ArticleNature chemical biology2016
Small-molecule WNK inhibition regulates cardiovascular and renal function.
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Article in Nature chemical biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers.
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92citing papers in PubMed
6.6field-weighted citation impact, top 3% of its field
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Who cites it
92 citing papers in PubMed, 164 citations in OpenAlex.
- No lysine? No problem: the surprising roles of WNK kinases in physiology and disease.The Biochemical journal · 2026Review
- WNK1 links ionic signals to microtubule dynamics to control pyrin inflammasome assembly.Science advances · 2026Article
- WNK1 Phosphorylation Sites in TBC1D1 and TBC1D4 Modulate Cell-Surface Abundance of GLUT1.Cells · 2026Article
- Identification and Validation of a Novel WNK2 Inhibitor: A New Genetically Informed Target for Osteoarthritis Drug Development.ACS omega · 2026Article
- Drugging non-canonical kinases in cancer therapeutics: Molecular targets, underlying mechanisms and small-molecule inhibitors.Acta pharmaceutica Sinica. B · 2026Review
- Targeting WNK1 Releases Differentiation Block in Acute Myeloid Leukemia.bioRxiv : the preprint server for biology · 2026Article
- The WNK-OXSR1 osmosensing pathway mediates intestinal regeneration via Hippo-YAP signaling.The EMBO journal · 2026Article
- Enhancing KCC2 function reduces interictal activity and prevents seizures in temporal lobe epilepsy.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- LRRC8A-containing anion channels promote glioblastoma proliferation via a WNK1/mTORC2-dependent mechanism.The Journal of physiology · 2026Article
- Knock-down of the long isoform of the WNK1 kinase mitigates the anti-glomerular basement membrane glomerulonephritis in mice.Scientific reports · 2026Article
- The Story of Aldosterone Escape.Journal of the American Society of Nephrology : JASN · 2026Review
- WNK1 promotes head and neck squamous cell carcinoma progression through activation of NF-κB signaling pathway.Discover oncology · 2025Article
- Connexin 43 drives glioblastoma cancer stem cell phenotypes through a WNK lysine-deficient protein kinase 1-c-MYC signaling axis.Cell reports · 2025Article
- WNKs regulate mouse behavior and alter central nervous system glucose uptake and insulin signaling.bioRxiv : the preprint server for biology · 2025Article
- Article
- NRBP1 pseudokinase binds to and activates the WNK pathway in response to osmotic stress.Science advances · 2025Article
- Article
- WNK1 mediates M-CSF-induced macropinocytosis to enforce macrophage lineage fidelity.Nature communications · 2025Article
- WNK1 signalling regulates amino acid transport and mTORC1 activity to sustain acute myeloid leukaemia growth.Nature communications · 2025Article
- Oxidative Stress-Responsive 1 Kinase Catalytic Activity Promotes Triple Negative Breast Cancer Oncogenic Potential.ACS pharmacology & translational science · 2025Article
32 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
61 authors at 1 institution in 1 country.
Ken YamadaNovartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA.
Hyi-Man ParkNovartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA.
Dean F RigelNovartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA.
Keith DiPetrilloNovartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA.
Erin J WhalenNovartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA.
Anthony AnisowiczNovartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA.
Michael BeilNovartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA.
James BerstlerNovartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA.
Cara Emily BrocklehurstNovartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA.
Debra A BurdickNovartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA.
Shari L CaplanNovartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA.
Michael P CapparelliNovartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA.
Guanjing ChenNovartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA.
Wei ChenNovartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA.
Bethany DaleNovartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA.
Lin DengNovartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA.
Fumin FuNovartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA.
Norio HamamatsuNovartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA.
Kouki HarasakiNovartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA.
Tracey HerrNovartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA.
Peter HoffmannNovartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA.
Qi-Ying HuNovartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA.
Waan-Jeng HuangNovartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA.
Neeraja IdamakantiNovartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA.
Hidetomo ImaseNovartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA.
Yuki IwakiNovartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA.
Monish JainNovartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA.
Jey JeyaseelanNovartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA.
Mitsunori KatoNovartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA.
Virendar K KaushikNovartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA.
Darcy KohlsNovartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA.
Vidya KunjathoorNovartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA.
Daniel LaSalaNovartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA.
Jongchan LeeNovartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA.
Jing LiuNovartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA.
Yang LuoNovartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA.
Fupeng MaNovartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA.
Ruowei MoNovartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA.
Sarah MowbrayNovartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA.
Muneto MogiNovartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA.
Flavio OssolaNovartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA.
Pramod PandeyNovartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA.
Sejal J PatelNovartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA.
Swetha RaghavanNovartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA.
Bahaa SalemNovartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA.
Yuka H ShanadoNovartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA.
Gary M TrakshelNovartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA.
Gordon TurnerNovartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA.
Hiromichi WakaiNovartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA.
Chunhua WangNovartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA.
Stephen WeldonNovartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA.
Jennifer B WielickiNovartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA.
Xiaoling XieNovartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA.
Lingfei XuNovartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA.
Yukiko I YagiNovartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA.
Kayo YasoshimaNovartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA.
Jianning YinNovartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA.
David YoweNovartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA.
Ji-Hu ZhangNovartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA.
Gang ZhengNovartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA.
Lauren MonovichNovartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA.
Novartis (United States) · US
Funding
No grant is acknowledged in the PubMed record.
Abstract
The With-No-Lysine (K) (WNK) kinases play a critical role in blood pressure regulation and body fluid and electrolyte homeostasis. Herein, we introduce the first orally bioavailable pan-WNK-kinase inhibitor, WNK463, that exploits unique structural features of the WNK kinases for both affinity and kinase selectivity. In rodent models of hypertension, WNK463 affects blood pressure and body fluid and electro-lyte homeostasis, consistent with WNK-kinase-associated physiology and pathophysiology.
Indexed as
AnimalsCardiovascular SystemHumansImidazolesKidneyKidney Function TestsMiceMice, Inbred C57BLMice, TransgenicProtein Kinase InhibitorsProtein Serine-Threonine KinasesPyrrolidinesRatsRats, Sprague-DawleySmall Molecule LibrariesImidazolesProtein Kinase InhibitorsProtein Serine-Threonine KinasesPyrrolidinesSmall Molecule LibrariesWNK463
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.