Evidence map›Paper›PMID 27594530›Full record

ArticleMagnetic resonance imaging2017

Quantifications of in vivo labeled stem cells based on measurements of magnetic moments.

Paul Kokeny, Yu-Chung N Cheng, Saifeng Liu, He Xie, Quan Jiang

Abstract read
In one paragraph

Article in Magnetic resonance imaging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Paul KokenyDepartment of Radiology, Wayne State University, Detroit, MI 48201. Electronic address: kokenymri@gmail.com.
Yu-Chung N ChengDepartment of Radiology, Wayne State University, Detroit, MI 48201. Electronic address: yxc16@wayne.edu.
Saifeng LiuThe MRI Institute for Biomedical Research, 761 Lucerne Avenue, Waterloo, ON, Canada.
He XieDepartment of Physics, Wayne State University, Detroit, MI 48201.
Quan JiangDepartment of Neurology, Henry Ford Health System, Detroit, MI 48202.

Funding

Determining properties of subvoxel objects from MRI imagesR21HL108230 · NHLBI · WAYNE STATE UNIVERSITY · PI CHENG, YU-CHUNG NORMAN · 2010 to 2011
$400k
NHLBI NIH HHS R21 HL108230
6 · The paper itself

Abstract

Cells labeled by super paramagnetic iron-oxide (SPIO) nanoparticles are more easily seen in gradient echo MR images, but it has not been shown that the amount of nanoparticles or the number of cells can be directly quantified from MR images. This work utilizes a previously developed and improved Complex Image Summation around a Spherical or Cylindrical Object (CISSCO) method to quantify the magnetic moments of several clusters of SPIO nanoparticle labeled cells from archived rat brain images. With the knowledge of mass magnetization of the cell labeling agent and cell iron uptake, the number of cells in each nanoparticle cluster can be determined. Using a high pass filter with a reasonable size has little effect on each measured magnetic moment from the CISSCO method. These procedures and quantitative results may help improve the efficacy of cell-based treatments in vivo.

Indexed as

Contrast MediaFerric CompoundsStem CellsAnimalsBrainImage EnhancementMagnetic Resonance ImagingMagneticsNanoparticlesRatsContrast MediaFerric Compoundsferric oxideMagnetic momentMRIQuantificationStem cellsSusceptibility

Identifiers

PMID27594530
PMCPMC5125907

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.