ArticleGenetics1989
The Caenorhabditis elegans gene sdc-2 controls sex determination and dosage compensation in XX animals.
Article in Genetics, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 88 citations in OpenAlex.
- Multilevel transcriptional regulation of embryonic sex determination and dosage compensation by the X-signal element sex-1.Genetics · 2026Article
- Condensin IDC has a functional ATPase that is required for X-Chromosome dosage compensation in C. elegans.Genetics · 2026Article
- Histone Modifications in the Cell Cycle ofEpigenomes · 2026Review
- Condensin IDC, DPY-21, and CEC-4 maintain X chromosome repression in C. elegans.PLoS genetics · 2025Article
- Multi-level transcriptional regulation of embryonic sex determination and dosage compensation by the X-signal elementbioRxiv : the preprint server for biology · 2024Article
- XOL-1 regulates developmental timing by modulating the H3K9 landscape in C. elegans early embryos.PLoS genetics · 2024Article
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- Article
- The X chromosome in C. elegans sex determination and dosage compensation.Current opinion in genetics & development · 2022Review
- Review
- X Chromosome Domain Architecture Regulates Caenorhabditis elegans Lifespan but Not Dosage Compensation.Developmental cell · 2019Article
- Barbara J. Meyer: 2018 Thomas Hunt Morgan Medal.Genetics · 2019Article
- Sex and death: from cell fate specification to dynamic control of X-chromosome structure and gene expression.Molecular biology of the cell · 2018Article
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- Article
- Chromosome-wide mechanisms to decouple gene expression from gene dose during sex-chromosome evolution.eLife · 2016Article
- Balancing up and downregulation of the C. elegans X chromosomes.Current opinion in genetics & development · 2015Review
- Linking dosage compensation and X chromosome nuclear organization in C. elegans.Nucleus (Austin, Tex.) · 2015Article
- Article
- Genome-wide analysis of condensin binding in Caenorhabditis elegans.Genome biology · 2013Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
We have identified a new X-linked gene, sdc-2, that controls the hermaphrodite (XX) modes of both sex determination and X chromosome dosage compensation in Caenorhabditis elegans. Mutations in sdc-2 cause phenotypes that appear to result from a shift of both the sex determination and dosage compensation processes in XX animals to the XO modes of expression. Twenty-eight independent sdc-2 mutations have no apparent effect in XO animals, but cause two distinct phenotypes in XX animals: masculinization, reflecting a defect in sex determination, and lethality or dumpiness, reflecting a disruption in dosage compensation. The dosage compensation defect can be demonstrated directly by showing that sdc-2 mutations cause elevated levels of several X-linked transcripts in XX but not XO animals. While the masculinization is blocked by mutations in sex determining genes required for male development (her-1 and fem-3), the lethality, dumpiness and overexpression of X-linked genes are not, indicating that the effect of sdc-2 mutations on sex determination and dosage compensation are ultimately implemented by two independent pathways. We propose a model in which sdc-2 is involved in the coordinate control of both sex determination and dosage compensation in XX animals and acts in the regulatory hierarchy at a step prior to the divergence of the two pathways.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.