ArticleCase reports in transplantation2016
High on Cannabis and Calcineurin Inhibitors: A Word of Warning in an Era of Legalized Marijuana.
Article in Case reports in transplantation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Systematic review of drug-drug interactions of delta-9-tetrahydrocannabinol, cannabidiol, andFrontiers in pharmacology · 2024Pooled it
- An Overview of the Potential for Pharmacokinetic Interactions Between Drugs and Cannabis Products in Humans.Pharmaceutics · 2025Review
- Human Data on Pharmacokinetic Interactions of Cannabinoids: A Narrative Review.Current pharmaceutical design · 2024Review
- Cannabis Use and Heart Transplantation: Disparities and Opportunities to Improve Outcomes.Circulation. Heart failure · 2022Review
- Therapeutic Cannabis Use in Kidney Disease: A Survey of Canadian Nephrologists.Kidney medicine · 2022Article
- Clinical Relevance of Drug Interactions with Cannabis: A Systematic Review.Journal of clinical medicine · 2022Review
- Late presentation of posterior reversible encephalopathy syndrome following liver transplantation in the setting of tacrolimus and cannabis use.Canadian liver journal · 2022Article
- Cardiac Transplantation and the Use of Cannabis.Life (Basel, Switzerland) · 2021Review
- The growing dilemma of legalized cannabis and heart transplantation.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2021Review
- Delta-9-Tetrahydrocannabinol and Cannabidiol Drug-Drug Interactions.Medical cannabis and cannabinoids · 2020Review
- The nephrologist's guide to cannabis and cannabinoids.Current opinion in nephrology and hypertension · 2020Review
- Cannabis abuse and dependence in kidney transplant candidates.Journal of psychosomatic research · 2019Article
- Cannabis and the liver: Things you wanted to know but were afraid to ask.Canadian liver journal · 2019Review
- History of Marijuana Use Does Not Affect Outcomes on the Liver Transplant Waitlist.Transplantation · 2018Article
- Corrigendum to "High on Cannabis and Calcineurin Inhibitors: A Word of Warning in an Era of Legalized Marijuana".Case reports in transplantation · 2018Article
- Article
- Marijuana Use and Organ Transplantation: a Review and Implications for Clinical Practice.Current psychiatry reports · 2017Review
- Review
Corrections and comments
- Erratum issued
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tacrolimus, a potent immunosuppressant medication, acts by inhibiting calcineurin, which eventually leads to inhibition of T-cell activation. The drug is commonly used to prevent graft rejection in solid organ transplant and graft-versus-host disease in hematopoietic stem cell transplant patients. Tacrolimus has a narrow therapeutic index with variable oral bioavailability and metabolism via cytochrome P-450 3A enzyme. Toxicity can occur from overdosing or from drug-drug interactions with the simultaneous administration of cytochrome P-450 3A inhibitors and possibly P-glycoprotein inhibitors. Tacrolimus toxicity can be severe and may include multiorgan damage. We present a case of suspected tacrolimus toxicity in a postallogeneic hematopoietic stem cell transplant patient who was concurrently using oral marijuana. This case represents an important and growing clinical scenario with the increasing legalization and use of marijuana throughout the United States.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.