Evidence map›Paper›PMID 27594172›Full record

ArticleTrends in genetics : TIG2016

A Universal Code for mRNA Stability?

Ying-Hsin Chen, Jeff Coller

Open access · greenAbstract readComment
In one paragraph

Article in Trends in genetics : TIG, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Expression Analysis of mRNA Decay of Maternal Genes duringInternational journal of molecular sciences · 2019
    Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. The Growing Toolbox for Protein Synthesis Studies.Trends in biochemical sciences · 2017
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Ying-Hsin ChenCenter for RNA Molecular Biology, Case Western Reserve University, Cleveland, OH, USA.
Jeff CollerCenter for RNA Molecular Biology, Case Western Reserve University, Cleveland, OH, USA. Electronic address: jmc71@case.edu.
Case Western Reserve University · US

Funding

Understanding the interconnection between mRNA turnover and mRNA translationR01GM080465 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI COLLER, JEFFERY · 2007 to 2016
$2.7M
NIGMS NIH HHS R01 GM080465
6 · The paper itself

Abstract

Precise elimination of maternal mRNAs plays a critical role during the maternal-to-zygotic transition (MZT) to promote developmental processing. Two new studies demonstrate that, in eukaryotes, codon-mediated decay is a conserved mechanism to shape maternal mRNA stability by affecting deadenylation rate in a translation-dependent manner. These studies add to a growing body of literature suggesting that translational elongation rates are a major determinant of mRNA stability.

Indexed as

Gene Expression Regulation, DevelopmentalProtein BiosynthesisRNA, MessengerRNA StabilityCodonEukaryotaHumansZygoteCodonRNA, Messengercodon optimalitydeadenylationmaternal-to-zygotic transitionmRNA decaytranslation

Identifiers

PMID27594172
PMCPMC5074902
OpenAlexW2515806738

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.