ArticleHPB : the official journal of the International Hepato Pancreato Biliary Association2016
Measurement of liver function using hepatobiliary scintigraphy improves risk assessment in patients undergoing major liver resection.
Article in HPB : the official journal of the International Hepato Pancreato Biliary Association, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04692259 (Is It Possible To Predict PHLF? - Retrospective Analysis of Gadoxetate MRI Prior To Major Liver Resection), which is not on this map. Cited by 47 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Is It Possible To Predict PHLF? - Retrospective Analysis of Gadoxetate MRI Prior To Major Liver Resection
Who cites it
47 citing papers in PubMed, 2 syntheses or guidelines pooled it, 105 citations in OpenAlex.
- Dynamic SPECT Assessment of Hepatic Function in Patients With Liver Disease: A Systematic Review and Meta-Analysis.Journal of medical imaging and radiation oncology · 2026Pooled it
- Hepatic function assessment to predict post-hepatectomy liver failure: what can we trust? A systematic review.Updates in surgery · 2020Pooled it
- Sarcopenia does not affect total liver function measured using technetium-99m mebrofenin hepatobiliary scintigraphy.EJNMMI research · 2026Article
- Establishing the Minimum Future Liver Remnant Volume for Safe Hepatectomy.Journal of the American College of Surgeons · 2026Article
- Article
- Is There a Role for Hepatobiliary Scintigraphy in Thermal Ablation of Hepatocellular Carcinoma?Cancers · 2026Article
- Review
- Interobserver variability in the preoperative assessment of future liver remnant function using hepatobiliary scintigraphy.EJNMMI research · 2025Article
- Preoperative imaging of colorectal liver metastases: what the radiologist and the multidisciplinary team need to know.The British journal of radiology · 2024Review
- Review
- Effect of Sarcopenia on the Increase in Liver Volume and Function After Portal Vein Embolization.Cardiovascular and interventional radiology · 2024Article
- Single-Center Retrospective Study Comparing Double Vein Embolization via a Trans-Jugular Approach with Liver Venous Deprivation via a Trans-Hepatic Approach.Cardiovascular and interventional radiology · 2023Article
- Assessment of liver function before major hepatectomy.The British journal of surgery · 2023Article
- Article
- How Much Is Enough? A Surgical Perspective on Imaging Modalities to Estimate Function and Volume of the Future Liver Remnant before Hepatic Resection.Diagnostics (Basel, Switzerland) · 2023Review
- [Metastatic colorectal cancer-Modern treatment strategies and sequences].Innere Medizin (Heidelberg, Germany) · 2023Article
- Assessing Liver Fibrosis Using 2D-SWE Liver Ultrasound Elastography and Dynamic Liver Scintigraphy with 99mTc-mebrofenin: A Comparative Prospective Single-Center Study.Medicina (Kaunas, Lithuania) · 2023Article
- Functional assessment of liver regeneration after major hepatectomy.Hepatobiliary surgery and nutrition · 2022Article
- Chemico-Pharmacological Screening of the Methanol Extract ofMolecules (Basel, Switzerland) · 2022Article
- Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background(99m)Tc-mebrofenin-hepatobiliary-scintigraphy (HBS) enables measurement of future remnant liver (FRL)-function and was implemented in our preoperative routine after calculation of the cut-off value for prediction of postoperative liver failure (LF). This study evaluates our results since the implementation of HBS. Additionally, CT-volumetric methods of FRL-assessment, standardized liver volumetry and FRL/body-weight ratio (FRL-BWR), were evaluated.
methods163 patients who underwent major liver resection were included. Insufficient FRL-volume and/or FRL-function <2.7%/min/m(2) were indications for portal vein embolization (PVE). Non-PVE patients were compared with a historical cohort (n = 55). Primary endpoints were postoperative LF and LF related mortality. Secondary endpoint was preoperative identification of patients at risk for LF using the CT-volumetric methods.
results29/163 patients underwent PVE; 8/29 patients because of insufficient FRL-function despite sufficient FRL-volume. According to FRL-BWR and standardized liver volumetry, 16/29 and 11/29 patients, respectively, would not have undergone PVE. LF and LF related mortality were significantly reduced compared to the historical cohort. HBS appeared superior in the identification of patients with increased surgical risk compared to the CT-volumetric methods. DISCUSSION: Implementation of HBS in the preoperative work-up led to a function oriented use of PVE and was associated with a significant decrease in postoperative LF and LF related mortality.
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