Evidence map›Paper›PMID 27593704›Full record

ReviewReviews in medical virology2016

Lujo viral hemorrhagic fever: considering diagnostic capacity and preparedness in the wake of recent Ebola and Zika virus outbreaks.

Edgar Simulundu, Aaron S Mweene, Katendi Changula, Mwaka Monze, Elizabeth Chizema, Peter Mwaba, Ayato Takada, Guiseppe Ippolito, Francis Kasolo, Alimuddin Zumla and 1 more

Open access · greenAbstract readReview
In one paragraph

Review in Reviews in medical virology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Review
  6. Human Riboviruses: A Comprehensive Study.Journal of molecular evolution · 2025
    Review
  7. Reporter-expressing viruses for antiviral drug discovery research.Frontiers in cellular and infection microbiology · 2025
    Review
  8. Strategies of rational and structure-driven vaccine design for Arenaviruses.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2024
    Review
  9. Review
  10. Review
  11. Article
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 7 countries.

Edgar SimulunduDepartment of Disease Control, School of Veterinary Medicine, University of Zambia, Lusaka, Zambia.
Aaron S MweeneDepartment of Disease Control, School of Veterinary Medicine, University of Zambia, Lusaka, Zambia.
Katendi ChangulaDepartment of Disease Control, School of Veterinary Medicine, University of Zambia, Lusaka, Zambia.
Mwaka MonzeUniversity Teaching Hospital & National Virology Reference Laboratory, Lusaka, Zambia.
Elizabeth ChizemaMinistry of Health, Republic of Zambia.
Peter MwabaMinistry of Health, Republic of Zambia.
Ayato TakadaDepartment of Disease Control, School of Veterinary Medicine, University of Zambia, Lusaka, Zambia.
Guiseppe IppolitoLazzaro Spallanzani National Institute for Infectious Diseases, IRCCS, Rome, Italy.
Francis KasoloWorld Health Organization, WHO Africa, Brazzaville, Republic of Congo.
Alimuddin ZumlaDepartment of Infection, Division of Infection and Immunity, University College London, UK.
Matthew BatesDepartment of Infection, Division of Infection and Immunity, University College London, UK.
University of Zambia · ZMInstitute of Infection and Immunity · CAMinistry of Health · ZMIstituto Nazionale per le Malattie Infettive Lazzaro Spallanzani · ITUniversity Teaching Hospital · ZMWorld Health Organization Regional Office for Africa · CG

Funding

World Health Organization 001
6 · The paper itself

Abstract

Lujo virus is a novel Old World arenavirus identified in Southern Africa in 2008 as the cause of a viral hemorrhagic fever (VHF) characterized by nosocomial transmission with a high case fatality rate of 80% (4/5 cases). Whereas this outbreak was limited, the unprecedented Ebola virus disease outbreak in West Africa, and recent Zika virus disease epidemic in the Americas, has brought into acute focus the need for preparedness to respond to rare but potentially highly pathogenic outbreaks of zoonotic or arthropod-borne viral infections. A key determinant for effective control of a VHF outbreak is the time between primary infection and diagnosis of the index case. Here, we review the Lujo VHF outbreak of 2008 and discuss how preparatory measures with respect to developing diagnostic capacity might be effectively embedded into existing national disease control networks, such as those for human immunodeficiency virus, tuberculosis, and malaria.

Indexed as

Civil DefenseDisease OutbreaksAfrica, SouthernArenaviridae InfectionsCross InfectionDisease Transmission, InfectiousHemorrhagic Fevers, ViralHumansInfection ControlLujo virusArenaviridaediagnostic capacityEbola virus diseaselessonsLujo virusMammarenaviruspreparednessviral hemorrhagic feverZika virus

Identifiers

PMID27593704
PMCPMC7169100
OpenAlexW2519857492

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.