ArticleJournal of the Korean Association of Oral and Maxillofacial Surgeons2016
Evaluation of the predisposing factors and involved outcome of surgical treatment in bisphosphonate-related osteonecrosis of the jaw cases including bone biopsies.
Article in Journal of the Korean Association of Oral and Maxillofacial Surgeons, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prognostic indicators in medication-related osteonecrosis of the jaw: A systematic review and meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025Pooled it
- Pentoxifylline and Tocopherol for the Management of Medication-Related Osteonecrosis of the Jaw (MRONJ): A Retrospective Clinical Audit.Antibiotics (Basel, Switzerland) · 2026Article
- Application of navigation system during surgery for medication-related osteonecrosis of the jaw.Journal of the Korean Association of Oral and Maxillofacial Surgeons · 2025Article
- Magnesium Nanocomposite Hydrogel Reverses the Pathologies to Enhance Mandible Regeneration.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Prediction of wound healing status following dental extraction using Adapted-University of Connecticut osteonecrosis numerical scale: A retrospective study.Health science reports · 2024Article
- Clinical significance of drug cessation on medication-related osteonecrosis of the jaw in patients with osteoporosis.Journal of the Korean Association of Oral and Maxillofacial Surgeons · 2023Article
- Comparison of the Effect of Oral Versus Intravenous Bisphosphonate Administration on Osteoclastogenesis in Advanced-Stage Medication-Related Osteonecrosis of the Jaw Patients.Journal of clinical medicine · 2021Article
- Treatment outcomes and prognostic factors of medication-related osteonecrosis of the jaw: a case- and literature-based review.Clinical oral investigations · 2019Review
- Risk factors of medication-related osteonecrosis of the jaw: a retrospective study in a Turkish subpopulation.Journal of the Korean Association of Oral and Maxillofacial Surgeons · 2019Article
- Clinical profile of individuals with bisphosphonate-related osteonecrosis of the jaw: an integrative review.Sao Paulo medical journal = Revista paulista de medicinaReview
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThis study examined the statistical relevance of whether the systemic predisposing factors affect the prognosis of surgical treatment of bisphosphonate-related osteonecrosis of the jaw (BRONJ). All cases had undergone bone biopsies to determine the characteristics of the mechanisms of BRONJ by optical microscopy. MATERIALS AND
methodsThe data included 54 BRONJ cases who underwent surgery and in whom bone biopsies were performed. The results of surgery were evaluated and the results were classified into 3 categories: normal recovery, delayed recovery, and recurrence after surgery. The medical history, such as diabetes mellitus, medication of steroids, malignancies on other sites was investigated for an evaluation of the systemic predisposing factors in relation to the prognosis. The three factors involved with the medication of bisphosphonate (BP) were the medication route, medication period, and drug holiday of BP before surgery. The serum C-terminal cross-linking telopeptide (CTX) value and presence of microorganism colony in bone biopsy specimens were also checked. Statistical analysis was then carried out to determine the relationship between these factors and the results of surgery.
resultsThe group of patients suffering from diabetes and on steroids tended to show poorer results after surgery. Parenteral medication of BP made the patients have a poorer prognosis after surgery than oral medication. In contrast, the medication period and drug holiday of BP before surgery did not have significance with the results of surgery nor did the serum CTX value and presence of microorganism colony. Necrotic bone specimens in this study typically showed disappearing new bone formation around the osteocytic lacunae and destroyed Howship's lacunae.
conclusionAlthough many variables exist, this study could in part, predict the prognosis of surgical treatment of BRONJ by taking the patient's medical history.
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