Evidence map›Paper›PMID 27593513›Full record

ArticleCell host & microbe2016

Mammalian Innate Immune Response to a Leishmania-Resident RNA Virus Increases Macrophage Survival to Promote Parasite Persistence.

Remzi Onur Eren, Marta Reverte, Matteo Rossi, Mary-Anne Hartley, Patrik Castiglioni, Florence Prevel, Ricardo Martin, Chantal Desponds, Lon-Fye Lye, Stefan K Drexler and 4 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell host & microbe, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 78 citations in OpenAlex.

  1. Article
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  7. The Expanding Mycovirome ofJournal of fungi (Basel, Switzerland) · 2024
    Review
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  13. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Remzi Onur ErenDepartment of Biochemistry, University of Lausanne, 1066 Epalinges, Switzerland.
Marta ReverteDepartment of Biochemistry, University of Lausanne, 1066 Epalinges, Switzerland.
Matteo RossiDepartment of Biochemistry, University of Lausanne, 1066 Epalinges, Switzerland.
Mary-Anne HartleyDepartment of Biochemistry, University of Lausanne, 1066 Epalinges, Switzerland.
Patrik CastiglioniDepartment of Biochemistry, University of Lausanne, 1066 Epalinges, Switzerland.
Florence PrevelDepartment of Biochemistry, University of Lausanne, 1066 Epalinges, Switzerland.
Ricardo MartinDepartment of Biochemistry, University of Lausanne, 1066 Epalinges, Switzerland.
Chantal DespondsDepartment of Biochemistry, University of Lausanne, 1066 Epalinges, Switzerland.
Lon-Fye LyeDepartment of Molecular Microbiology, School of Medicine, Washington University, St. Louis, MO 63110, USA.
Stefan K DrexlerDepartment of Biochemistry, University of Lausanne, 1066 Epalinges, Switzerland.
Walter ReithDepartment of Pathology and Immunology, University of Geneva, 1211 Geneva, Switzerland.
Stephen M BeverleyDepartment of Molecular Microbiology, School of Medicine, Washington University, St. Louis, MO 63110, USA.
Catherine RonetDepartment of Biochemistry, University of Lausanne, 1066 Epalinges, Switzerland.
Nicolas FaselDepartment of Biochemistry, University of Lausanne, 1066 Epalinges, Switzerland. Electronic address: nicolas.fasel@unil.ch.
University of Lausanne · CHWashington University in St. Louis · USUniversity of Geneva · CH

Funding

MOLECULAR GENETICS OF LEISHMANIA USING DNA TRANSFECTIONR01AI029646 · NIAID · WASHINGTON UNIVERSITY · PI BEVERLEY, STEPHEN M · 1990 to 2015
$9.3M
Leishmania RNA virus (LRV) infectivity and host responsesR56AI099364 · NIAID · WASHINGTON UNIVERSITY · PI BEVERLEY, STEPHEN M · 2013 to 2013
$493k
NIAID NIH HHS R01 AI029646NIAID NIH HHS R56 AI099364
6 · The paper itself

Abstract

Some strains of the protozoan parasite Leishmania guyanensis (L.g) harbor a viral endosymbiont called Leishmania RNA virus 1 (LRV1). LRV1 recognition by TLR-3 increases parasite burden and lesion swelling in vivo. However, the mechanisms by which anti-viral innate immune responses affect parasitic infection are largely unknown. Upon investigating the mammalian host's response to LRV1, we found that miR-155 was singularly and strongly upregulated in macrophages infected with LRV1+ L.g when compared to LRV1- L.g. LRV1-driven miR-155 expression was dependent on TLR-3/TRIF signaling. Furthermore, LRV1-induced TLR-3 activation promoted parasite persistence by enhancing macrophage survival through Akt activation in a manner partially dependent on miR-155. Pharmacological inhibition of Akt resulted in a decrease in LRV1-mediated macrophage survival and consequently decreased parasite persistence. Consistent with these data, miR-155-deficient mice showed a drastic decrease in LRV1-induced disease severity, and lesional macrophages from these mice displayed reduced levels of Akt phosphorylation.

Indexed as

Immunity, InnateAnimalsCell SurvivalDisease Models, AnimalLeishmania guyanensisLeishmaniasis, MucocutaneousLeishmaniavirusMacrophagesMiceMice, KnockoutMicroRNAsProto-Oncogene Proteins c-aktToll-Like Receptor 3MicroRNAsMirn155 microRNA, mouseProto-Oncogene Proteins c-aktTLR3 protein, mouseToll-Like Receptor 3AktLeishmaniaLeishmania RNA virusmacrophage survivalmiR-155TLR-3

Identifiers

PMID27593513
PMCPMC5493041
OpenAlexW2512646584

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.