ArticleForensic toxicology
Chiral enantioresolution of cathinone derivatives present in "legal highs", and enantioselectivity evaluation on cytotoxicity of 3,4-methylenedioxypyrovalerone (MDPV).
Article in Forensic toxicology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Isolation, Characterization, and Stability Assessment of Pure Enantiomers of Cathinone Derivatives via Semi-Preparative HPLC-UV Using a Phenomenex LuxMolecules (Basel, Switzerland) · 2026Article
- Preparative Chiral Resolution of Synthetic Cathinones Using Polysaccharide-Based Chiral Stationary Phases.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Semi-Preparative Separation, Absolute Configuration, Stereochemical Stability and Effects on Human Neuronal Cells of MDPV Enantiomers.Molecules (Basel, Switzerland) · 2023Article
- Assessment of the Permeability of 3,4-Methylenedioxypyrovalerone (MDPV) across the Caco-2 Monolayer for Estimation of Intestinal Absorption and Enantioselectivity.International journal of molecular sciences · 2023Article
- Synthetic Cathinones: Recent Developments, Enantioselectivity Studies and Enantioseparation Methods.Molecules (Basel, Switzerland) · 2022Review
- Enantioselectivity of Pentedrone and Methylone on Metabolic Profiling in 2D and 3D Human Hepatocyte-like Cells.Pharmaceuticals (Basel, Switzerland) · 2022Article
- Strategies for Preparation of Chiral Stationary Phases: Progress on Coating and Immobilization Methods.Molecules (Basel, Switzerland) · 2021Review
- Article
- Chiral Separations in Preparative Scale: A Medicinal Chemistry Point of View.Molecules (Basel, Switzerland) · 2020Review
- Tuning Biosensor Cross-Reactivity Using Aptamer Mixtures.Analytical chemistry · 2020Article
- Abuse potential and toxicity of the synthetic cathinones (i.e., "Bath salts").Neuroscience and biobehavioral reviews · 2020Review
- Interpol review of controlled substances 2016-2019.Forensic science international. Synergy · 2020Review
- Chiral separation of cathinone derivatives using β-cyclodextrin-assisted capillary electrophoresis-Comparison of four different β-cyclodextrin derivatives used as chiral selectors.Electrophoresis · 2019Article
- Cognitive deficits and neurotoxicity induced by synthetic cathinones: is there a role for neuroinflammation?Psychopharmacology · 2019Review
- Chiral Stationary Phases for Liquid Chromatography: Recent Developments.Molecules (Basel, Switzerland) · 2019Review
- Synthetic Chiral Derivatives of Xanthones: Biological Activities and Enantioselectivity Studies.Molecules (Basel, Switzerland) · 2019Review
- Chiral determination of 3,4-methylenedioxypyrovalerone enantiomers in rat serum.Analytical methods : advancing methods and applications · 2017Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recently, great interest has been focused on synthetic cathinones since their consumption has increased exponentially. All synthetic cathinones exist as chiral molecules; the biological and/or toxicological properties of cathinones generally differ according to the enantiomers in human body. In this study, a chiral liquid chromatography method was developed to separate and determine the enantiomeric ratio of synthetic cathinones present in "legal highs" acquired in old smart shops or over the Internet. All the synthetic cathinones were efficiently enantio-separated with α and Rs ranging from 1.24 to 3.62 and from 1.24 to 10.52, respectively, using polysaccharide-based chiral stationary phases. All synthetic cathinones, with the exception of 4-methylethcathinone (4-MEC), were present in the commercialized "legal highs" in an enantiomeric proportion of 50:50. One of the studied chiral compounds was 3,4-methylenedioxypyrovalerone (MDPV), one of the most consumed cathinone derivative worldwide. Our research group has recently reported its hepatotoxicity in the racemic form. Thus, the analytical enantioresolution of the MDPV was scaled up to multi-milligram using a semi-preparative amylose
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