Evidence map›Paper›PMID 27594875›Full record

ArticleJournal of geriatric cardiology : JGC2016

Submaximal oxygen uptake kinetics, functional mobility, and physical activity in older adults with heart failure and reduced ejection fraction.

Scott L Hummel, John Herald, Craig Alpert, Kimberlee A Gretebeck, Wendy S Champoux, Donald R Dengel, Peter V Vaitkevicius, Neil B Alexander

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of geriatric cardiology : JGC, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.6field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Scott L HummelDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI, USA; VA Ann Arbor Healthcare System, Ann Arbor, MI, USA.
John HeraldDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
Craig AlpertDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
Kimberlee A GretebeckSchool of Nursing, University of Wisconsin-Madison, Madison, WI, USA.
Wendy S ChampouxWilliam Beaumont School of Medicine, Oakland University, Royal Oak, MI, USA.
Donald R DengelSchool of Kinesiology, University of Minnesota, Minneapolis, MN, USA.
Peter V VaitkeviciusAspirus Health System, Ontanagon, MI, USA.
Neil B AlexanderDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI, USA; VA Ann Arbor Healthcare System, Ann Arbor, MI, USA.
University of Michigan–Ann Arbor · USOakland University · USUniversity of Minnesota · USUniversity of Wisconsin–Madison · US

Funding

Research Education CoreP30AG024824 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Andrzej T Galecki · 2004 to 2026
$29.2M
Weight gain trajectory and life spanP60AG008808 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HALTER, JEFFREY B. · 1994 to 2003
$5.9M
Diet and pathophysiology of heart failure with preserved ejection fractionK23HL109176 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HUMMEL, SCOTT L · 2011 to 2015
$795k
NHLBI NIH HHS K23 HL109176NIA NIH HHS P30 AG024824NIA NIH HHS P60 AG008808
6 · The paper itself

Abstract

backgroundSubmaximal oxygen uptake measures are more feasible and may better predict clinical cardiac outcomes than maximal tests in older adults with heart failure (HF). We examined relationships between maximal oxygen uptake, submaximal oxygen kinetics, functional mobility, and physical activity in older adults with HF and reduced ejection fraction.

methodsOlder adults with HF and reduced ejection fraction (n = 25, age 75 ± 7 years) were compared to 25 healthy age- and gender-matched controls. Assessments included a maximal treadmill test for peak oxygen uptake (VO2peak), oxygen uptake kinetics at onset of and on recovery from a submaximal treadmill test, functional mobility testing [Get Up and Go (GUG), Comfortable Gait Speed (CGS), Unipedal Stance (US)], and self-reported physical activity (PA).

resultsCompared to controls, HF had worse performance on GUG, CGS, and US, greater delays in submaximal oxygen uptake kinetics, and lower PA. In controls, VO2peak was more strongly associated with functional mobility and PA than submaximal oxygen uptake kinetics. In HF patients, submaximal oxygen uptake kinetics were similarly associated with GUG and CGS as VO2peak, but weakly associated with PA.

conclusionsBased on their mobility performance, older HF patients with reduced ejection fraction are at risk for adverse functional outcomes. In this population, submaximal oxygen uptake measures may be equivalent to VO2 peak in predicting functional mobility, and in addition to being more feasible, may provide better insight into how aerobic function relates to mobility in older adults with HF.

Indexed as

AgingCongestive heart failureMobilityOxygen uptakeThe elderly

Identifiers

PMID27594875
PMCPMC4984569
OpenAlexW2417465906

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.