ArticleBioMed research international2016
Cytotoxicity and Initial Biocompatibility of Endodontic Biomaterials (MTA and Biodentine™) Used as Root-End Filling Materials.
Article in BioMed research international, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- Histopathological and immunohistochemical characterization of pulp tissue reaction to ACTIVA BioACTIVE base/liner in primary teeth pulpotomy: a randomized clinical trial.BMC oral health · 2025Trial
- Comparative evaluation of pushout bond strength of three different sealers: AnJournal of conservative dentistry and endodontics · 2025Article
- A Critical Review of the Role of Geristore® in Contemporary Endodontics.Iranian endodontic journal · 2025Review
- The Effect of Chitosan Incorporation on Physico-Mechanical and Biological Characteristics of a Calcium Silicate Filling Material.Dentistry journal · 2024Article
- The Effects of Tricalcium-Silicate-Nanoparticle-Containing Cement: In Vitro and In Vivo Studies.Materials (Basel, Switzerland) · 2023Article
- Real-time evaluation of the biocompatibility of calcium silicate-based endodontic cements: An in vitro study.Clinical and experimental dental research · 2023Article
- Biodentine Inhibits the Initial Microbial Adhesion of Oral Microbiota In Vivo.Antibiotics (Basel, Switzerland) · 2022Article
- Effect of biodentine coated with emdogain on proliferation and differentiation of human stem cells from the apical papilla.Molecular biology reports · 2022Article
- Calcium silicate-based cements cause environmental stiffness and show diverse potential to induce osteogenesis in human osteoblastic cells.Scientific reports · 2021Article
- Review
- Human dental pulp stem cell responses to different dental pulp capping materials.BMC oral health · 2021Article
- Biomineralization of three calcium silicate-based cements after implantation in rat subcutaneous tissue.Restorative dentistry & endodontics · 2021Article
- The calcium dynamics of human dental pulp stem cells stimulated with tricalcium silicate-based cements determine their differentiation and mineralization outcome.Scientific reports · 2021Article
- Biocompatibility of Mineral Trioxide Aggregate Mixed with Different Accelerators: an Animal Study.Journal of dentistry (Shiraz, Iran) · 2020Article
- Biocompatibility of Biodentine™Dentistry journal · 2020Article
- Bioactivity of Bioceramic Materials Used in the Dentin-Pulp Complex Therapy: A Systematic Review.Materials (Basel, Switzerland) · 2019Review
- Cytotoxicity Evaluation of Endodontic Pins on L929 Cell Line.BioMed research international · 2019Article
- The use of Bioceramics as root-end filling materials in periradicular surgery: A literature review.The Saudi dental journal · 2018Review
- Molecular insight to size and dose-dependent cellular toxicity exhibited by a green synthesized bioceramic nanohybrid with macrophages for dental applications.Toxicology research · 2018Article
- Effect of root canal sealers on human periodontal ligament fibroblast viability: ex vivo study.Odontology · 2018Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective. The aim of this study was to evaluate the cytotoxicity and cellular adhesion of Mineral Trioxide Aggregate (MTA) and Biodentine (BD) on periodontal ligament fibroblasts (PDL). Methods. PDL cells were obtained from nonerupted third molars and cultured; MTS cellular profusion test was carried out in two groups: MTA and BD, with respective controls at different time periods. Also, the LIVE/DEAD assay was performed at 24 h. For evaluation of cellular adhesion, immunocytochemistry was conducted to discern the expression of Integrin β1 and Vinculin at 12 h and 24 h. Statistical analysis was performed by the Kruskal-Wallis and Mann-Whitney U tests. Results. MTA and BD exhibited living cells up to 7 days. More expressions of Integrin β1 and Vinculin were demonstrated in the control group, followed by BD and MTA, which also showed cellular loss and morphological changes. There was a significant difference in the experimental groups cultured for 5 and 7 days compared with the control, but there was no significant statistical difference between both cements. Conclusions. Neither material was cytotoxic during the time evaluated. There was an increase of cell adhesion through the expression of focal contacts observed in the case of BD, followed by MTA, but not significantly.
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