Evidence map›Paper›PMID 27594413›Full record

ArticleThe international journal of biochemistry & cell biology2016

Curcumin-loaded embryonic stem cell exosomes restored neurovascular unit following ischemia-reperfusion injury.

Anuradha Kalani, Pankaj Chaturvedi, Pradip K Kamat, Claudio Maldonado, Philip Bauer, Irving G Joshua, Suresh C Tyagi, Neetu Tyagi

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The international journal of biochemistry & cell biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 142 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
142citing papers in PubMed, 3 pooled it
8.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

142 citing papers in PubMed, 3 syntheses or guidelines pooled it, 236 citations in OpenAlex.

  1. Exosomes in pathogenesis, diagnosis, and therapy of ischemic stroke.Frontiers in bioengineering and biotechnology · 2022
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  19. Extracellular Vesicles for Disease Treatment.International journal of nanomedicine · 2025
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82 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Anuradha KalaniDepartment of Physiology, School of Medicine, University of Louisville, KY, USA. Electronic address: a0kala02@louisville.edu.
Pankaj ChaturvediDepartment of Physiology, School of Medicine, University of Louisville, KY, USA.
Pradip K KamatDepartment of Physiology, School of Medicine, University of Louisville, KY, USA.
Claudio MaldonadoDepartment of Physiology, School of Medicine, University of Louisville, KY, USA; Department of Surgery, University of Louisville, KY, USA.
Philip BauerDepartment of Surgery, University of Louisville, KY, USA.
Irving G JoshuaDepartment of Physiology, School of Medicine, University of Louisville, KY, USA.
Suresh C TyagiDepartment of Physiology, School of Medicine, University of Louisville, KY, USA.
Neetu TyagiDepartment of Physiology, School of Medicine, University of Louisville, KY, USA.
University of Louisville · US

Funding

Reversing diabetic muscle myopathy by exercise and exosomesR01HL074185 · NHLBI · UNIVERSITY OF LOUISVILLE · PI TYAGI, SURESH C. · 2003 to 2018
$5.7M
Mechanisms of Mitochondrial Dysfunction in Brain VasculatureR01HL107640 · NHLBI · UNIVERSITY OF LOUISVILLE · PI TYAGI, NEETU · 2012 to 2016
$1.8M
NHLBI NIH HHS R01 HL074185NHLBI NIH HHS R01 HL107640
6 · The paper itself

Abstract

We tested whether the combined nano-formulation, prepared with curcumin (anti-inflammatory and neuroprotective molecule) and embryonic stem cell exosomes (MESC-exo

Indexed as

AnimalsAstrocytesCell Adhesion MoleculesCurcuminDrug CompoundingEmbryonic Stem CellsEndothelial CellsExosomesGene Expression RegulationMaleMiceMice, Inbred C57BLNeuronsNeuroprotective AgentsReperfusion InjuryTight Junction ProteinsCell Adhesion MoleculesCurcuminNeuroprotective AgentsTight Junction ProteinsCurcuminExosomesNeuronsStroke

Identifiers

PMID27594413
PMCPMC5067233
OpenAlexW2510644495

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.