ArticleBehavioural brain research2017
Altered neural connectivity in adult female rats exposed to early life social stress.
Article in Behavioural brain research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed.
- Stress During Lactation: A Hidden Link to Offspring Bone Health.Calcified tissue international · 2025Article
- Paranode length in the prefrontal cortex of subjects with major depression and rats under chronic unpredictable stress.Journal of affective disorders · 2025Article
- Somatovisceral influences on emotional development.Emotion review : journal of the International Society for Research on Emotion · 2023Article
- The impact of early-life environment on absence epilepsy and neuropsychiatric comorbidities.IBRO neuroscience reports · 2022Review
- Early life stress and neural development: Implications for understanding the developmental effects of COVID-19.Cognitive, affective & behavioral neuroscience · 2022Review
- Early Life Stress and Risks for Opioid Misuse: Review of Data Supporting Neurobiological Underpinnings.Journal of personalized medicine · 2021Review
- The Developmental Origins of Opioid Use Disorder and Its Comorbidities.Frontiers in human neuroscience · 2021Review
- Rethinking Concepts and Categories for Understanding the Neurodevelopmental Effects of Childhood Adversity.Perspectives on psychological science : a journal of the Association for Psychological Science · 2021Article
- Early life stress and development: potential mechanisms for adverse outcomes.Journal of neurodevelopmental disorders · 2020Review
- Adaptations in reward-related behaviors and mesolimbic dopamine function during motherhood and the postpartum period.Frontiers in neuroendocrinology · 2020Review
- Childhood Adversity and Affective Touch Perception: A Comparison of United Kingdom Care Leavers and Non-care Leavers.Frontiers in psychology · 2020Article
- Maternal brain resting-state connectivity in the postpartum period.Journal of neuroendocrinology · 2019Article
- The maternal reward system in postpartum depression.Archives of women's mental health · 2019Review
- Brain mechanisms mediating effects of stress on reward sensitivity.Current opinion in behavioral sciences · 2018Article
- Early life social stress and resting state functional connectivity in postpartum rat anterior cingulate circuits.Journal of affective disorders · 2018Article
- Childhood Emotional Abuse Moderates Associations Among Corticomotor White Matter Structure and Stress Neuromodulators in Women With and Without Depression.Frontiers in neuroscience · 2018Article
- Transgenerational Social Stress Alters Immune-Behavior Associations and the Response to Vaccination.Brain sciences · 2017Article
- Effects of Chronic Social Stress and Maternal Intranasal Oxytocin and Vasopressin on Offspring Interferon-γ and Behavior.Frontiers in endocrinology · 2016Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The use of a variety of neuroanatomical techniques has led to a greater understanding of the adverse effects of stress on psychiatric health. One recent advance that has been particularly valuable is the development of resting state functional connectivity (RSFC) in clinical studies. The current study investigates changes in RSFC in F1 adult female rats exposed to the early life chronic social stress (ECSS) of the daily introduction of a novel male intruder to the cage of their F0 mothers while the F1 pups are in the cage. This ECSS for the F1 animals consists of depressed maternal care from their F0 mothers and exposure to conflict between their F0 mothers and intruder males. Analyses of the functional connectivity data in ECSS exposed adult females versus control females reveal broad changes in the limbic and reward systems, the salience and introspective socioaffective networks, and several additional stress and social behavior associated nuclei. Substantial changes in connectivity were found in the prefrontal cortex, nucleus accumbens, hippocampus, and somatosensory cortex. The current rodent RSFC data support the hypothesis that the exposure to early life social stress has long term effects on neural connectivity in numerous social behavior, stress, and depression relevant brain nuclei. Future conscious rodent RSFC studies can build on the wealth of data generated from previous neuroanatomical studies of early life stress and enhance translational connectivity between animal and human fMRI studies in the development of novel preventative measures and treatments.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.