SynthesisYonsei medical journal2016
Prognostic Value of Extranodal Extension in Thyroid Cancer: A Meta-Analysis.
Synthesis in Yonsei medical journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The trial behind it
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Who cites it
21 citing papers in PubMed, 30 citations in OpenAlex.
- Prognostic significance of the extent of extranodal extension in patients with pN1b papillary thyroid carcinoma: a retrospective cohort study.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Article
- Moderate- versus high-activity radioactive iodine in intermediate-risk papillary thyroid cancer: a Canadian cohort study.Journal of the Endocrine Society · 2026Article
- Prognostic factors evaluated in differentiated thyroid carcinomas.Endocrine connections · 2026Review
- Ultrasound findings suggestive of microscopic extranodal extension in papillary thyroid carcinoma.Journal of medical ultrasonics (2001) · 2026Article
- Prediction of Treatment Response by Thyroid Bed Uptake on Post-Ablative Whole-Body Scan in Intermediate-Risk Patients with Papillary Thyroid Cancer.Diagnostics (Basel, Switzerland) · 2025Article
- Role of Ultrasound Elastography and Contrast-Enhanced Ultrasound (CEUS) in Diagnosis and Management of Malignant Thyroid Nodules-An Update.Diagnostics (Basel, Switzerland) · 2025Review
- Radiological extranodal extension in head and neck cancers: current evidence and challenges in imaging detection and prognostic impact.BJR open · 2025Review
- Prognostic factors of papillary and follicular carcinomas based on pre-, intra-, and post-operative findings.European thyroid journal · 2024Review
- The significance of the presence of extranodal extension in the metastatic node of differentiated thyroid cancer: a proposal for modification in the American Thyroid Association (ATA) risk stratification.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024Article
- Extranodal extension in laryngeal squamous cell carcinoma.Laryngoscope investigative otolaryngology · 2024Article
- A prediction model for identifying high-risk lymph node metastasis in clinical low-risk papillary thyroid microcarcinoma.BMC endocrine disorders · 2023Article
- Perineural Invasion in Papillary Thyroid Cancer: A Rare Indicator of Aggressive Disease.Annals of surgical oncology · 2023Article
- Data set for the reporting of pheochromocytoma and paraganglioma: explanations and recommendations of the guidelines from the International Collaboration on Cancer Reporting.Human pathology · 2021Review
- Extranodal Extension Is an Independent Prognostic Factor in Papillary Thyroid Cancer: A Propensity Score Matching Analysis.Frontiers in endocrinology · 2021Article
- Prognostic Value of Extranodal Tumor Extension in Papillary Thyroid Carcinoma: Proposal for Upstaging of Cases with Extranodal Tumor Extension.World journal of surgery · 2020Article
- Extranodal Extension as an Independent Prognostic factor in Laryngeal Squamous Cell Carcinoma Patients.Journal of Cancer · 2020Article
- Prognostic Implications of Extranodal Extension in Relation to Colorectal Cancer Location.Cancer research and treatment · 2019Article
- mRNA Expression of SLC5A5 and SLC2A Family Genes in Papillary Thyroid Cancer: An Analysis of The Cancer Genome Atlas.Yonsei medical journal · 2018Article
- Risk of recurrence in a homogeneously managed pT3-differentiated thyroid carcinoma population.Langenbeck's archives of surgery · 2018Article
- Disease-Specific Mortality of Differentiated Thyroid Cancer Patients in Korea: A Multicenter Cohort Study.Endocrinology and metabolism (Seoul, Korea) · 2017Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThyroid cancer is the most common endocrine cancer and its incidence has continuously increased in the last three decades all over the world. We aimed to evaluate the prognostic value of extranodal extension (ENE) of thyroid cancer. MATERIALS AND
methodsWe performed a systematic search of MEDLINE (from inception to June 2014) and EMBASE (from inception to June 2014) for English-language publication. The inclusion criteria were studies of thyroid cancer that reported the prognostic value of ENE in thyroid cancer. Reviews, abstracts, and editorial materials were excluded, and duplicate data were removed. Two authors performed the data extraction independently.
results6 studies including 1830 patients were eligible for inclusion in the study. All patients included in the meta-analysis had papillary thyroid cancer (PTC). Recurrence-free survival was analyzed based on 3 studies. The pooled hazard ratio for recurrence was 2.01 [95% confidence interval (CI) 1.19-3.40, p=0.009]. Disease-specific survival was analyzed based on 3 studies with 973 patients. Patients of PTC with ENE showed 3.37-fold higher risk of death from the disease (95% CI 1.55-7.32, p=0.002).
conclusionENE should be considered to be a poor prognostic marker in thyroid cancer; such knowledge might improve the management of individual patients. This might facilitate the planning of appropriate ablation therapy and tailored patient follow-up from the beginning of treatment.
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