydiae.New microbes and new infections · 2023Article
- Whole Genome Sequencing and Comparative Genomic Analysis ofPathogens (Basel, Switzerland) · 2023Article
- An in silico analysis of rpoB mutations to affect Chlamydia trachomatis sensitivity to rifamycin.Journal, genetic engineering & biotechnology · 2022Article
- Occurrence of Chlamydiae in Corvids in Northeast Italy.Animals : an open access journal from MDPI · 2022Article
- Detection of a Novel Chlamydia Species in Invasive Turtles.Animals : an open access journal from MDPI · 2022Article
- Detection of Chlamydial DNA from Mediterranean Loggerhead Sea Turtles in Southern Italy.Animals : an open access journal from MDPI · 2022Article
- Whole Genome Sequencing and Comparative Genome Analyses ofPathogens (Basel, Switzerland) · 2021Article
- Seroprevalence of Chlamydia abortus infection in yak (Bos grunniens) in Tibet, China.Irish veterinary journal · 2021Article
- Pangenomics reveals alternative environmental lifestyles among chlamydiae.Nature communications · 2021Article
- Draft Genome Sequences of Avian Chlamydia abortus Genotype G2 Strain 15-49d3, Isolated from Mallard, and Genotype 1V Strain 15-58d44, Isolated from Magpie in Poland.Microbiology resource announcements · 2021Article
- Whole genome de novo sequencing and comparative genomic analyses suggests that Chlamydia psittaci strain 84/2334 should be reclassified as Chlamydia abortus species.BMC genomics · 2021Article
- Article
- Chlamydiae - What's New?Journal of veterinary research · 2020Article
- Chronic wasting associated with Chlamydia pneumoniae in three ex situ breeding facilities for tropical frogs.Antonie van Leeuwenhoek · 2020Article
- Chlamydia pan-genomic analysis reveals balance between host adaptation and selective pressure to genome reduction.BMC genomics · 2019Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecent molecular studies have revealed considerably more diversity in the phylum Chlamydiae than was previously thought. Evidence is growing that many of these novel chlamydiae may be important pathogens in humans and animals. A significant barrier to characterising these novel chlamydiae is the requirement for culturing. We recently identified a range of novel uncultured chlamydiae in captive snakes in Switzerland, however, nothing is known about their biology. Using a metagenomics approach, the aim of this study was to characterise the genome of a novel chlamydial taxon from the choana of a captive snake. In doing so, we propose a new candidate species in the genus Chlamydia (Candidatus Chlamydia sanzinia) and reveal new information about the biological diversity of this important group of pathogens.
resultsWe identified two chlamydial genomic contigs: a 1,113,073 bp contig, and a 7,504 bp contig, representing the chromosome and plasmid of Ca. Chlamydia sanzinia strain 2742-308, respectively. The 998 predicted coding regions include an expanded repertoire of outer membrane proteins (Pmps and Omps), some of which exhibited frameshift mutations, as well as several chlamydial virulence factors such as the translocating actin-recruitment phosphoprotein (Tarp) and macrophage inhibition potentiator (Mip). A suite of putative inclusion membrane proteins were also predicted. Notably, no evidence of a traditional chlamydial plasticity zone was identified. Phylogenetically, Ca. Chlamydia sanzinia forms a clade with C. pneumoniae and C. pecorum, distinct from former "Chlamydophila" species.
conclusionsGenomic characterisation of a novel uncultured chlamydiae from the first reptilian host has expanded our understanding of the diversity and biology of a genus that was thought to be the most well-characterised in this unique phylum. It is anticipated that this method will be suitable for characterisation of other novel chlamydiae.
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