ArticleFrontiers in neuroscience2016
Pramipexole Impairs Stimulus-Response Learning in Healthy Young Adults.
Article in Frontiers in neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 25 citations in OpenAlex.
- Enhanced Taste Recognition Following Subacute Treatment With The Dopamine D2/D3 Receptor Agonist Pramipexole in Healthy Volunteers.The international journal of neuropsychopharmacology · 2022Trial
- Levodopa does not affect expression of reinforcement learning in older adults.Scientific reports · 2019Trial
- Dopamine Alters the Effect of Brain Stimulation on Decision-Making.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- NMDA receptor-related mechanisms of dopaminergic modulation of tDCS-induced neuroplasticity.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- An Experimental Medicine Investigation of the Effects of Subacute Pramipexole Treatment on Emotional Information Processing in Healthy Volunteers.Pharmaceuticals (Basel, Switzerland) · 2021Article
- Impaired Formation and Expression of Goal-Directed and Habitual Control in Parkinson's Disease.Frontiers in aging neuroscience · 2021Article
- Dopaminergic drug treatment remediates exaggerated cingulate prediction error responses in obsessive-compulsive disorder.Psychopharmacology · 2019Article
- Article
- The many facets of motor learning and their relevance for Parkinson's disease.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2017Review
- Dopaminergic Therapy Increases Go Timeouts in the Go/No-Go Task in Patients with Parkinson's Disease.Frontiers in human neuroscience · 2017Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dopaminergic therapy has paradoxical effects on cognition in Parkinson's disease (PD) patients, with some functions worsened and others improved. The dopamine overdose hypothesis is proposed as an explanation for these opposing effects of medication taking into account the varying levels of dopamine within different brain regions in PD. The detrimental effects of medication on cognition have been attributed to exogenous dopamine overdose in brain regions with spared dopamine levels in PD. It has been demonstrated that learning is most commonly worsened by dopaminergic medication. The current study aimed to investigate whether the medication-related learning impairment exhibited in PD patients is due to a main effect of medication by evaluating the dopamine overdose hypothesis in healthy young adults. Using a randomized, double-blind, placebo-controlled design, 40 healthy young undergraduate students completed a stimulus-response learning task. Half of the participants were treated with 0.5 mg of pramipexole, a dopamine agonist, whereas the other half were treated with a placebo. We found that stimulus-response learning was significantly impaired in participants on pramipexole relative to placebo controls. These findings are consistent with the dopamine overdose hypothesis and suggest that dopaminergic medication impairs learning independent of PD pathology. Our results have important clinical implications for conditions treated with pramipexole, particularly PD, restless leg syndrome, some forms of dystonia, and potentially depression.
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