Evidence map›Paper›PMID 27595012›Full record

ArticlePolymers

PEG-chitosan hydrogel with tunable stiffness for study of drug response of breast cancer cells.

Fei-Chien Chang, Ching-Ting Tsao, Anqi Lin, Mengying Zhang, Sheeny Lan Levengood, Miqin Zhang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Polymers. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.9field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 51 citations in OpenAlex.

  1. Multi-armed star-shaped PEGMikrochimica acta · 2026
    Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. Review
  11. 3D Cell Culture Systems: Tumor Application, Advantages, and Disadvantages.International journal of molecular sciences · 2021
    Review
  12. Chitosan as an Underrated Polymer in Modern Tissue Engineering.Nanomaterials (Basel, Switzerland) · 2021
    Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Engineering Approaches to Study Cellular Decision Making.Annual review of biomedical engineering · 2018
    Review
  20. Biomechanical forces in tissue engineered tumor models.Current opinion in biomedical engineering · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Fei-Chien ChangDepartment of Materials Science and Engineering, University of Washington, Seattle, Washington 98195, USA.
Ching-Ting TsaoDepartment of Materials Science and Engineering, University of Washington, Seattle, Washington 98195, USA.
Anqi LinDepartment of Materials Science and Engineering, University of Washington, Seattle, Washington 98195, USA.
Mengying ZhangDepartment of Molecular Engineering and Science Institute, University of Washington, Seattle, Washington 98195, USA.
Sheeny Lan LevengoodDepartment of Materials Science and Engineering, University of Washington, Seattle, Washington 98195, USA.
Miqin ZhangDepartment of Materials Science and Engineering, University of Washington, Seattle, Washington 98195, USA.
University of Washington · US

Funding

Nanotechnology and Physical Science Training Program in Cancer ResearchT32CA138312 · NCI · UNIVERSITY OF WASHINGTON · PI ZHANG, MIQIN · 2009 to 2013
$1.5M
New 3D tumor models to rapidly test drugs for brain cancer therapyR01CA172455 · NCI · UNIVERSITY OF WASHINGTON · PI ZHANG, MIQIN · 2013 to 2016
$1.1M
NCI NIH HHS R01 CA172455NCI NIH HHS T32 CA138312
6 · The paper itself

Abstract

Mechanical properties of the extracellular matrix have a profound effect on the behavior of anchorage-dependent cells. However, the mechanisms that define the effects of matrix stiffness on cell behavior remains unclear. Therefore, the development and fabrication of synthetic matrices with well-defined stiffness is invaluable for studying the interactions of cells with their biophysical microenvironment

Indexed as

chitosanextracellular matrixhydrogelmodulusstiffnesstunable

Identifiers

PMID27595012
PMCPMC5004991
OpenAlexW2306419042

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.