ArticleDiabetologia1989
Somatostatin analogue administration prevents increase in kidney somatomedin C and initial renal growth in diabetic and uninephrectomized rats.
Article in Diabetologia, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 94 citations in OpenAlex.
- Renal effects of growth hormone in health and in kidney disease.Pediatric nephrology (Berlin, Germany) · 2021Article
- Focal segmental glomerulosclerosis in which urinary protein improved after surgical treatment for acromegaly: a case report.Journal of medical case reports · 2019Article
- Effects of long-term experimental diabetes on adrenal gland growth and phosphoribosyl pyrophosphate formation in growth hormone-deficient dwarf rats.International journal of experimental pathology · 2012Article
- Effects of long-acting somatostatin analogues on adrenal growth and phosphoribosyl pyrophosphate formation in experimental diabetes.International journal of experimental pathology · 2012Article
- The glomerular podocyte as a target of growth hormone action: implications for the pathogenesis of diabetic nephropathy.Current diabetes reviews · 2011Review
- Identification of compounds that inhibit IGF-I signaling in hyperglycemia.Experimental diabetes research · 2009Article
- Autocrine and paracrine mechanisms in the early stages of diabetic nephropathy.Journal of endocrinological investigation · 1999Review
- Role of insulin-like growth factor binding proteins in human post-nephrectomy proximal tubule cells.The Journal of physiology · 1998Article
- Article
- Renal growth during pregnancy in insulin-dependent diabetic women. A prospective study of renal volume and clinical variables.Acta diabetologica · 1995Article
- The accumulation of IGF-I in kidneys of streptozotocin-diabetic adult rats is not associated with elevated plasma GH or IGF-I levels.Endocrine · 1995Article
- Effect of octreotide and insulin on manifest renal and glomerular hypertrophy and urinary albumin excretion in long-term experimental diabetes in rats.Diabetologia · 1995Article
- Effect of insulin-like growth factor I infusion on renal hypertrophy in experimental diabetes mellitus in rats.Diabetologia · 1991Article
- Renal insulin-like growth factor I and growth hormone receptor binding in experimental diabetes and after unilateral nephrectomy in the rat.Diabetologia · 1991Article
- Article
- Ultrastructural localization of IGF-I in the rat kidney; an immunocytochemical study.Histochemistry · 1990Article
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4 authors at 1 institution in 1 country.
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Abstract
In a previous study we demonstrated that the kidney content of somatomedin C was maximal one to two days after uninephrectomy or induction of diabetes, and that insulin treatment prevented an increase in kidney somatomedin C as well as kidney growth in diabetic animals. In the present study we have examined the effect of a somatostatin analogue on kidney somatomedin C and initial renal growth in the two experimental situations. The kidney hypertrophy in untreated diabetic animals amounted to 23% four days after streptozotocin injection and followed an increase in kidney somatomedin C content of 60% reaching the maximum after 48 h. In young and old uninephrectomized rats kidney growth was 19% and 16% after four days. In young animals a prompt increase of 50% in kidney somatomedin C was seen as reaching the maximum after 24 h, while the somatomedin C content in kidneys from old animals was maximal after 48 h (increase of 58%) in good accordance with the slightly slower kidney growth. The new findings of the present study are that administration of a long-acting somatostatin analogue (Sandostatin) effectively prevented the obligatory increase in kidney somatomedin C content as well as kidney growth both in experimental diabetes and after uninephrectomy. It is noteworthy that Sandostatin administration did not alter the metabolic state in diabetic animals indicating that the inhibition of kidney hypertrophy could not be attributed to improved metabolic control. The results thus support the concept that somatomedin C is involved in initial diabetic and post-nephrectomy renal growth.
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